18F-FDG-PET correlates of aging and disease course in ALS as revealed by distinct PVC approaches
Purpose: The partial volume effect (PVE) complicates PET studies of neurodegenerative diseases, since a decreased 18F-FDG retention might be influenced by atrophy-related changes of cortical regions. Multiple partial volume correction (PVC) methods have been therefore developed, but their applicatio...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-01-01
|
| Series: | European Journal of Radiology Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352047722000016 |
| _version_ | 1811178921885958144 |
|---|---|
| author | Pilar M. Ferraro Cristina Campi Alberto Miceli Claudia Rolla-Bigliani Matteo Bauckneht Lorenzo Gualco Michele Piana Cecilia Marini Lucio Castellan Silvia Morbelli Claudia Caponnetto Gianmario Sambuceti Luca Roccatagliata |
| author_facet | Pilar M. Ferraro Cristina Campi Alberto Miceli Claudia Rolla-Bigliani Matteo Bauckneht Lorenzo Gualco Michele Piana Cecilia Marini Lucio Castellan Silvia Morbelli Claudia Caponnetto Gianmario Sambuceti Luca Roccatagliata |
| author_sort | Pilar M. Ferraro |
| collection | DOAJ |
| description | Purpose: The partial volume effect (PVE) complicates PET studies of neurodegenerative diseases, since a decreased 18F-FDG retention might be influenced by atrophy-related changes of cortical regions. Multiple partial volume correction (PVC) methods have been therefore developed, but their application in amyotrophic lateral sclerosis (ALS) is still rare. Additionally, even if metabolic changes have been established in ALS, no study yet has investigated how these may be influenced by aging and disease course. The aim of the present study was therefore to apply and compare multiple PVC approaches to explore aging and disease course-related hypometabolism in ALS. Methods: PET and MRI data from 15 ALS patients were analyzed using PETSurfer to implement 4 distinct PVC methods: noPVC, Meltzer (MZ), Müller-Gärtner (MG) and Symmetric Geometric Transfer Matrix (SGTM). For each method and Region of Interest (ROI), the 18F-FDG value was regressed against subject age and disease duration. Results: MG/SGTM application almost halved the number of regions showing a significant age-related hypometabolism, while the same effect was not observed for disease course, where only the distribution of identified regions varied. Three distinct patterns emerged: regions showing a significant age/disease course-related effect across all the different methods, regions yielding significance only with MG/SGTM application, and regions maintaining significance only with noPVC/MZ application. Conclusions: Significant changes in the distribution of aging and disease course-related hypometabolism were observed when the effect of the underlying structural status was considered, supporting the need for investigate the impact of PVE on PET-assessed metabolic changes in clinical and research settings. |
| first_indexed | 2024-04-11T06:26:09Z |
| format | Article |
| id | doaj.art-457e35393b374a00b12333744901d21e |
| institution | Directory Open Access Journal |
| issn | 2352-0477 |
| language | English |
| last_indexed | 2024-04-11T06:26:09Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Radiology Open |
| spelling | doaj.art-457e35393b374a00b12333744901d21e2022-12-22T04:40:21ZengElsevierEuropean Journal of Radiology Open2352-04772022-01-01910039418F-FDG-PET correlates of aging and disease course in ALS as revealed by distinct PVC approachesPilar M. Ferraro0Cristina Campi1Alberto Miceli2Claudia Rolla-Bigliani3Matteo Bauckneht4Lorenzo Gualco5Michele Piana6Cecilia Marini7Lucio Castellan8Silvia Morbelli9Claudia Caponnetto10Gianmario Sambuceti11Luca Roccatagliata12Department of Neuroradiology, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, Italy; Corresponding author.LISCOMPlab, Department of Mathematics (DIMA), University of Genoa, Via Balbi 5, 16126 Genoa, ItalyNuclear Medicine Unit, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, Italy; Department of Health Sciences (DISSAL), University of Genoa, Via Balbi 5, 16126 Genoa, ItalyDepartment of Neuroradiology, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, ItalyNuclear Medicine Unit, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, ItalyDepartment of Neuroradiology, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, Italy; Department of Health Sciences (DISSAL), University of Genoa, Via Balbi 5, 16126 Genoa, ItalyLISCOMPlab, Department of Mathematics (DIMA), University of Genoa, Via Balbi 5, 16126 Genoa, Italy; CNR Superconducting and Other Innovative materials and Devices Institute (SPIN), Corso Ferdinando Maria Perrone 24, 16152 Genoa, ItalyNuclear Medicine Unit, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, Italy; CNR Institute of Molecular Bioimaging and Physiology (IBFM), Via Fratelli Cervi 93, 20054 Segrate, ItalyDepartment of Neuroradiology, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, ItalyNuclear Medicine Unit, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, Italy; Department of Health Sciences (DISSAL), University of Genoa, Via Balbi 5, 16126 