Plant-Derived Natural Products: A Source for Drug Discovery and Development
For thousands of years, nature has been a source of medical substances, and an astounding numeral of contemporary remedies have been identified from natural origins. Plants have long been used as folk herbal medicines to treat various disorders, and their different natural products have inspired the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Drugs and Drug Candidates |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2813-2998/3/1/11 |
| _version_ | 1827306550421618688 |
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| author | Noureddine Chaachouay Lahcen Zidane |
| author_facet | Noureddine Chaachouay Lahcen Zidane |
| author_sort | Noureddine Chaachouay |
| collection | DOAJ |
| description | For thousands of years, nature has been a source of medical substances, and an astounding numeral of contemporary remedies have been identified from natural origins. Plants have long been used as folk herbal medicines to treat various disorders, and their different natural products have inspired the design, discovery, and development of new drugs. With the invention of recent molecular targets based on proteins, there is a growing need for fresh chemical diversification in screening. Natural products will play a vital part in supplying this need via the continuous exploration of global biodiversity, the majority of which remains unexplored. Even though drug discovery from medicinal plants remains an important source of novel therapeutic leads, various hurdles exist, including identifying and executing suitable high-throughput screening bioassays, scaling up the supply of bioactive molecules, and acquiring plant materials. Investigating these natural resources takes multi-disciplinary, nationwide, and global partnerships in design, synthesis, discovery, and drug development techniques. This review article discusses current advancements and future approaches for discovering natural items such as health- and wellness-promoting remedies. It also summarizes strategies to unify the therapeutic use of plant-derived natural products worldwide to support future drug discoveries derived from plant sources. |
| first_indexed | 2024-04-24T18:24:26Z |
| format | Article |
| id | doaj.art-45998eadac644ca89ef4d9c24dc83e55 |
| institution | Directory Open Access Journal |
| issn | 2813-2998 |
| language | English |
| last_indexed | 2024-04-24T18:24:26Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Drugs and Drug Candidates |
| spelling | doaj.art-45998eadac644ca89ef4d9c24dc83e552024-03-27T13:32:56ZengMDPI AGDrugs and Drug Candidates2813-29982024-02-013118420710.3390/ddc3010011Plant-Derived Natural Products: A Source for Drug Discovery and DevelopmentNoureddine Chaachouay0Lahcen Zidane1Agri-Food and Health Laboratory (AFHL), École Supérieure Normale, Hassan First University, P.O. Box 382, Settat 26000, MoroccoPlant, Animal Productions and Agro-Industry Laboratory, Department of Biology, Faculty of Sciences, Ibn Tofail University, P.O. Box 133, Kenitra 14000, MoroccoFor thousands of years, nature has been a source of medical substances, and an astounding numeral of contemporary remedies have been identified from natural origins. Plants have long been used as folk herbal medicines to treat various disorders, and their different natural products have inspired the design, discovery, and development of new drugs. With the invention of recent molecular targets based on proteins, there is a growing need for fresh chemical diversification in screening. Natural products will play a vital part in supplying this need via the continuous exploration of global biodiversity, the majority of which remains unexplored. Even though drug discovery from medicinal plants remains an important source of novel therapeutic leads, various hurdles exist, including identifying and executing suitable high-throughput screening bioassays, scaling up the supply of bioactive molecules, and acquiring plant materials. Investigating these natural resources takes multi-disciplinary, nationwide, and global partnerships in design, synthesis, discovery, and drug development techniques. This review article discusses current advancements and future approaches for discovering natural items such as health- and wellness-promoting remedies. It also summarizes strategies to unify the therapeutic use of plant-derived natural products worldwide to support future drug discoveries derived from plant sources.https://www.mdpi.com/2813-2998/3/1/11drug discoverymedicinal plantmedicinenatural productspharmacy |
| spellingShingle | Noureddine Chaachouay Lahcen Zidane Plant-Derived Natural Products: A Source for Drug Discovery and Development Drugs and Drug Candidates drug discovery medicinal plant medicine natural products pharmacy |
| title | Plant-Derived Natural Products: A Source for Drug Discovery and Development |
| title_full | Plant-Derived Natural Products: A Source for Drug Discovery and Development |
| title_fullStr | Plant-Derived Natural Products: A Source for Drug Discovery and Development |
| title_full_unstemmed | Plant-Derived Natural Products: A Source for Drug Discovery and Development |
| title_short | Plant-Derived Natural Products: A Source for Drug Discovery and Development |
| title_sort | plant derived natural products a source for drug discovery and development |
| topic | drug discovery medicinal plant medicine natural products pharmacy |
| url | https://www.mdpi.com/2813-2998/3/1/11 |
| work_keys_str_mv | AT noureddinechaachouay plantderivednaturalproductsasourcefordrugdiscoveryanddevelopment AT lahcenzidane plantderivednaturalproductsasourcefordrugdiscoveryanddevelopment |