Vitamin C-Induced Epigenetic Modifications in Donor NSCs Establish Midbrain Marker Expressions Critical for Cell-Based Therapy in Parkinson's Disease

Vitamin C-Induced Epigenetic Modifications in Donor NSCs Establish Midbrain Marker Expressions Critical for Cell-Based Therapy in Parkinson's Disease

Cultured neural stem/precursor cells (NSCs) are regarded as a potential systematic cell source to treat Parkinson's disease (PD). However, the therapeutic potential of these cultured NSCs is lost during culturing. Here, we show that treatment of vitamin C (VC) enhances generation of authentic m...

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Bibliographic Details
Main Authors: Noviana Wulansari, Eun-Hee Kim, Yanuar Alan Sulistio, Yong-Hee Rhee, Jae-Jin Song, Sang-Hun Lee
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Stem Cell Reports
Subjects:
neural stem cell
ventral midbrain
vitamin C
epigenetic
Parkinson's disease
cell transplantation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117303740

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http://www.sciencedirect.com/science/article/pii/S2213671117303740

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