Genoa, ItalyDepartment of Neurology, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, ItalyNuclear Medicine Unit, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, Italy; Department of Health Sciences (DISSAL), University of Genoa, Via Balbi 5, 16126 Genoa, ItalyDepartment of Neuroradiology, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, Italy; Department of Health Sciences (DISSAL), University of Genoa, Via Balbi 5, 16126 Genoa, ItalyPurpose: The partial volume effect (PVE) complicates PET studies of neurodegenerative diseases, since a decreased 18F-FDG retention might be influenced by atrophy-related changes of cortical regions. Multiple partial volume correction (PVC) methods have been therefore developed, but their application in amyotrophic lateral sclerosis (ALS) is still rare. Additionally, even if metabolic changes have been established in ALS, no study yet has investigated how these may be influenced by aging and disease course. The aim of the present study was therefore to apply and compare multiple PVC approaches to explore aging and disease course-related hypometabolism in ALS. Methods: PET and MRI data from 15 ALS patients were analyzed using PETSurfer to implement 4 distinct PVC methods: noPVC, Meltzer (MZ), Müller-Gärtner (MG) and Symmetric Geometric Transfer Matrix (SGTM). For each method and Region of Interest (ROI), the 18F-FDG value was regressed against subject age and disease duration. Results: MG/SGTM application almost halved the number of regions showing a significant age-related hypometabolism, while the same effect was not observed for disease course, where only the distribution of identified regions varied. Three distinct patterns emerged: regions showing a significant age/disease course-related effect across all the different methods, regions yielding significance only with MG/SGTM application, and regions maintaining significance only with noPVC/MZ application. Conclusions: Significant changes in the distribution of aging and disease course-related hypometabolism were observed when the effect of the underlying structural status was considered, supporting the need for investigate the impact of PVE on PET-assessed metabolic changes in clinical and research settings.http://www.sciencedirect.com/science/article/pii/S235204772200001618F-FDG positron emission tomographyMagnetic resonance imagingPartial volume correctionAmyotrophic lateral sclerosis |
| spellingShingle | Pilar M. Ferraro Cristina Campi Alberto Miceli Claudia Rolla-Bigliani Matteo Bauckneht Lorenzo Gualco Michele Piana Cecilia Marini Lucio Castellan Silvia Morbelli Claudia Caponnetto Gianmario Sambuceti Luca Roccatagliata 18F-FDG-PET correlates of aging and disease course in ALS as revealed by distinct PVC approaches European Journal of Radiology Open 18F-FDG positron emission tomography Magnetic resonance imaging Partial volume correction Amyotrophic lateral sclerosis |
| title | 18F-FDG-PET correlates of aging and disease course in ALS as revealed by distinct PVC approaches |
| title_full | 18F-FDG-PET correlates of aging and disease course in ALS as revealed by distinct PVC approaches |
| title_fullStr | 18F-FDG-PET correlates of aging and disease course in ALS as revealed by distinct PVC approaches |
| title_full_unstemmed | 18F-FDG-PET correlates of aging and disease course in ALS as revealed by distinct PVC approaches |
| title_short | 18F-FDG-PET correlates of aging and disease course in ALS as revealed by distinct PVC approaches |
| title_sort | 18f fdg pet correlates of aging and disease course in als as revealed by distinct pvc approaches |
| topic | 18F-FDG positron emission tomography Magnetic resonance imaging Partial volume correction Amyotrophic lateral sclerosis |
| url | http://www.sciencedirect.com/science/article/pii/S2352047722000016 |
| work_keys_str_mv | AT pilarmferraro 18ffdgpetcorrelatesofaginganddiseasecourseinalsasrevealedbydistinctpvcapproaches AT cristinacampi 18ffdgpetcorrelatesofaginganddiseasecourseinalsasrevealedbydistinctpvcapproaches AT albertomiceli 18ffdgpetcorrelatesofaginganddiseasecourseinalsasrevealedbydistinctpvcapproaches AT claudiarollabigliani 18ffdgpetcorrelatesofaginganddiseasecourseinalsasrevealedbydistinctpvcapproaches AT matteobauckneht 18ffdgpetcorrelatesofaginganddiseasecourseinalsasrevealedbydistinctpvcapproaches AT lorenzogualco 18ffdgpetcorrelatesofaginganddiseasecourseinalsasrevealedbydistinctpvcapproaches AT michelepiana 18ffdgpetcorrelatesofaginganddiseasecourseinalsasrevealedbydistinctpvcapproaches AT ceciliamarini 18ffdgpetcorrelatesofaginganddiseasecourseinalsasrevealedbydistinctpvcapproaches AT luciocastellan 18ffdgpetcorrelatesofaginganddiseasecourseinalsasrevealedbydistinctpvcapproaches AT silviamorbelli 18ffdgpetcorrelatesofaginganddiseasecourseinalsasrevealedbydistinctpvcapproaches AT claudiacaponnetto 18ffdgpetcorrelatesofaginganddiseasecourseinalsasrevealedbydistinctpvcapproaches AT gianmariosambuceti 18ffdgpetcorrelatesofaginganddiseasecourseinalsasrevealedbydistinctpvcapproaches AT lucaroccatagliata 18ffdgpetcorrelatesofaginganddiseasecourseinalsasrevealedbydistinctpvcapproaches |