Transgenic expression of nonclassically secreted FGF suppresses kidney repair.

Transgenic expression of nonclassically secreted FGF suppresses kidney repair.

FGF1 is a signal peptide-less nonclassically released growth factor that is involved in angiogenesis, tissue repair, inflammation, and carcinogenesis. The effects of nonclassical FGF export in vivo are not sufficiently studied. We produced transgenic mice expressing FGF1 in endothelial cells (EC), w...

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Bibliographic Details
Main Authors: Aleksandr Kirov, Maria Duarte, Justin Guay, Michele Karolak, Cong Yan, Leif Oxburgh, Igor Prudovsky
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3351418?pdf=render

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