Autophagy and Autophagy-Related Diseases: A Review
Autophagy refers to the process involving the decomposition of intracellular components via lysosomes. Autophagy plays an important role in maintaining and regulating cell homeostasis by degrading intracellular components and providing degradation products to cells. In vivo, autophagy has been shown...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/23/8974 |
| _version_ | 1797546696984494080 |
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| author | Tadashi Ichimiya Tsukasa Yamakawa Takehiro Hirano Yoshihiro Yokoyama Yuki Hayashi Daisuke Hirayama Kohei Wagatsuma Takao Itoi Hiroshi Nakase |
| author_facet | Tadashi Ichimiya Tsukasa Yamakawa Takehiro Hirano Yoshihiro Yokoyama Yuki Hayashi Daisuke Hirayama Kohei Wagatsuma Takao Itoi Hiroshi Nakase |
| author_sort | Tadashi Ichimiya |
| collection | DOAJ |
| description | Autophagy refers to the process involving the decomposition of intracellular components via lysosomes. Autophagy plays an important role in maintaining and regulating cell homeostasis by degrading intracellular components and providing degradation products to cells. In vivo, autophagy has been shown to be involved in the starvation response, intracellular quality control, early development, and cell differentiation. Recent studies have revealed that autophagy dysfunction is implicated in neurodegenerative diseases and tumorigenesis. In addition to the discovery of certain disease-causing autophagy-related mutations and elucidation of the pathogenesis of conditions resulting from the abnormal degradation of selective autophagy substrates, the activation of autophagy is essential for prolonging life and suppressing aging. This article provides a comprehensive review of the role of autophagy in health, physiological function, and autophagy-related disease. |
| first_indexed | 2024-03-10T14:32:55Z |
| format | Article |
| id | doaj.art-4588b000e4824f529798ade314acd901 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:32:55Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4588b000e4824f529798ade314acd9012023-11-20T22:24:22ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-012123897410.3390/ijms21238974Autophagy and Autophagy-Related Diseases: A ReviewTadashi Ichimiya0Tsukasa Yamakawa1Takehiro Hirano2Yoshihiro Yokoyama3Yuki Hayashi4Daisuke Hirayama5Kohei Wagatsuma6Takao Itoi7Hiroshi Nakase8Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo 060-8543, JapanDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo 060-8543, JapanDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo 060-8543, JapanDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo 060-8543, JapanDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo 060-8543, JapanDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo 060-8543, JapanDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo 060-8543, JapanDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo 160-0023, JapanDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo 060-8543, JapanAutophagy refers to the process involving the decomposition of intracellular components via lysosomes. Autophagy plays an important role in maintaining and regulating cell homeostasis by degrading intracellular components and providing degradation products to cells. In vivo, autophagy has been shown to be involved in the starvation response, intracellular quality control, early development, and cell differentiation. Recent studies have revealed that autophagy dysfunction is implicated in neurodegenerative diseases and tumorigenesis. In addition to the discovery of certain disease-causing autophagy-related mutations and elucidation of the pathogenesis of conditions resulting from the abnormal degradation of selective autophagy substrates, the activation of autophagy is essential for prolonging life and suppressing aging. This article provides a comprehensive review of the role of autophagy in health, physiological function, and autophagy-related disease.https://www.mdpi.com/1422-0067/21/23/8974autophagyautophagy-related genemitophagycancerneurodegenerative diseasecardiovascular |
| spellingShingle | Tadashi Ichimiya Tsukasa Yamakawa Takehiro Hirano Yoshihiro Yokoyama Yuki Hayashi Daisuke Hirayama Kohei Wagatsuma Takao Itoi Hiroshi Nakase Autophagy and Autophagy-Related Diseases: A Review International Journal of Molecular Sciences autophagy autophagy-related gene mitophagy cancer neurodegenerative disease cardiovascular |
| title | Autophagy and Autophagy-Related Diseases: A Review |
| title_full | Autophagy and Autophagy-Related Diseases: A Review |
| title_fullStr | Autophagy and Autophagy-Related Diseases: A Review |
| title_full_unstemmed | Autophagy and Autophagy-Related Diseases: A Review |
| title_short | Autophagy and Autophagy-Related Diseases: A Review |
| title_sort | autophagy and autophagy related diseases a review |
| topic | autophagy autophagy-related gene mitophagy cancer neurodegenerative disease cardiovascular |
| url | https://www.mdpi.com/1422-0067/21/23/8974 |
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