Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei'
We thank Keith Matthews and Stephen Larcombe for their thoughtful comment, which follows the good tradition of public scientific discourse (Matthews and Larcombe, 2022). While their remarks have prompted us to take another critical look at our data, we think that they neither alter our conclusions n...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2022-02-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/75922 |
| _version_ | 1818026446587691008 |
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| author | Jaime Lisack Brooke Morriswood Markus Engstler |
| author_facet | Jaime Lisack Brooke Morriswood Markus Engstler |
| author_sort | Jaime Lisack |
| collection | DOAJ |
| description | We thank Keith Matthews and Stephen Larcombe for their thoughtful comment, which follows the good tradition of public scientific discourse (Matthews and Larcombe, 2022). While their remarks have prompted us to take another critical look at our data, we think that they neither alter our conclusions nor offer a practical alternative explanation. In essence, we see two possible interpretations of our experiments: either the trypanosome life cycle can accommodate a more flexible role for the slender stage, or the definition of the stumpy stage needs to be radically changed. While the first interpretation – which we favour – would not falsify any published work, the second one – which Matthews and Larcombe are proposing – would contradict the literature. Hence, we favour a model with an unexpected phenotypic plasticity for the slender stage and a certain degree of stochasticity in the trypanosome life cycle. |
| first_indexed | 2024-12-10T04:32:08Z |
| format | Article |
| id | doaj.art-4588094b497a4418a9d7280d3f5aa089 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-12-10T04:32:08Z |
| publishDate | 2022-02-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-4588094b497a4418a9d7280d3f5aa0892022-12-22T02:02:07ZengeLife Sciences Publications LtdeLife2050-084X2022-02-011110.7554/eLife.75922Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei'Jaime Lisack0https://orcid.org/0000-0001-9621-4000Brooke Morriswood1https://orcid.org/0000-0001-7031-3801Markus Engstler2https://orcid.org/0000-0003-1436-5759Department of Cell and Developmental Biology, University of Würzburg, Würzburg, GermanyDepartment of Cell and Developmental Biology, University of Würzburg, Würzburg, GermanyDepartment of Cell and Developmental Biology, University of Würzburg, Würzburg, GermanyWe thank Keith Matthews and Stephen Larcombe for their thoughtful comment, which follows the good tradition of public scientific discourse (Matthews and Larcombe, 2022). While their remarks have prompted us to take another critical look at our data, we think that they neither alter our conclusions nor offer a practical alternative explanation. In essence, we see two possible interpretations of our experiments: either the trypanosome life cycle can accommodate a more flexible role for the slender stage, or the definition of the stumpy stage needs to be radically changed. While the first interpretation – which we favour – would not falsify any published work, the second one – which Matthews and Larcombe are proposing – would contradict the literature. Hence, we favour a model with an unexpected phenotypic plasticity for the slender stage and a certain degree of stochasticity in the trypanosome life cycle.https://elifesciences.org/articles/75922parasite life cycletrypanosomaTsetse fly |
| spellingShingle | Jaime Lisack Brooke Morriswood Markus Engstler Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei' eLife parasite life cycle trypanosoma Tsetse fly |
| title | Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei' |
| title_full | Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei' |
| title_fullStr | Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei' |
| title_full_unstemmed | Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei' |
| title_short | Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei' |
| title_sort | response to comment on unexpected plasticity in the life cycle of trypanosoma brucei |
| topic | parasite life cycle trypanosoma Tsetse fly |
| url | https://elifesciences.org/articles/75922 |
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