Identification and follow-up of pregnant women with platelet-type human platelet antigen (HPA)-1bb alloimmunized with fetal HPA-1a
Introduction : Pregnant women negative for human platelet antigen 1 a (HPA-1a) are at risk of alloimmunization with fetal HPA-1a antigen inherited from the father, and their offspring may develop fetal and neonatal alloimmune thrombocytopenia (FNAIT). The aim of this study was to analyze the freque...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2016-11-01
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| Series: | Archives of Medical Science |
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| Online Access: | https://www.termedia.pl/Identification-and-follow-up-of-pregnant-women-with-platelet-type-human-platelet-antigen-HPA-1bb-alloimmunized-with-fetal-HPA-1a,19,28681,1,1.html |
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| author | Marzena Dębska Małgorzata Uhrynowska Katarzyna Guz Izabella Kopeć Elżbieta Lachert Agnieszka Orzińska Piotr Kretowicz Jolanta Antoniewicz-Papis Romuald Dębski Magdalena Łętowska Anne Husebekk Ewa Brojer |
| author_facet | Marzena Dębska Małgorzata Uhrynowska Katarzyna Guz Izabella Kopeć Elżbieta Lachert Agnieszka Orzińska Piotr Kretowicz Jolanta Antoniewicz-Papis Romuald Dębski Magdalena Łętowska Anne Husebekk Ewa Brojer |
| author_sort | Marzena Dębska |
| collection | DOAJ |
| description | Introduction : Pregnant women negative for human platelet antigen 1 a (HPA-1a) are at risk of alloimmunization with fetal HPA-1a antigen inherited from the father, and their offspring may develop fetal and neonatal alloimmune thrombocytopenia (FNAIT). The aim of this study was to analyze the frequency of HPA-1a alloimmunization in pregnant Polish women, the feasibility of using maternal platelets for intrauterine transfusions in women subjected to diagnostic fetal blood sampling (FBS) and to discuss potential consequences of alloimmunization.
Material and methods : Fifteen thousand two hundred and four pregnant women were typed for HPA-1a; HPA-1a negative were screened for anti-HPA-1a. Alloimmunized women received specialist perinatology care; some of them were subjected to FBS, followed by transfusion of HPA-1a negative platelet concentrates (PC) prepared from maternal blood.
Results : Three hundred seventy-three (2.5%) women were HPA-1a negative, and 32 (8.6%) tested positively for anti-HPA-1a. Antibodies were detected in 22 women during pregnancy. Diagnostic FBS followed by PC transfusion was performed in 14 woman, who were platelet donors for their 16 unborn babies. Blood donations were tolerated well by the patients, and also intrauterine platelet transfusions were uneventful. Pharmacotherapy with intravenous immunoglobulins was implemented in 11/22 patients.
