Selective sensitization of C-fiber nociceptors by hydrogen sulfide
We examined the effects of intraplantar (i.pl.) administration of NaHS, an H2S donor, known to cause T-type Ca2+ channel (T-channel)-dependent mechanical hyperalgesia, on responsiveness to electric stimulation with 5, 250 and 2000 Hz sine waves (SW) that selectively excites C, Aδ and Aβ fibers, resp...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-01-01
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| Series: | Journal of Pharmacological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S134786131500256X |
| _version_ | 1819229183817023488 |
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| author | Yuka Aoki Maho Tsubota Yuta Nishimoto Yumi Maeda Fumiko Sekiguchi Atsufumi Kawabata |
| author_facet | Yuka Aoki Maho Tsubota Yuta Nishimoto Yumi Maeda Fumiko Sekiguchi Atsufumi Kawabata |
| author_sort | Yuka Aoki |
| collection | DOAJ |
| description | We examined the effects of intraplantar (i.pl.) administration of NaHS, an H2S donor, known to cause T-type Ca2+ channel (T-channel)-dependent mechanical hyperalgesia, on responsiveness to electric stimulation with 5, 250 and 2000 Hz sine waves (SW) that selectively excites C, Aδ and Aβ fibers, respectively. NaHS, given i.pl., caused behavioral hypersensitivity to SW stimulation at 5 Hz, but not 250 or 2000 Hz, in rats. NaHS also enhanced phosphorylation of spinal ERK following 5 Hz SW stimulation. Three distinct T-channel blockers abolished the NaHS-induced behavioral hypersensitivity to 5 Hz SW stimulation. Thus, H2S selectively sensitizes C-fiber nociceptors via T-channels. |
| first_indexed | 2024-12-23T11:09:08Z |
| format | Article |
| id | doaj.art-4583ff4cc08c4456b64e3587dc03e3f2 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-23T11:09:08Z |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-4583ff4cc08c4456b64e3587dc03e3f22022-12-21T17:49:23ZengElsevierJournal of Pharmacological Sciences1347-86132016-01-011301384110.1016/j.jphs.2015.12.009Selective sensitization of C-fiber nociceptors by hydrogen sulfideYuka AokiMaho TsubotaYuta NishimotoYumi MaedaFumiko SekiguchiAtsufumi KawabataWe examined the effects of intraplantar (i.pl.) administration of NaHS, an H2S donor, known to cause T-type Ca2+ channel (T-channel)-dependent mechanical hyperalgesia, on responsiveness to electric stimulation with 5, 250 and 2000 Hz sine waves (SW) that selectively excites C, Aδ and Aβ fibers, respectively. NaHS, given i.pl., caused behavioral hypersensitivity to SW stimulation at 5 Hz, but not 250 or 2000 Hz, in rats. NaHS also enhanced phosphorylation of spinal ERK following 5 Hz SW stimulation. Three distinct T-channel blockers abolished the NaHS-induced behavioral hypersensitivity to 5 Hz SW stimulation. Thus, H2S selectively sensitizes C-fiber nociceptors via T-channels.http://www.sciencedirect.com/science/article/pii/S134786131500256XT-type calcium channelHydrogen sulfideC-fiber nociceptor |
| spellingShingle | Yuka Aoki Maho Tsubota Yuta Nishimoto Yumi Maeda Fumiko Sekiguchi Atsufumi Kawabata Selective sensitization of C-fiber nociceptors by hydrogen sulfide Journal of Pharmacological Sciences T-type calcium channel Hydrogen sulfide C-fiber nociceptor |
| title | Selective sensitization of C-fiber nociceptors by hydrogen sulfide |
| title_full | Selective sensitization of C-fiber nociceptors by hydrogen sulfide |
| title_fullStr | Selective sensitization of C-fiber nociceptors by hydrogen sulfide |
| title_full_unstemmed | Selective sensitization of C-fiber nociceptors by hydrogen sulfide |
| title_short | Selective sensitization of C-fiber nociceptors by hydrogen sulfide |
| title_sort | selective sensitization of c fiber nociceptors by hydrogen sulfide |
| topic | T-type calcium channel Hydrogen sulfide C-fiber nociceptor |
| url | http://www.sciencedirect.com/science/article/pii/S134786131500256X |
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