Culturing of Cardiac Fibroblasts in Engineered Heart Matrix Reduces Myofibroblast Differentiation but Maintains Their Response to Cyclic Stretch and Transforming Growth Factor β1

Culturing of Cardiac Fibroblasts in Engineered Heart Matrix Reduces Myofibroblast Differentiation but Maintains Their Response to Cyclic Stretch and Transforming Growth Factor β1

Isolation and culturing of cardiac fibroblasts (CF) induces rapid differentiation toward a myofibroblast phenotype, which is partly mediated by the high substrate stiffness of the culture plates. In the present study, a 3D model of Engineered Heart Matrix (EHM) of physiological stiffness (Youngs mod...

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Bibliographic Details
Main Authors: Meike C. Ploeg, Chantal Munts, Tayeba Seddiqi, Tim J. L. ten Brink, Jonathan Breemhaar, Lorenzo Moroni, Frits. W. Prinzen, Frans. A. van Nieuwenhoven
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Bioengineering
Subjects:
stiffness
stretch
cardiac fibroblast
three dimensional
Online Access:https://www.mdpi.com/2306-5354/9/10/551

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