Extracellular Vesicle-Dependent Communication Between Mesenchymal Stromal Cells and Immune Effector Cells
Mesenchymal stem/stromal cells (MSCs) are multipotent cells residing in the stromal tissues of the body and capable of promoting tissue repair and attenuating inflammatory processes through their immunomodulatory properties. Preclinical and clinical observations revealed that not only direct interce...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2020.596079/full |
| _version_ | 1819009656701321216 |
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| author | Riccardo Bazzoni Paul Takam Kamga Paul Takam Kamga Ilaria Tanasi Mauro Krampera |
| author_facet | Riccardo Bazzoni Paul Takam Kamga Paul Takam Kamga Ilaria Tanasi Mauro Krampera |
| author_sort | Riccardo Bazzoni |
| collection | DOAJ |
| description | Mesenchymal stem/stromal cells (MSCs) are multipotent cells residing in the stromal tissues of the body and capable of promoting tissue repair and attenuating inflammatory processes through their immunomodulatory properties. Preclinical and clinical observations revealed that not only direct intercellular communication mediates MSC properties; in fact, a pivotal role is also played by the release of soluble and bioactive factors, such as cytokines, growth factor and extracellular vesicles (EVs). EVs are membrane-coated vesicles containing a large variety of bioactive molecules, including lipids, proteins, and nucleic acids, such as RNA. EVs release their contents into target cells, thus influencing cell fate through the control of intracellular processes. In addition, MSC-derived EVs can mediate modulatory effects toward different effector cells belonging to both innate and adaptive immunity. In this review, we will discuss the literature data concerning MSC-derived EVs, including the current standardized methods for their isolation and characterization, the mechanisms supporting their immunoregulatory properties, and their potential clinical application as alternative to MSC-based therapy for inflammatory reactions, such as graft-versus-host disease (GvHD). |
| first_indexed | 2024-12-21T00:59:50Z |
| format | Article |
| id | doaj.art-458b1039b57f49799613609e94fda1b3 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-21T00:59:50Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-458b1039b57f49799613609e94fda1b32022-12-21T19:21:13ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-11-01810.3389/fcell.2020.596079596079Extracellular Vesicle-Dependent Communication Between Mesenchymal Stromal Cells and Immune Effector CellsRiccardo Bazzoni0Paul Takam Kamga1Paul Takam Kamga2Ilaria Tanasi3Mauro Krampera4Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, ItalyStem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, ItalyEA4340-BCOH, Biomarker in Cancerology and Onco-Haematology, UVSQ, Université Paris Saclay, Boulogne-Billancourt, FranceStem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, ItalyStem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, ItalyMesenchymal stem/stromal cells (MSCs) are multipotent cells residing in the stromal tissues of the body and capable of promoting tissue repair and attenuating inflammatory processes through their immunomodulatory properties. Preclinical and clinical observations revealed that not only direct intercellular communication mediates MSC properties; in fact, a pivotal role is also played by the release of soluble and bioactive factors, such as cytokines, growth factor and extracellular vesicles (EVs). EVs are membrane-coated vesicles containing a large variety of bioactive molecules, including lipids, proteins, and nucleic acids, such as RNA. EVs release their contents into target cells, thus influencing cell fate through the control of intracellular processes. In addition, MSC-derived EVs can mediate modulatory effects toward different effector cells belonging to both innate and adaptive immunity. In this review, we will discuss the literature data concerning MSC-derived EVs, including the current standardized methods for their isolation and characterization, the mechanisms supporting their immunoregulatory properties, and their potential clinical application as alternative to MSC-based therapy for inflammatory reactions, such as graft-versus-host disease (GvHD).https://www.frontiersin.org/articles/10.3389/fcell.2020.596079/fullextracellular vesiclesexosomesmicrovesiclesmesenchymal stromal cellsimmune effector cellsimmunomodulation |
| spellingShingle | Riccardo Bazzoni Paul Takam Kamga Paul Takam Kamga Ilaria Tanasi Mauro Krampera Extracellular Vesicle-Dependent Communication Between Mesenchymal Stromal Cells and Immune Effector Cells Frontiers in Cell and Developmental Biology extracellular vesicles exosomes microvesicles mesenchymal stromal cells immune effector cells immunomodulation |
| title | Extracellular Vesicle-Dependent Communication Between Mesenchymal Stromal Cells and Immune Effector Cells |
| title_full | Extracellular Vesicle-Dependent Communication Between Mesenchymal Stromal Cells and Immune Effector Cells |
| title_fullStr | Extracellular Vesicle-Dependent Communication Between Mesenchymal Stromal Cells and Immune Effector Cells |
| title_full_unstemmed | Extracellular Vesicle-Dependent Communication Between Mesenchymal Stromal Cells and Immune Effector Cells |
| title_short | Extracellular Vesicle-Dependent Communication Between Mesenchymal Stromal Cells and Immune Effector Cells |
| title_sort | extracellular vesicle dependent communication between mesenchymal stromal cells and immune effector cells |
| topic | extracellular vesicles exosomes microvesicles mesenchymal stromal cells immune effector cells immunomodulation |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2020.596079/full |
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