Evaluation of long-term oncological outcomes of inter-sphincter resection compared with abdominoperineal resection for treatment of ultra-low rectal cancers: a single center 5-year experience
Objectives: Abdominoperineal resection (APR) is considered the gold standard surgical treatment for ultra-low rectal cancer. Anus-preserving alternative procedures have been tested to avoid the need for a permanent colostomy. The present study compares the functional and oncological outcomes of the...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
|
| Series: | Surgery in Practice and Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666262023000372 |
| _version_ | 1827822294097985536 |
|---|---|
| author | FakhroSadat Anaraki Mahdi Alemrajabi Ramin Shekouhi Maryam Sohooli Seyed-Ali Sabz |
| author_facet | FakhroSadat Anaraki Mahdi Alemrajabi Ramin Shekouhi Maryam Sohooli Seyed-Ali Sabz |
| author_sort | FakhroSadat Anaraki |
| collection | DOAJ |
| description | Objectives: Abdominoperineal resection (APR) is considered the gold standard surgical treatment for ultra-low rectal cancer. Anus-preserving alternative procedures have been tested to avoid the need for a permanent colostomy. The present study compares the functional and oncological outcomes of the traditional APR methods with inter-sphincteric resection (ISR). Methods: Sixty patients with ultra-low rectal cancers that underwent tumor resection using the ISR and APR methods were compared retrospectively. Patients' demographic information as well as tumor characteristics were evaluated. All patients were followed after the operation every three months for two years, and then every six months for at least three years. Results: Thirty-four (56.6%) patients were male, and 26 (43.3%) were females, which showed no statistical significance between the two groups. The mean tumor distance from the anal verge in the APR group was 5.11±0.06 cm and in the ISR group was 5.22±1.1 cm. In the APR group, 9 (30%) patients developed primary tumor recurrence, while in the ISR group, 10 (33.3%) patients had relapses. The observed difference was not statistically significant. However, the study showed that patients with a T stage of T2 or higher had a higher probability of tumor recurrence. Conclusion: There is no significant difference in the efficacy of the ISR method compared with the conventional APR for the treatment of ultra-low rectal cancer. |
| first_indexed | 2024-03-12T01:56:00Z |
| format | Article |
| id | doaj.art-458d9bb20b2f4e25bc4ae26d28996c5f |
| institution | Directory Open Access Journal |
| issn | 2666-2620 |
| language | English |
| last_indexed | 2024-03-12T01:56:00Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Surgery in Practice and Science |
| spelling | doaj.art-458d9bb20b2f4e25bc4ae26d28996c5f2023-09-08T04:33:57ZengElsevierSurgery in Practice and Science2666-26202023-09-0114100191Evaluation of long-term oncological outcomes of inter-sphincter resection compared with abdominoperineal resection for treatment of ultra-low rectal cancers: a single center 5-year experienceFakhroSadat Anaraki0Mahdi Alemrajabi1Ramin Shekouhi2Maryam Sohooli3Seyed-Ali Sabz4Department of General Surgery, Shahid Beheshti University of Medical Sciences, Tehran, IranFiroozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, IranColorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IranColorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IranAyatollah Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding author.Objectives: Abdominoperineal resection (APR) is considered the gold standard surgical treatment for ultra-low rectal cancer. Anus-preserving alternative procedures have been tested to avoid the need for a permanent colostomy. The present study compares the functional and oncological outcomes of the traditional APR methods with inter-sphincteric resection (ISR). Methods: Sixty patients with ultra-low rectal cancers that underwent tumor resection using the ISR and APR methods were compared retrospectively. Patients' demographic information as well as tumor characteristics were evaluated. All patients were followed after the operation every three months for two years, and then every six months for at least three years. Results: Thirty-four (56.6%) patients were male, and 26 (43.3%) were females, which showed no statistical significance between the two groups. The mean tumor distance from the anal verge in the APR group was 5.11±0.06 cm and in the ISR group was 5.22±1.1 cm. In the APR group, 9 (30%) patients developed primary tumor recurrence, while in the ISR group, 10 (33.3%) patients had relapses. The observed difference was not statistically significant. However, the study showed that patients with a T stage of T2 or higher had a higher probability of tumor recurrence. Conclusion: There is no significant difference in the efficacy of the ISR method compared with the conventional APR for the treatment of ultra-low rectal cancer.http://www.sciencedirect.com/science/article/pii/S2666262023000372Rectal cancerIntersphincteric resectionAbdominoperineal resectionSurvivalRecurrence |
| spellingShingle | FakhroSadat Anaraki Mahdi Alemrajabi Ramin Shekouhi Maryam Sohooli Seyed-Ali Sabz Evaluation of long-term oncological outcomes of inter-sphincter resection compared with abdominoperineal resection for treatment of ultra-low rectal cancers: a single center 5-year experience Surgery in Practice and Science Rectal cancer Intersphincteric resection Abdominoperineal resection Survival Recurrence |
| title | Evaluation of long-term oncological outcomes of inter-sphincter resection compared with abdominoperineal resection for treatment of ultra-low rectal cancers: a single center 5-year experience |
| title_full | Evaluation of long-term oncological outcomes of inter-sphincter resection compared with abdominoperineal resection for treatment of ultra-low rectal cancers: a single center 5-year experience |
| title_fullStr | Evaluation of long-term oncological outcomes of inter-sphincter resection compared with abdominoperineal resection for treatment of ultra-low rectal cancers: a single center 5-year experience |
| title_full_unstemmed | Evaluation of long-term oncological outcomes of inter-sphincter resection compared with abdominoperineal resection for treatment of ultra-low rectal cancers: a single center 5-year experience |
| title_short | Evaluation of long-term oncological outcomes of inter-sphincter resection compared with abdominoperineal resection for treatment of ultra-low rectal cancers: a single center 5-year experience |
| title_sort | evaluation of long term oncological outcomes of inter sphincter resection compared with abdominoperineal resection for treatment of ultra low rectal cancers a single center 5 year experience |
| topic | Rectal cancer Intersphincteric resection Abdominoperineal resection Survival Recurrence |
| url | http://www.sciencedirect.com/science/article/pii/S2666262023000372 |
| work_keys_str_mv | AT fakhrosadatanaraki evaluationoflongtermoncologicaloutcomesofintersphincterresectioncomparedwithabdominoperinealresectionfortreatmentofultralowrectalcancersasinglecenter5yearexperience AT mahdialemrajabi evaluationoflongtermoncologicaloutcomesofintersphincterresectioncomparedwithabdominoperinealresectionfortreatmentofultralowrectalcancersasinglecenter5yearexperience AT raminshekouhi evaluationoflongtermoncologicaloutcomesofintersphincterresectioncomparedwithabdominoperinealresectionfortreatmentofultralowrectalcancersasinglecenter5yearexperience AT maryamsohooli evaluationoflongtermoncologicaloutcomesofintersphincterresectioncomparedwithabdominoperinealresectionfortreatmentofultralowrectalcancersasinglecenter5yearexperience AT seyedalisabz evaluationoflongtermoncologicaloutcomesofintersphincterresectioncomparedwithabdominoperinealresectionfortreatmentofultralowrectalcancersasinglecenter5yearexperience |