Spectrophotometric Estimation of Ganciclovir in Pharmaceutical Formulations using Alizarin Sulfonic Acid Sodium Salt Reagent
الملص<br /> ABSTRACT <br /> A simple and rapid spectrophotometric method has been developed for the determination of antiviral drug (Ganciclovir) in a bulk sample and in its dosage forms. The method depends on the ion-pair formation reaction of the drug with alizarin sulfonic acid sodium...
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| Format: | Article |
| Language: | Arabic |
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College of Education for Pure Sciences
2013-06-01
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| Series: | مجلة التربية والعلم |
| Subjects: | |
| Online Access: | https://edusj.mosuljournals.com/article_89818_8c5d3bdb086e3776582033d47cf9e175.pdf |
| _version_ | 1811338578076106752 |
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| author | Usra I.S. AL-Neaimy |
| author_facet | Usra I.S. AL-Neaimy |
| author_sort | Usra I.S. AL-Neaimy |
| collection | DOAJ |
| description | الملص<br /> ABSTRACT <br /> A simple and rapid spectrophotometric method has been developed for the determination of antiviral drug (Ganciclovir) in a bulk sample and in its dosage forms. The method depends on the ion-pair formation reaction of the drug with alizarin sulfonic acid sodium salt reagent in aqueous solution to form a pinkish - red color product showing maximum absorbance at 525 nm. Beer's law is obeyed in the concentration range 2 – 100 µg.ml-1 with average recovery (accuracy) 99.80% and precision (RSD) is less than 1.0%. The molar absorptivity is 4.59x103 l.mol-1.cm-1 with LOD 0.17 µg.ml-1 and LOQ 0.56 µg.ml-1. The method is successfully employed for the determination of Ganciclovir in pharmaceutical formulations as an injection and capsule and the results are compatible with both certified values of pharmaceutical formulations and the standard addition method.<br /> Keywords: ganciclovir; spectrophotometric; alizarin sulfonic acid sodium salt. |
| first_indexed | 2024-04-13T18:13:11Z |
| format | Article |
| id | doaj.art-458f3506ae1f4462b60763ada5b2f7c7 |
| institution | Directory Open Access Journal |
| issn | 1812-125X 2664-2530 |
| language | Arabic |
| last_indexed | 2024-04-13T18:13:11Z |
| publishDate | 2013-06-01 |
| publisher | College of Education for Pure Sciences |
| record_format | Article |
| series | مجلة التربية والعلم |
| spelling | doaj.art-458f3506ae1f4462b60763ada5b2f7c72022-12-22T02:35:47ZaraCollege of Education for Pure Sciencesمجلة التربية والعلم1812-125X2664-25302013-06-01262657310.33899/edusj.2013.8981889818Spectrophotometric Estimation of Ganciclovir in Pharmaceutical Formulations using Alizarin Sulfonic Acid Sodium Salt ReagentUsra I.S. AL-Neaimyالملص<br /> ABSTRACT <br /> A simple and rapid spectrophotometric method has been developed for the determination of antiviral drug (Ganciclovir) in a bulk sample and in its dosage forms. The method depends on the ion-pair formation reaction of the drug with alizarin sulfonic acid sodium salt reagent in aqueous solution to form a pinkish - red color product showing maximum absorbance at 525 nm. Beer's law is obeyed in the concentration range 2 – 100 µg.ml-1 with average recovery (accuracy) 99.80% and precision (RSD) is less than 1.0%. The molar absorptivity is 4.59x103 l.mol-1.cm-1 with LOD 0.17 µg.ml-1 and LOQ 0.56 µg.ml-1. The method is successfully employed for the determination of Ganciclovir in pharmaceutical formulations as an injection and capsule and the results are compatible with both certified values of pharmaceutical formulations and the standard addition method.<br /> Keywords: ganciclovir; spectrophotometric; alizarin sulfonic acid sodium salt.https://edusj.mosuljournals.com/article_89818_8c5d3bdb086e3776582033d47cf9e175.pdfspectrophotometric estimationpharmaceutical formulationsalizarin sulfonic |
| spellingShingle | Usra I.S. AL-Neaimy Spectrophotometric Estimation of Ganciclovir in Pharmaceutical Formulations using Alizarin Sulfonic Acid Sodium Salt Reagent مجلة التربية والعلم spectrophotometric estimation pharmaceutical formulations alizarin sulfonic |
| title | Spectrophotometric Estimation of Ganciclovir in Pharmaceutical Formulations using Alizarin Sulfonic Acid Sodium Salt Reagent |
| title_full | Spectrophotometric Estimation of Ganciclovir in Pharmaceutical Formulations using Alizarin Sulfonic Acid Sodium Salt Reagent |
| title_fullStr | Spectrophotometric Estimation of Ganciclovir in Pharmaceutical Formulations using Alizarin Sulfonic Acid Sodium Salt Reagent |
| title_full_unstemmed | Spectrophotometric Estimation of Ganciclovir in Pharmaceutical Formulations using Alizarin Sulfonic Acid Sodium Salt Reagent |
| title_short | Spectrophotometric Estimation of Ganciclovir in Pharmaceutical Formulations using Alizarin Sulfonic Acid Sodium Salt Reagent |
| title_sort | spectrophotometric estimation of ganciclovir in pharmaceutical formulations using alizarin sulfonic acid sodium salt reagent |
| topic | spectrophotometric estimation pharmaceutical formulations alizarin sulfonic |
| url | https://edusj.mosuljournals.com/article_89818_8c5d3bdb086e3776582033d47cf9e175.pdf |
| work_keys_str_mv | AT usraisalneaimy spectrophotometricestimationofganciclovirinpharmaceuticalformulationsusingalizarinsulfonicacidsodiumsaltreagent |