Pubescenosides E–K, Seven New Triterpenoid Saponins from the Roots of Ilex pubescens and Their Anti-Inflammatory Activity
Seven new triterpenoid saponins (1–7), together with three known ones (8–10), were isolated from Ilex pubescens. Elucidation of their structures was performed based on high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS), infrared spectra (IR), and nuclear magnet...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-06-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/23/6/1426 |
| _version_ | 1818931564200853504 |
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| author | Xiaoxu Qiao Mengying Ji Yunda Yao Leilei Ma Jinjun Wu Guochao Liao Hua Zhou Zhongqiu Liu Peng Wu |
| author_facet | Xiaoxu Qiao Mengying Ji Yunda Yao Leilei Ma Jinjun Wu Guochao Liao Hua Zhou Zhongqiu Liu Peng Wu |
| author_sort | Xiaoxu Qiao |
| collection | DOAJ |
| description | Seven new triterpenoid saponins (1–7), together with three known ones (8–10), were isolated from Ilex pubescens. Elucidation of their structures was performed based on high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS), infrared spectra (IR), and nuclear magnetic resonance (NMR) spectroscopic data. The anti-inflammatory activity of the isolates toward lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages was investigated. The results demonstrated that compounds 3, 5, and 6 inhibited the expression of inducible nitric oxide synthase (iNOS) protein in comparison with LPS stimulation in RAW264.7 cells. |
| first_indexed | 2024-12-20T04:18:36Z |
| format | Article |
| id | doaj.art-458d4c60e2a745f9a6f019228c283d61 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-20T04:18:36Z |
| publishDate | 2018-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-458d4c60e2a745f9a6f019228c283d612022-12-21T19:53:42ZengMDPI AGMolecules1420-30492018-06-01236142610.3390/molecules23061426molecules23061426Pubescenosides E–K, Seven New Triterpenoid Saponins from the Roots of Ilex pubescens and Their Anti-Inflammatory ActivityXiaoxu Qiao0Mengying Ji1Yunda Yao2Leilei Ma3Jinjun Wu4Guochao Liao5Hua Zhou6Zhongqiu Liu7Peng Wu8Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China, International Institute for Translational Chinese Medicine, University of Chinese Medicine, Guangzhou 510006, ChinaJoint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China, International Institute for Translational Chinese Medicine, University of Chinese Medicine, Guangzhou 510006, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau 999078, ChinaJoint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China, International Institute for Translational Chinese Medicine, University of Chinese Medicine, Guangzhou 510006, ChinaJoint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China, International Institute for Translational Chinese Medicine, University of Chinese Medicine, Guangzhou 510006, ChinaJoint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China, International Institute for Translational Chinese Medicine, University of Chinese Medicine, Guangzhou 510006, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau 999078, ChinaJoint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China, International Institute for Translational Chinese Medicine, University of Chinese Medicine, Guangzhou 510006, ChinaJoint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China, International Institute for Translational Chinese Medicine, University of Chinese Medicine, Guangzhou 510006, ChinaSeven new triterpenoid saponins (1–7), together with three known ones (8–10), were isolated from Ilex pubescens. Elucidation of their structures was performed based on high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS), infrared spectra (IR), and nuclear magnetic resonance (NMR) spectroscopic data. The anti-inflammatory activity of the isolates toward lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages was investigated. The results demonstrated that compounds 3, 5, and 6 inhibited the expression of inducible nitric oxide synthase (iNOS) protein in comparison with LPS stimulation in RAW264.7 cells.http://www.mdpi.com/1420-3049/23/6/1426Ilex pubescensanti-inflammationRAW264.7 |
| spellingShingle | Xiaoxu Qiao Mengying Ji Yunda Yao Leilei Ma Jinjun Wu Guochao Liao Hua Zhou Zhongqiu Liu Peng Wu Pubescenosides E–K, Seven New Triterpenoid Saponins from the Roots of Ilex pubescens and Their Anti-Inflammatory Activity Molecules Ilex pubescens anti-inflammation RAW264.7 |
| title | Pubescenosides E–K, Seven New Triterpenoid Saponins from the Roots of Ilex pubescens and Their Anti-Inflammatory Activity |
| title_full | Pubescenosides E–K, Seven New Triterpenoid Saponins from the Roots of Ilex pubescens and Their Anti-Inflammatory Activity |
| title_fullStr | Pubescenosides E–K, Seven New Triterpenoid Saponins from the Roots of Ilex pubescens and Their Anti-Inflammatory Activity |
| title_full_unstemmed | Pubescenosides E–K, Seven New Triterpenoid Saponins from the Roots of Ilex pubescens and Their Anti-Inflammatory Activity |
| title_short | Pubescenosides E–K, Seven New Triterpenoid Saponins from the Roots of Ilex pubescens and Their Anti-Inflammatory Activity |
| title_sort | pubescenosides e k seven new triterpenoid saponins from the roots of ilex pubescens and their anti inflammatory activity |
| topic | Ilex pubescens anti-inflammation RAW264.7 |
| url | http://www.mdpi.com/1420-3049/23/6/1426 |
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