Smartphone-Based Digital Biomarkers for Parkinson’s Disease in a Remotely-Administered Setting
Smartphone-based digital biomarker (DB) assessments provide objective measures of daily-life tasks and thus hold the promise to improve diagnosis and monitoring of Parkinson’s disease (PD). To date, little is known about which tasks perform best for these purposes and how different confou...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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IEEE
2022-01-01
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| Series: | IEEE Access |
| Subjects: | |
| Online Access: | https://ieeexplore.ieee.org/document/9727108/ |
| _version_ | 1829136314023280640 |
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| author | Maria Goni Simon B. Eickhoff Mehran Sahandi Far Kaustubh R. Patil Juergen Dukart |
| author_facet | Maria Goni Simon B. Eickhoff Mehran Sahandi Far Kaustubh R. Patil Juergen Dukart |
| author_sort | Maria Goni |
| collection | DOAJ |
| description | Smartphone-based digital biomarker (DB) assessments provide objective measures of daily-life tasks and thus hold the promise to improve diagnosis and monitoring of Parkinson’s disease (PD). To date, little is known about which tasks perform best for these purposes and how different confounds including comorbidities, age and sex affect their accuracy. Here we systematically assess the ability of common self-administered smartphone-based tasks to differentiate PD patients and healthy controls (HC) with and without accounting for the above confounds. Using a large cohort of PD patients and healthy volunteers acquired in the mPower study, we extracted about 700 features commonly reported in previous PD studies for gait, balance, voice and tapping tasks. We perform a series of experiments systematically assessing the effects of age, sex and comorbidities on the accuracy of the above tasks for differentiation of PD patients and HC using several machine learning algorithms. When accounting for age, sex and comorbidities, the highest balanced accuracy on hold-out data (73%) was achieved using random forest when combining all tasks followed by tapping using relevance vector machine (67%). Only moderate accuracies were achieved for other tasks (60% for balance, 56% for gait and 53% for voice data). Not accounting for the confounders consistently yielded higher accuracies of up to 77% when combining all tasks. Our results demonstrate the importance of controlling DB data for age and comorbidities. |
| first_indexed | 2024-12-14T18:40:52Z |
| format | Article |
| id | doaj.art-458792ea0e6f425797ae838acb725444 |
| institution | Directory Open Access Journal |
| issn | 2169-3536 |
| language | English |
| last_indexed | 2024-12-14T18:40:52Z |
| publishDate | 2022-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Access |
| spelling | doaj.art-458792ea0e6f425797ae838acb7254442022-12-21T22:51:30ZengIEEEIEEE Access2169-35362022-01-0110283612838410.1109/ACCESS.2022.31566599727108Smartphone-Based Digital Biomarkers for Parkinson’s Disease in a Remotely-Administered SettingMaria Goni0https://orcid.org/0000-0001-7897-2537Simon B. Eickhoff1Mehran Sahandi Far2Kaustubh R. Patil3https://orcid.org/0000-0002-0289-5480Juergen Dukart4Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Centre Jülich, Jülich, GermanyInstitute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Centre Jülich, Jülich, GermanyInstitute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Centre Jülich, Jülich, GermanyInstitute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Centre Jülich, Jülich, GermanyInstitute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Centre Jülich, Jülich, GermanySmartphone-based digital biomarker (DB) assessments provide objective measures of daily-life tasks and thus hold the promise to improve diagnosis and monitoring of Parkinson’s disease (PD). To date, little is known about which tasks perform best for these purposes and how different confounds including comorbidities, age and sex affect their accuracy. Here we systematically assess the ability of common self-administered smartphone-based tasks to differentiate PD patients and healthy controls (HC) with and without accounting for the above confounds. Using a large cohort of PD patients and healthy volunteers acquired in the mPower study, we extracted about 700 features commonly reported in previous PD studies for gait, balance, voice and tapping tasks. We perform a series of experiments systematically assessing the effects of age, sex and comorbidities on the accuracy of the above tasks for differentiation of PD patients and HC using several machine learning algorithms. When accounting for age, sex and comorbidities, the highest balanced accuracy on hold-out data (73%) was achieved using random forest when combining all tasks followed by tapping using relevance vector machine (67%). Only moderate accuracies were achieved for other tasks (60% for balance, 56% for gait and 53% for voice data). Not accounting for the confounders consistently yielded higher accuracies of up to 77% when combining all tasks. Our results demonstrate the importance of controlling DB data for age and comorbidities.https://ieeexplore.ieee.org/document/9727108/Digital biomarkersmachine learningParkinson’s diseasesmartphoneswearable devices |
| spellingShingle | Maria Goni Simon B. Eickhoff Mehran Sahandi Far Kaustubh R. Patil Juergen Dukart Smartphone-Based Digital Biomarkers for Parkinson’s Disease in a Remotely-Administered Setting IEEE Access Digital biomarkers machine learning Parkinson’s disease smartphones wearable devices |
| title | Smartphone-Based Digital Biomarkers for Parkinson’s Disease in a Remotely-Administered Setting |
| title_full | Smartphone-Based Digital Biomarkers for Parkinson’s Disease in a Remotely-Administered Setting |
| title_fullStr | Smartphone-Based Digital Biomarkers for Parkinson’s Disease in a Remotely-Administered Setting |
| title_full_unstemmed | Smartphone-Based Digital Biomarkers for Parkinson’s Disease in a Remotely-Administered Setting |
| title_short | Smartphone-Based Digital Biomarkers for Parkinson’s Disease in a Remotely-Administered Setting |
| title_sort | smartphone based digital biomarkers for parkinson x2019 s disease in a remotely administered setting |
| topic | Digital biomarkers machine learning Parkinson’s disease smartphones wearable devices |
| url | https://ieeexplore.ieee.org/document/9727108/ |
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