Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching treatment-resistant patients
Even though obsessive compulsive disorder (OCD) is one of the ten most disabling diseases according to the WHO, only 30–40% of patients suffering from OCD seek specialized treatment. The currently available psychotherapeutic and pharmacological approaches, when properly applied, prove ineffective in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1065812/full |
| _version_ | 1797905183065243648 |
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| author | Kevin Swierkosz-Lenart Joao Flores Alves Dos Santos Julien Elowe Julien Elowe Anne-Hélène Clair Julien F. Bally Françoise Riquier Jocelyne Bloch Bogdan Draganski Bogdan Draganski Marie-Thérèse Clerc Beatriz Pozuelo Moyano Armin von Gunten Luc Mallet Luc Mallet Luc Mallet |
| author_facet | Kevin Swierkosz-Lenart Joao Flores Alves Dos Santos Julien Elowe Julien Elowe Anne-Hélène Clair Julien F. Bally Françoise Riquier Jocelyne Bloch Bogdan Draganski Bogdan Draganski Marie-Thérèse Clerc Beatriz Pozuelo Moyano Armin von Gunten Luc Mallet Luc Mallet Luc Mallet |
| author_sort | Kevin Swierkosz-Lenart |
| collection | DOAJ |
| description | Even though obsessive compulsive disorder (OCD) is one of the ten most disabling diseases according to the WHO, only 30–40% of patients suffering from OCD seek specialized treatment. The currently available psychotherapeutic and pharmacological approaches, when properly applied, prove ineffective in about 10% of cases. The use of neuromodulation techniques, especially Deep Brain Stimulation, is highly promising for these clinical pictures and knowledge in this domain is constantly evolving. The aim of this paper is to provide a summary of the current knowledge about OCD treatment, while also discussing the more recent proposals for defining resistance. |
| first_indexed | 2024-04-10T10:01:01Z |
| format | Article |
| id | doaj.art-457fbcbd2596406a8c517c25aa61685a |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-10T10:01:01Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-457fbcbd2596406a8c517c25aa61685a2023-02-16T07:58:41ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-02-011410.3389/fpsyt.2023.10658121065812Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching treatment-resistant patientsKevin Swierkosz-Lenart0Joao Flores Alves Dos Santos1Julien Elowe2Julien Elowe3Anne-Hélène Clair4Julien F. Bally5Françoise Riquier6Jocelyne Bloch7Bogdan Draganski8Bogdan Draganski9Marie-Thérèse Clerc10Beatriz Pozuelo Moyano11Armin von Gunten12Luc Mallet13Luc Mallet14Luc Mallet15Department of Psychiatry, Service Universitaire de Psychiatrie de l’Age Avancé (SUPAA), Centre Hospitalier Universitaire Vaudois, Prilly, SwitzerlandDepartment of Mental Health and Psychiatry, Geneva University Hospital, Geneva, SwitzerlandDepartment of Psychiatry, Lausanne University Hospital, University of Lausanne, West Sector, Prangins, SwitzerlandDepartment of Psychiatry, Lausanne University Hospital, University of Lausanne, North Sector, Yverdon-les-Bains, SwitzerlandSorbonne University, UPMC Paris 06 University, INSERM, CNRS, Institut du Cerveau et de la Moelle Épinière, Paris, FranceDepartment of Clinical Neurosciences, Service of Neurology, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandDepartment of Clinical Neuroscience, Service of Neurosurgery, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, SwitzerlandDepartment of Clinical Neuroscience, Service of Neurosurgery, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, SwitzerlandLaboratory for Research in Neuroimaging (LREN), Department of Clinical Neurosciences, Centre for Research in Neurosciences, Lausanne University Hospital, University of Lausanne, Lausanne, SwitzerlandDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyDepartment of Psychiatry, Service Universitaire de Psychiatrie de l’Age Avancé (SUPAA), Centre Hospitalier Universitaire Vaudois, Prilly, SwitzerlandDepartment of Psychiatry, Service Universitaire de Psychiatrie de l’Age Avancé (SUPAA), Centre Hospitalier Universitaire Vaudois, Prilly, SwitzerlandDepartment of Psychiatry, Service Universitaire de Psychiatrie de l’Age Avancé (SUPAA), Centre Hospitalier Universitaire Vaudois, Prilly, SwitzerlandDepartment of Mental Health and Psychiatry, Geneva University Hospital, Geneva, Switzerland0Univ Paris-Est Créteil, DMU IMPACT, Département Médical-Universitaire de Psychiatrie et d’Addictologie, Hôpitaux Universitaires Henri Mondor - Albert Chenevier, Assistance Publique-Hôpitaux de Paris, Créteil, France1Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Paris, FranceEven though obsessive compulsive disorder (OCD) is one of the ten most disabling diseases according to the WHO, only 30–40% of patients suffering from OCD seek specialized treatment. The currently available psychotherapeutic and pharmacological approaches, when properly applied, prove ineffective in about 10% of cases. The use of neuromodulation techniques, especially Deep Brain Stimulation, is highly promising for these clinical pictures and knowledge in this domain is constantly evolving. The aim of this paper is to provide a summary of the current knowledge about OCD treatment, while also discussing the more recent proposals for defining resistance.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1065812/fullobsessive-compulsive disorderdeep brain stimulationneuromodulationresistantrefractory |
| spellingShingle | Kevin Swierkosz-Lenart Joao Flores Alves Dos Santos Julien Elowe Julien Elowe Anne-Hélène Clair Julien F. Bally Françoise Riquier Jocelyne Bloch Bogdan Draganski Bogdan Draganski Marie-Thérèse Clerc Beatriz Pozuelo Moyano Armin von Gunten Luc Mallet Luc Mallet Luc Mallet Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching treatment-resistant patients Frontiers in Psychiatry obsessive-compulsive disorder deep brain stimulation neuromodulation resistant refractory |
| title | Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching treatment-resistant patients |
| title_full | Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching treatment-resistant patients |
| title_fullStr | Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching treatment-resistant patients |
| title_full_unstemmed | Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching treatment-resistant patients |
| title_short | Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching treatment-resistant patients |
| title_sort | therapies for obsessive compulsive disorder current state of the art and perspectives for approaching treatment resistant patients |
| topic | obsessive-compulsive disorder deep brain stimulation neuromodulation resistant refractory |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1065812/full |
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