| Summary: | Globally, candidemia displays geographical variety in terms of epidemiology and incidence. In that respect, a nationwide Greek study was conducted, reporting the epidemiology of <i>Candida</i> bloodstream infections and susceptibility of isolates to antifungal agents providing evidence for empirical treatment. All microbiologically confirmed candidemia cases in patients hospitalized in 28 Greek centres during the period 2009–2018 were recorded. The study evaluated the incidence of infection/100,000 inhabitants, species distribution, and antifungal susceptibilities of isolated strains. Overall, 6057 candidemic episodes occurred during the study period, with 3% of them being mixed candidemias. The average annual incidence was 5.56/100,000 inhabitants, with significant increase over the years (<i>p</i> = 0.0002). <i>C. parapsilosis</i> species complex (SC) was the predominant causative agent (41%), followed by <i>C. albicans</i> (37%), <i>C. glabrata</i> SC (10%), <i>C. tropicalis</i> (7%), <i>C. krusei</i> (1%), and other rare <i>Candida</i> spp. (4%). <i>C. albicans</i> rates decreased from 2009 to 2018 (48% to 31%) in parallel with a doubling incidence of <i>C. parapsilosis</i> SC rates (28% to 49%, <i>p</i> < 0.0001). Resistance to amphotericin B and flucytosine was not observed. Resistance to fluconazole was detected in 20% of <i>C. parapsilosis</i> SC isolates, with a 4% of them being pan-azole-resistant. A considerable rising rate of resistance to this agent was observed over the study period (<i>p</i> < 0.0001). Echinocandin resistance was found in 3% of <i>C. glabrata</i> SC isolates, with 70% of them being pan-echinocandin-resistant. Resistance rate to this agent was stable over the study period. This is the first multicentre nationwide study demonstrating an increasing incidence of candidemia in Greece with a species shift toward <i>C. parapsilosis</i> SC. Although the overall antifungal resistance rates remain relatively low, fluconazole-resistant <i>C. parapsilosis</i> SC raises concern.
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