Hydromethanolic Extracts from <i>Adansonia digitata</i> L. Edible Parts Positively Modulate Pathophysiological Mechanisms Related to the Metabolic Syndrome
Metabolic syndrome includes a cluster of risk factors for many pathological conditions, including hyperglycemia, abdominal obesity, hyperlipidemia, and hypertension. <i>Adansonia digitata</i> L. (also known as baobab) is used in traditional African Medicine and recent studies showed that...
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MDPI AG
2020-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/12/2858 |
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| author | Stefania Cicolari Marco Dacrema Arold Jorel Tsetegho Sokeng Jianbo Xiao Achille Parfait Atchan Nwakiban Carmen Di Giovanni Cristina Santarcangelo Paolo Magni Maria Daglia |
| author_facet | Stefania Cicolari Marco Dacrema Arold Jorel Tsetegho Sokeng Jianbo Xiao Achille Parfait Atchan Nwakiban Carmen Di Giovanni Cristina Santarcangelo Paolo Magni Maria Daglia |
| author_sort | Stefania Cicolari |
| collection | DOAJ |
| description | Metabolic syndrome includes a cluster of risk factors for many pathological conditions, including hyperglycemia, abdominal obesity, hyperlipidemia, and hypertension. <i>Adansonia digitata</i> L. (also known as baobab) is used in traditional African Medicine and recent studies showed that it improves the metabolism of carbohydrates and lipids. The aim of this study is to investigate the mechanisms of action associated with the beneficial effects of extracts from the edible parts of baobab (fruit pulp, leaves, raw and toasted seeds), evaluating their inhibitory activity against: alpha-amylase, alpha-glucosidase, angiotensin-converting enzyme, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, and pancreatic lipase. Baobab fruit pulp and leaf extracts resulted to be the most active ones and were then tested on the differentiation process of SW-872 human liposarcoma cells to mature adipocytes. The addition of these latter extracts did not affect triglyceride accumulation, indicating a neutral impact on this parameter. The findings here reported help to explain the growing amount of evidence on the biological properties of baobab and provide suggestions about their use in food and nutraceutical fields. |
| first_indexed | 2024-03-10T18:59:07Z |
| format | Article |
| id | doaj.art-4598a5fae3b64a98bc21da9ff08005a2 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T18:59:07Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4598a5fae3b64a98bc21da9ff08005a22023-11-20T04:30:21ZengMDPI AGMolecules1420-30492020-06-012512285810.3390/molecules25122858Hydromethanolic Extracts from <i>Adansonia digitata</i> L. Edible Parts Positively Modulate Pathophysiological Mechanisms Related to the Metabolic SyndromeStefania Cicolari0Marco Dacrema1Arold Jorel Tsetegho Sokeng2Jianbo Xiao3Achille Parfait Atchan Nwakiban4Carmen Di Giovanni5Cristina Santarcangelo6Paolo Magni7Maria Daglia8Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, ItalyDepartment of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyInternational Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Biochemistry, Faculty of Science, University of Dschang, PO Box 67, Dchang, CameroonDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, ItalyDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, ItalyDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, ItalyMetabolic syndrome includes a cluster of risk factors for many pathological conditions, including hyperglycemia, abdominal obesity, hyperlipidemia, and hypertension. <i>Adansonia digitata</i> L. (also known as baobab) is used in traditional African Medicine and recent studies showed that it improves the metabolism of carbohydrates and lipids. The aim of this study is to investigate the mechanisms of action associated with the beneficial effects of extracts from the edible parts of baobab (fruit pulp, leaves, raw and toasted seeds), evaluating their inhibitory activity against: alpha-amylase, alpha-glucosidase, angiotensin-converting enzyme, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, and pancreatic lipase. Baobab fruit pulp and leaf extracts resulted to be the most active ones and were then tested on the differentiation process of SW-872 human liposarcoma cells to mature adipocytes. The addition of these latter extracts did not affect triglyceride accumulation, indicating a neutral impact on this parameter. The findings here reported help to explain the growing amount of evidence on the biological properties of baobab and provide suggestions about their use in food and nutraceutical fields.https://www.mdpi.com/1420-3049/25/12/2858<i>Adansonia digitata</i> L.baobab edible partsdigestive enzyme inhibitionACE inhibitionHMG-CoA reductase inhibitionSW-872 preadipocytes |
| spellingShingle | Stefania Cicolari Marco Dacrema Arold Jorel Tsetegho Sokeng Jianbo Xiao Achille Parfait Atchan Nwakiban Carmen Di Giovanni Cristina Santarcangelo Paolo Magni Maria Daglia Hydromethanolic Extracts from <i>Adansonia digitata</i> L. Edible Parts Positively Modulate Pathophysiological Mechanisms Related to the Metabolic Syndrome Molecules <i>Adansonia digitata</i> L. baobab edible parts digestive enzyme inhibition ACE inhibition HMG-CoA reductase inhibition SW-872 preadipocytes |
| title | Hydromethanolic Extracts from <i>Adansonia digitata</i> L. Edible Parts Positively Modulate Pathophysiological Mechanisms Related to the Metabolic Syndrome |
| title_full | Hydromethanolic Extracts from <i>Adansonia digitata</i> L. Edible Parts Positively Modulate Pathophysiological Mechanisms Related to the Metabolic Syndrome |
| title_fullStr | Hydromethanolic Extracts from <i>Adansonia digitata</i> L. Edible Parts Positively Modulate Pathophysiological Mechanisms Related to the Metabolic Syndrome |
| title_full_unstemmed | Hydromethanolic Extracts from <i>Adansonia digitata</i> L. Edible Parts Positively Modulate Pathophysiological Mechanisms Related to the Metabolic Syndrome |
| title_short | Hydromethanolic Extracts from <i>Adansonia digitata</i> L. Edible Parts Positively Modulate Pathophysiological Mechanisms Related to the Metabolic Syndrome |
| title_sort | hydromethanolic extracts from i adansonia digitata i l edible parts positively modulate pathophysiological mechanisms related to the metabolic syndrome |
| topic | <i>Adansonia digitata</i> L. baobab edible parts digestive enzyme inhibition ACE inhibition HMG-CoA reductase inhibition SW-872 preadipocytes |
| url | https://www.mdpi.com/1420-3049/25/12/2858 |
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