Conclusions : HPA-1a negative women (ca. 2.5% of all pregnant patients) are at risk of alloimmunization with HPA-1a antigen and developing FNAIT. Alloimmunized women can be donors of platelets for their offspring providing removal of antibodies from PC. Owing to potential complications, special care should be taken if an alloimmunized woman was qualified as a blood or stem cell recipient. |
| first_indexed | 2024-04-14T02:06:43Z |
| format | Article |
| id | doaj.art-4584c56eca31439fb15b493379270a80 |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-04-14T02:06:43Z |
| publishDate | 2016-11-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-4584c56eca31439fb15b493379270a802022-12-22T02:18:37ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512016-11-011451041104710.5114/aoms.2016.6360028681Identification and follow-up of pregnant women with platelet-type human platelet antigen (HPA)-1bb alloimmunized with fetal HPA-1aMarzena DębskaMałgorzata UhrynowskaKatarzyna GuzIzabella KopećElżbieta LachertAgnieszka OrzińskaPiotr KretowiczJolanta Antoniewicz-PapisRomuald DębskiMagdalena ŁętowskaAnne HusebekkEwa BrojerIntroduction : Pregnant women negative for human platelet antigen 1 a (HPA-1a) are at risk of alloimmunization with fetal HPA-1a antigen inherited from the father, and their offspring may develop fetal and neonatal alloimmune thrombocytopenia (FNAIT). The aim of this study was to analyze the frequency of HPA-1a alloimmunization in pregnant Polish women, the feasibility of using maternal platelets for intrauterine transfusions in women subjected to diagnostic fetal blood sampling (FBS) and to discuss potential consequences of alloimmunization. Material and methods : Fifteen thousand two hundred and four pregnant women were typed for HPA-1a; HPA-1a negative were screened for anti-HPA-1a. Alloimmunized women received specialist perinatology care; some of them were subjected to FBS, followed by transfusion of HPA-1a negative platelet concentrates (PC) prepared from maternal blood. Results : Three hundred seventy-three (2.5%) women were HPA-1a negative, and 32 (8.6%) tested positively for anti-HPA-1a. Antibodies were detected in 22 women during pregnancy. Diagnostic FBS followed by PC transfusion was performed in 14 woman, who were platelet donors for their 16 unborn babies. Blood donations were tolerated well by the patients, and also intrauterine platelet transfusions were uneventful. Pharmacotherapy with intravenous immunoglobulins was implemented in 11/22 patients. Conclusions : HPA-1a negative women (ca. 2.5% of all pregnant patients) are at risk of alloimmunization with HPA-1a antigen and developing FNAIT. Alloimmunized women can be donors of platelets for their offspring providing removal of antibodies from PC. Owing to potential complications, special care should be taken if an alloimmunized woman was qualified as a blood or stem cell recipient.https://www.termedia.pl/Identification-and-follow-up-of-pregnant-women-with-platelet-type-human-platelet-antigen-HPA-1bb-alloimmunized-with-fetal-HPA-1a,19,28681,1,1.htmlHPA-1a cohort study anti-human platelet antigen 1a antibodies fetal/neonatal alloimmune thrombocytopenia platelet transfusions |
| spellingShingle | Marzena Dębska Małgorzata Uhrynowska Katarzyna Guz Izabella Kopeć Elżbieta Lachert Agnieszka Orzińska Piotr Kretowicz Jolanta Antoniewicz-Papis Romuald Dębski Magdalena Łętowska Anne Husebekk Ewa Brojer Identification and follow-up of pregnant women with platelet-type human platelet antigen (HPA)-1bb alloimmunized with fetal HPA-1a Archives of Medical Science HPA-1a cohort study anti-human platelet antigen 1a antibodies fetal/neonatal alloimmune thrombocytopenia platelet transfusions |
| title | Identification and follow-up of pregnant women with platelet-type human platelet antigen (HPA)-1bb alloimmunized with fetal HPA-1a |
| title_full | Identification and follow-up of pregnant women with platelet-type human platelet antigen (HPA)-1bb alloimmunized with fetal HPA-1a |
| title_fullStr | Identification and follow-up of pregnant women with platelet-type human platelet antigen (HPA)-1bb alloimmunized with fetal HPA-1a |
| title_full_unstemmed | Identification and follow-up of pregnant women with platelet-type human platelet antigen (HPA)-1bb alloimmunized with fetal HPA-1a |
| title_short | Identification and follow-up of pregnant women with platelet-type human platelet antigen (HPA)-1bb alloimmunized with fetal HPA-1a |
| title_sort | identification and follow up of pregnant women with platelet type human platelet antigen hpa 1bb alloimmunized with fetal hpa 1a |
| topic | HPA-1a cohort study anti-human platelet antigen 1a antibodies fetal/neonatal alloimmune thrombocytopenia platelet transfusions |
| url | https://www.termedia.pl/Identification-and-follow-up-of-pregnant-women-with-platelet-type-human-platelet-antigen-HPA-1bb-alloimmunized-with-fetal-HPA-1a,19,28681,1,1.html |
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