Injectable, Antioxidative, and Tissue‐Adhesive Nanocomposite Hydrogel as a Potential Treatment for Inner Retina Injuries
Abstract Reactive oxygen species (ROS) have been recognized as prevalent contributors to the development of inner retinal injuries including optic neuropathies such as glaucoma, non‐arteritic anterior ischemic optic neuropathy, traumatic optic neuropathy, and Leber hereditary optic neuropathy, among...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202308635 |
| _version_ | 1797254996672118784 |
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| author | Yi‐Chen Liu Yi‐Ke Lin Yu‐Ting Lin Che‐Wei Lin Guan‐Yu Lan Yu‐Chia Su Fung‐Rong Hu Kai‐Hsiang Chang Vincent Chen Yi‐Cheun Yeh Ta‐Ching Chen Jiashing Yu |
| author_facet | Yi‐Chen Liu Yi‐Ke Lin Yu‐Ting Lin Che‐Wei Lin Guan‐Yu Lan Yu‐Chia Su Fung‐Rong Hu Kai‐Hsiang Chang Vincent Chen Yi‐Cheun Yeh Ta‐Ching Chen Jiashing Yu |
| author_sort | Yi‐Chen Liu |
| collection | DOAJ |
| description | Abstract Reactive oxygen species (ROS) have been recognized as prevalent contributors to the development of inner retinal injuries including optic neuropathies such as glaucoma, non‐arteritic anterior ischemic optic neuropathy, traumatic optic neuropathy, and Leber hereditary optic neuropathy, among others. This underscores the pivotal significance of oxidative stress in the damage inflicted upon retinal tissue. To combat ROS‐related challenges, this study focuses on creating an injectable and tissue‐adhesive hydrogel with tailored antioxidant properties for retinal applications. GelCA, a gelatin‐modified hydrogel with photo‐crosslinkable and injectable properties, is developed. To enhance its antioxidant capabilities, curcumin‐loaded polydopamine nanoparticles (Cur@PDA NPs) are incorporated into the GelCA matrix, resulting in a multifunctional nanocomposite hydrogel referred to as Cur@PDA@GelCA. This hydrogel exhibits excellent biocompatibility in both in vitro and in vivo assessments, along with enhanced tissue adhesion facilitated by NPs in an in vivo model. Importantly, Cur@PDA@GelCA demonstrates the potential to mitigate oxidative stress when administered via intravitreal injection in retinal injury models such as the optic nerve crush model. These findings underscore its promise in advancing retinal tissue engineering and providing an innovative strategy for acute neuroprotection in the context of inner retinal injuries. |
| first_indexed | 2024-04-24T21:58:50Z |
| format | Article |
| id | doaj.art-4596eabf249643e3bab84665188ea660 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-24T21:58:50Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-4596eabf249643e3bab84665188ea6602024-03-20T12:56:12ZengWileyAdvanced Science2198-38442024-03-011111n/an/a10.1002/advs.202308635Injectable, Antioxidative, and Tissue‐Adhesive Nanocomposite Hydrogel as a Potential Treatment for Inner Retina InjuriesYi‐Chen Liu0Yi‐Ke Lin1Yu‐Ting Lin2Che‐Wei Lin3Guan‐Yu Lan4Yu‐Chia Su5Fung‐Rong Hu6Kai‐Hsiang Chang7Vincent Chen8Yi‐Cheun Yeh9Ta‐Ching Chen10Jiashing Yu11Department of Chemical Engineering National Taiwan University Taipei 10617 TaiwanDepartment of Ophthalmology College of Medicine National Taiwan University Taipei 100233 TaiwanDepartment of Chemical Engineering National Taiwan University Taipei 10617 TaiwanDepartment of Chemical Engineering National Taiwan University Taipei 10617 TaiwanDepartment of Chemical Engineering National Taiwan University Taipei 10617 TaiwanInstitute of Polymer Science and Engineering National Taiwan University Taipei 10617 TaiwanDepartment of Ophthalmology College of Medicine National Taiwan University Taipei 100233 TaiwanDepartment of Chemical Engineering National Taiwan University Taipei 10617 TaiwanDepartment of Chemical Engineering National Taiwan University Taipei 10617 TaiwanInstitute of Polymer Science and Engineering National Taiwan University Taipei 10617 TaiwanDepartment of Ophthalmology National Taiwan University Hospital Taipei 100225 TaiwanDepartment of Chemical Engineering National Taiwan University Taipei 10617 TaiwanAbstract Reactive oxygen species (ROS) have been recognized as prevalent contributors to the development of inner retinal injuries including optic neuropathies such as glaucoma, non‐arteritic anterior ischemic optic neuropathy, traumatic optic neuropathy, and Leber hereditary optic neuropathy, among others. This underscores the pivotal significance of oxidative stress in the damage inflicted upon retinal tissue. To combat ROS‐related challenges, this study focuses on creating an injectable and tissue‐adhesive hydrogel with tailored antioxidant properties for retinal applications. GelCA, a gelatin‐modified hydrogel with photo‐crosslinkable and injectable properties, is developed. To enhance its antioxidant capabilities, curcumin‐loaded polydopamine nanoparticles (Cur@PDA NPs) are incorporated into the GelCA matrix, resulting in a multifunctional nanocomposite hydrogel referred to as Cur@PDA@GelCA. This hydrogel exhibits excellent biocompatibility in both in vitro and in vivo assessments, along with enhanced tissue adhesion facilitated by NPs in an in vivo model. Importantly, Cur@PDA@GelCA demonstrates the potential to mitigate oxidative stress when administered via intravitreal injection in retinal injury models such as the optic nerve crush model. These findings underscore its promise in advancing retinal tissue engineering and providing an innovative strategy for acute neuroprotection in the context of inner retinal injuries.https://doi.org/10.1002/advs.202308635antioxidant hydrogelgelatininjectable hydrogelnanoparticlesoptic nervephoto‐crosslinkable |
| spellingShingle | Yi‐Chen Liu Yi‐Ke Lin Yu‐Ting Lin Che‐Wei Lin Guan‐Yu Lan Yu‐Chia Su Fung‐Rong Hu Kai‐Hsiang Chang Vincent Chen Yi‐Cheun Yeh Ta‐Ching Chen Jiashing Yu Injectable, Antioxidative, and Tissue‐Adhesive Nanocomposite Hydrogel as a Potential Treatment for Inner Retina Injuries Advanced Science antioxidant hydrogel gelatin injectable hydrogel nanoparticles optic nerve photo‐crosslinkable |
| title | Injectable, Antioxidative, and Tissue‐Adhesive Nanocomposite Hydrogel as a Potential Treatment for Inner Retina Injuries |
| title_full | Injectable, Antioxidative, and Tissue‐Adhesive Nanocomposite Hydrogel as a Potential Treatment for Inner Retina Injuries |
| title_fullStr | Injectable, Antioxidative, and Tissue‐Adhesive Nanocomposite Hydrogel as a Potential Treatment for Inner Retina Injuries |
| title_full_unstemmed | Injectable, Antioxidative, and Tissue‐Adhesive Nanocomposite Hydrogel as a Potential Treatment for Inner Retina Injuries |
| title_short | Injectable, Antioxidative, and Tissue‐Adhesive Nanocomposite Hydrogel as a Potential Treatment for Inner Retina Injuries |
| title_sort | injectable antioxidative and tissue adhesive nanocomposite hydrogel as a potential treatment for inner retina injuries |
| topic | antioxidant hydrogel gelatin injectable hydrogel nanoparticles optic nerve photo‐crosslinkable |
| url | https://doi.org/10.1002/advs.202308635 |
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