Melanoma Tumour Vascularization and Tissue-Resident Endothelial Progenitor Cells
The aggressiveness of solid cancers, such as melanoma, relies on their metastatic potential. It has become evident that this key cause of mortality is largely conferred by the tumour-associated stromal cells, especially endothelial cells. In addition to their essential role in the formation of the t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/17/4216 |
| _version_ | 1797496091371896832 |
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| author | Ghazaleh Hashemi James Dight Kiarash Khosrotehrani Laura Sormani |
| author_facet | Ghazaleh Hashemi James Dight Kiarash Khosrotehrani Laura Sormani |
| author_sort | Ghazaleh Hashemi |
| collection | DOAJ |
| description | The aggressiveness of solid cancers, such as melanoma, relies on their metastatic potential. It has become evident that this key cause of mortality is largely conferred by the tumour-associated stromal cells, especially endothelial cells. In addition to their essential role in the formation of the tumour vasculature, endothelial cells significantly contribute to the establishment of the tumour microenvironment, thus enabling the dissemination of cancer cells. Melanoma tumour vascularization occurs through diverse biological processes. Vasculogenesis is the formation of de novo blood vessels from endothelial progenitor cells (EPCs), and recent research has shown the role of EPCs in melanoma tumour vascularization. A more detailed understanding of the complex role of EPCs and how they contribute to the abnormal vessel structures in tumours is of importance. Moreover, anti-angiogenic drugs have a limited effect on melanoma tumour vascularization, and the role of these drugs on EPCs remains to be clarified. Overall, targeting cancer vasculature remains a challenge, and the role of anti-angiogenic drugs and combination therapies in melanoma, a focus of this review, is an area of extensive exploration. |
| first_indexed | 2024-03-10T01:58:43Z |
| format | Article |
| id | doaj.art-458ca71dc95c435caf4f79a28503cce4 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T01:58:43Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-458ca71dc95c435caf4f79a28503cce42023-11-23T12:51:48ZengMDPI AGCancers2072-66942022-08-011417421610.3390/cancers14174216Melanoma Tumour Vascularization and Tissue-Resident Endothelial Progenitor CellsGhazaleh Hashemi0James Dight1Kiarash Khosrotehrani2Laura Sormani3Experimental Dermatology Group, Dermatology Research Centre, The UQ Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, AustraliaExperimental Dermatology Group, Dermatology Research Centre, The UQ Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, AustraliaExperimental Dermatology Group, Dermatology Research Centre, The UQ Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, AustraliaExperimental Dermatology Group, Dermatology Research Centre, The UQ Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, AustraliaThe aggressiveness of solid cancers, such as melanoma, relies on their metastatic potential. It has become evident that this key cause of mortality is largely conferred by the tumour-associated stromal cells, especially endothelial cells. In addition to their essential role in the formation of the tumour vasculature, endothelial cells significantly contribute to the establishment of the tumour microenvironment, thus enabling the dissemination of cancer cells. Melanoma tumour vascularization occurs through diverse biological processes. Vasculogenesis is the formation of de novo blood vessels from endothelial progenitor cells (EPCs), and recent research has shown the role of EPCs in melanoma tumour vascularization. A more detailed understanding of the complex role of EPCs and how they contribute to the abnormal vessel structures in tumours is of importance. Moreover, anti-angiogenic drugs have a limited effect on melanoma tumour vascularization, and the role of these drugs on EPCs remains to be clarified. Overall, targeting cancer vasculature remains a challenge, and the role of anti-angiogenic drugs and combination therapies in melanoma, a focus of this review, is an area of extensive exploration.https://www.mdpi.com/2072-6694/14/17/4216melanoma vascularizationvasculogenesisendothelial progenitor cellsanti-angiogenic drugs |
| spellingShingle | Ghazaleh Hashemi James Dight Kiarash Khosrotehrani Laura Sormani Melanoma Tumour Vascularization and Tissue-Resident Endothelial Progenitor Cells Cancers melanoma vascularization vasculogenesis endothelial progenitor cells anti-angiogenic drugs |
| title | Melanoma Tumour Vascularization and Tissue-Resident Endothelial Progenitor Cells |
| title_full | Melanoma Tumour Vascularization and Tissue-Resident Endothelial Progenitor Cells |
| title_fullStr | Melanoma Tumour Vascularization and Tissue-Resident Endothelial Progenitor Cells |
| title_full_unstemmed | Melanoma Tumour Vascularization and Tissue-Resident Endothelial Progenitor Cells |
| title_short | Melanoma Tumour Vascularization and Tissue-Resident Endothelial Progenitor Cells |
| title_sort | melanoma tumour vascularization and tissue resident endothelial progenitor cells |
| topic | melanoma vascularization vasculogenesis endothelial progenitor cells anti-angiogenic drugs |
| url | https://www.mdpi.com/2072-6694/14/17/4216 |
| work_keys_str_mv | AT ghazalehhashemi melanomatumourvascularizationandtissueresidentendothelialprogenitorcells AT jamesdight melanomatumourvascularizationandtissueresidentendothelialprogenitorcells AT kiarashkhosrotehrani melanomatumourvascularizationandtissueresidentendothelialprogenitorcells AT laurasormani melanomatumourvascularizationandtissueresidentendothelialprogenitorcells |