Selective sensitization of C-fiber nociceptors by hydrogen sulfide

Selective sensitization of C-fiber nociceptors by hydrogen sulfide

We examined the effects of intraplantar (i.pl.) administration of NaHS, an H2S donor, known to cause T-type Ca2+ channel (T-channel)-dependent mechanical hyperalgesia, on responsiveness to electric stimulation with 5, 250 and 2000 Hz sine waves (SW) that selectively excites C, Aδ and Aβ fibers, resp...

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Bibliographic Details
Main Authors: Yuka Aoki, Maho Tsubota, Yuta Nishimoto, Yumi Maeda, Fumiko Sekiguchi, Atsufumi Kawabata
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Journal of Pharmacological Sciences
Subjects:
T-type calcium channel
Hydrogen sulfide
C-fiber nociceptor
Online Access:http://www.sciencedirect.com/science/article/pii/S134786131500256X
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Summary:We examined the effects of intraplantar (i.pl.) administration of NaHS, an H2S donor, known to cause T-type Ca2+ channel (T-channel)-dependent mechanical hyperalgesia, on responsiveness to electric stimulation with 5, 250 and 2000 Hz sine waves (SW) that selectively excites C, Aδ and Aβ fibers, respectively. NaHS, given i.pl., caused behavioral hypersensitivity to SW stimulation at 5 Hz, but not 250 or 2000 Hz, in rats. NaHS also enhanced phosphorylation of spinal ERK following 5 Hz SW stimulation. Three distinct T-channel blockers abolished the NaHS-induced behavioral hypersensitivity to 5 Hz SW stimulation. Thus, H2S selectively sensitizes C-fiber nociceptors via T-channels.
ISSN:1347-8613

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