Osteoblast-Derived Matrix Vesicles Exhibit Exosomal Traits and a Unique Subset of microRNA: Their Caveolae-Dependent Endocytosis Results in Reduced Osteogenic Differentiation

Osteoblast-Derived Matrix Vesicles Exhibit Exosomal Traits and a Unique Subset of microRNA: Their Caveolae-Dependent Endocytosis Results in Reduced Osteogenic Differentiation

Matrix vesicles (MVs) are nano-sized extracellular vesicles that are anchored in the extracellular matrix (ECM). In addition to playing a role in biomineralization, osteoblast-derived MVs were recently suggested to have regulatory duties. The aims of this study were to establish the characteristics...

Full description

Bibliographic Details
Main Authors: Anne M. Skelton, D. Joshua Cohen, Barbara D. Boyan, Zvi Schwartz
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
matrix vesicles
extracellular vesicles
osteoblasts
osteogenesis
endocytosis
differentiation
Online Access:https://www.mdpi.com/1422-0067/24/16/12770

Similar Items

Similar Items