The Outcomes of Enamel Matrix Derivative on Periodontal Regeneration under Diabetic Conditions
<i>Background and Objectives</i>: Enamel matrix derivative (EMD) is a biomaterial used for periodontal regenerative therapy due to its properties of stimulating cementum development and bone synthesis. Diabetes is a chronic condition that affects healing and predisposes to infection. The...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/57/10/1071 |
| _version_ | 1797513957521489920 |
|---|---|
| author | Laura Elena Narita Alexandru Mester Florin Onisor Simion Bran Maria Ioana Onicas Andrada Voina-Tonea |
| author_facet | Laura Elena Narita Alexandru Mester Florin Onisor Simion Bran Maria Ioana Onicas Andrada Voina-Tonea |
| author_sort | Laura Elena Narita |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Enamel matrix derivative (EMD) is a biomaterial used for periodontal regenerative therapy due to its properties of stimulating cementum development and bone synthesis. Diabetes is a chronic condition that affects healing and predisposes to infection. The aim of this review was to evaluate the current studies available on the application and results of EMD for periodontal regenerative therapy under diabetic conditions. <i>Materials and Methods</i>: Five databases (PubMed, ResearchGate, Scopus, Web of Science and Google Scholar) were searched for relevant articles, using specific keywords in different combinations. The inclusion criteria were clinical trials, case reports, case studies, and animal studies published in English, where periodontal treatment for bone defects includes EMD, and it is performed under diabetic conditions. <i>Results</i>: Of the 310 articles resulted in search, five studies published between 2012 and 2020 met the inclusion criteria and were selected for the current review. In human studies, the use of EMD in infrabony defects showed favorable results at follow-up. In animal studies, periodontal regeneration was reduced in diabetic rats. <i>Conclusions</i>: EMD might promote bone healing when used under diabetic conditions for the regenerative periodontal therapy. Due to limited number of studies, more data are required to sustain the effects of EMD therapy in diabetic settings. |
| first_indexed | 2024-03-10T06:23:50Z |
| format | Article |
| id | doaj.art-4585330f65b849f5a78dbaf092294c3f |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T06:23:50Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-4585330f65b849f5a78dbaf092294c3f2023-11-22T19:04:26ZengMDPI AGMedicina1010-660X1648-91442021-10-015710107110.3390/medicina57101071The Outcomes of Enamel Matrix Derivative on Periodontal Regeneration under Diabetic ConditionsLaura Elena Narita0Alexandru Mester1Florin Onisor2Simion Bran3Maria Ioana Onicas4Andrada Voina-Tonea5Faculty of Dental Medicine, University of Medicine and Pharmacy „Iuliu Hatieganu”, 400012 Cluj-Napoca, RomaniaDepartment of Oral Health, University of Medicine and Pharmacy „Iuliu Hatieganu”, 400012 Cluj-Napoca, RomaniaDepartment of Maxillofacial Surgery and Implantology, University of Medicine and Pharmacy „Iuliu Hatieganu”, 400012 Cluj-Napoca, RomaniaDepartment of Maxillofacial Surgery and Implantology, University of Medicine and Pharmacy „Iuliu Hatieganu”, 400012 Cluj-Napoca, RomaniaFaculty of Dental Medicine, University of Medicine and Pharmacy „Iuliu Hatieganu”, 400012 Cluj-Napoca, RomaniaDepartment of Dental Materials, University of Medicine and Pharmacy „Iuliu Hațieganu”, 400012 Cluj-Napoca, Romania<i>Background and Objectives</i>: Enamel matrix derivative (EMD) is a biomaterial used for periodontal regenerative therapy due to its properties of stimulating cementum development and bone synthesis. Diabetes is a chronic condition that affects healing and predisposes to infection. The aim of this review was to evaluate the current studies available on the application and results of EMD for periodontal regenerative therapy under diabetic conditions. <i>Materials and Methods</i>: Five databases (PubMed, ResearchGate, Scopus, Web of Science and Google Scholar) were searched for relevant articles, using specific keywords in different combinations. The inclusion criteria were clinical trials, case reports, case studies, and animal studies published in English, where periodontal treatment for bone defects includes EMD, and it is performed under diabetic conditions. <i>Results</i>: Of the 310 articles resulted in search, five studies published between 2012 and 2020 met the inclusion criteria and were selected for the current review. In human studies, the use of EMD in infrabony defects showed favorable results at follow-up. In animal studies, periodontal regeneration was reduced in diabetic rats. <i>Conclusions</i>: EMD might promote bone healing when used under diabetic conditions for the regenerative periodontal therapy. Due to limited number of studies, more data are required to sustain the effects of EMD therapy in diabetic settings.https://www.mdpi.com/1648-9144/57/10/1071enamel matrix proteinsEMDdiabetestissue repairperiodontal regeneration |
| spellingShingle | Laura Elena Narita Alexandru Mester Florin Onisor Simion Bran Maria Ioana Onicas Andrada Voina-Tonea The Outcomes of Enamel Matrix Derivative on Periodontal Regeneration under Diabetic Conditions Medicina enamel matrix proteins EMD diabetes tissue repair periodontal regeneration |
| title | The Outcomes of Enamel Matrix Derivative on Periodontal Regeneration under Diabetic Conditions |
| title_full | The Outcomes of Enamel Matrix Derivative on Periodontal Regeneration under Diabetic Conditions |
| title_fullStr | The Outcomes of Enamel Matrix Derivative on Periodontal Regeneration under Diabetic Conditions |
| title_full_unstemmed | The Outcomes of Enamel Matrix Derivative on Periodontal Regeneration under Diabetic Conditions |
| title_short | The Outcomes of Enamel Matrix Derivative on Periodontal Regeneration under Diabetic Conditions |
| title_sort | outcomes of enamel matrix derivative on periodontal regeneration under diabetic conditions |
| topic | enamel matrix proteins EMD diabetes tissue repair periodontal regeneration |
| url | https://www.mdpi.com/1648-9144/57/10/1071 |
| work_keys_str_mv | AT lauraelenanarita theoutcomesofenamelmatrixderivativeonperiodontalregenerationunderdiabeticconditions AT alexandrumester theoutcomesofenamelmatrixderivativeonperiodontalregenerationunderdiabeticconditions AT florinonisor theoutcomesofenamelmatrixderivativeonperiodontalregenerationunderdiabeticconditions AT simionbran theoutcomesofenamelmatrixderivativeonperiodontalregenerationunderdiabeticconditions AT mariaioanaonicas theoutcomesofenamelmatrixderivativeonperiodontalregenerationunderdiabeticconditions AT andradavoinatonea theoutcomesofenamelmatrixderivativeonperiodontalregenerationunderdiabeticconditions AT lauraelenanarita outcomesofenamelmatrixderivativeonperiodontalregenerationunderdiabeticconditions AT alexandrumester outcomesofenamelmatrixderivativeonperiodontalregenerationunderdiabeticconditions AT florinonisor outcomesofenamelmatrixderivativeonperiodontalregenerationunderdiabeticconditions AT simionbran outcomesofenamelmatrixderivativeonperiodontalregenerationunderdiabeticconditions AT mariaioanaonicas outcomesofenamelmatrixderivativeonperiodontalregenerationunderdiabeticconditions AT andradavoinatonea outcomesofenamelmatrixderivativeonperiodontalregenerationunderdiabeticconditions |