C-Reactive protein level in morbidly obese patients before and after bariatric surgery
Background: Human obesity is associated with a proinflammatory state and an elevated level of mediators, such as C-reactive protein (CRP). Objectives: To establish CRP levels as baseline preoperative values and then at 6 months after bariatric surgery, as well as to determine the changes in weight,...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-04-01
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| Series: | Revista de Gastroenterología de México (English Edition) |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2255534X14000437 |
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| author | M.E. Rojano-Rodríguez C. Valenzuela-Salazar L.E. Cárdenas-Lailson L.S. Romero Loera M. Torres-Olalde M. Moreno-Portillo |
| author_facet | M.E. Rojano-Rodríguez C. Valenzuela-Salazar L.E. Cárdenas-Lailson L.S. Romero Loera M. Torres-Olalde M. Moreno-Portillo |
| author_sort | M.E. Rojano-Rodríguez |
| collection | DOAJ |
| description | Background: Human obesity is associated with a proinflammatory state and an elevated level of mediators, such as C-reactive protein (CRP).
Objectives: To establish CRP levels as baseline preoperative values and then at 6 months after bariatric surgery, as well as to determine the changes in weight, body mass index (BMI), leukocytes, and glycemia.
Materials and methods: An observational, analytical, retrospective, longitudinal, and open study was conducted. Serum CRP values were measured in 36 adults presenting with morbid obesity, and their baseline relation to weight, BMI, leukocytes, and glycemia was determined; the relation to the same parameters was established again, 6 months after bariatric surgery.
Results: The mean and standard deviation of preoperative and postoperative CRP (mg/L) was 1.15 ± 0.86 and 0.34 ± 0.28, respectively with p < 0.0001; weight (kg) 112.10 ± 22.91 and 84.82 ± 17.11, p = 0.0443; BMI (kg/m2) 42.48 ± 5.97 and 32.2 ± 4.79, p = 0.0988; glucose (mg/dL) 100.58 ± 17.82 and 87.11 ± 8.49, p < 0.0001, and leukocytes (× 103/mm3) 8.62 ± 1.69 and 6.99 ± 1.56, p = 0.3192.
Baseline CRP only correlated with weight and BMI (p = 0.047 and p = 0.027 respectively) and there was no correlation between postoperative CRP and the evaluated parameters.
Conclusions: Preoperative CRP had a significant lineal relation to weight and body mass index. Patients who underwent bariatric surgery had a significant decrease in CRP, weight, and fasting glucose at 6 months after surgery. |
| first_indexed | 2024-12-11T07:14:41Z |
| format | Article |
| id | doaj.art-459a779376b443419b3305cd5f0eac3d |
| institution | Directory Open Access Journal |
| issn | 2255-534X |
| language | English |
| last_indexed | 2024-12-11T07:14:41Z |
| publishDate | 2014-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Revista de Gastroenterología de México (English Edition) |
| spelling | doaj.art-459a779376b443419b3305cd5f0eac3d2022-12-22T01:16:16ZengElsevierRevista de Gastroenterología de México (English Edition)2255-534X2014-04-01792909510.1016/j.rgmxen.2013.11.002C-Reactive protein level in morbidly obese patients before and after bariatric surgeryM.E. Rojano-RodríguezC. Valenzuela-SalazarL.E. Cárdenas-LailsonL.S. Romero LoeraM. Torres-OlaldeM. Moreno-PortilloBackground: Human obesity is associated with a proinflammatory state and an elevated level of mediators, such as C-reactive protein (CRP). Objectives: To establish CRP levels as baseline preoperative values and then at 6 months after bariatric surgery, as well as to determine the changes in weight, body mass index (BMI), leukocytes, and glycemia. Materials and methods: An observational, analytical, retrospective, longitudinal, and open study was conducted. Serum CRP values were measured in 36 adults presenting with morbid obesity, and their baseline relation to weight, BMI, leukocytes, and glycemia was determined; the relation to the same parameters was established again, 6 months after bariatric surgery. Results: The mean and standard deviation of preoperative and postoperative CRP (mg/L) was 1.15 ± 0.86 and 0.34 ± 0.28, respectively with p < 0.0001; weight (kg) 112.10 ± 22.91 and 84.82 ± 17.11, p = 0.0443; BMI (kg/m2) 42.48 ± 5.97 and 32.2 ± 4.79, p = 0.0988; glucose (mg/dL) 100.58 ± 17.82 and 87.11 ± 8.49, p < 0.0001, and leukocytes (× 103/mm3) 8.62 ± 1.69 and 6.99 ± 1.56, p = 0.3192. Baseline CRP only correlated with weight and BMI (p = 0.047 and p = 0.027 respectively) and there was no correlation between postoperative CRP and the evaluated parameters. Conclusions: Preoperative CRP had a significant lineal relation to weight and body mass index. Patients who underwent bariatric surgery had a significant decrease in CRP, weight, and fasting glucose at 6 months after surgery.http://www.sciencedirect.com/science/article/pii/S2255534X14000437C-reactive proteinObesityBariatric surgery |
| spellingShingle | M.E. Rojano-Rodríguez C. Valenzuela-Salazar L.E. Cárdenas-Lailson L.S. Romero Loera M. Torres-Olalde M. Moreno-Portillo C-Reactive protein level in morbidly obese patients before and after bariatric surgery Revista de Gastroenterología de México (English Edition) C-reactive protein Obesity Bariatric surgery |
| title | C-Reactive protein level in morbidly obese patients before and after bariatric surgery |
| title_full | C-Reactive protein level in morbidly obese patients before and after bariatric surgery |
| title_fullStr | C-Reactive protein level in morbidly obese patients before and after bariatric surgery |
| title_full_unstemmed | C-Reactive protein level in morbidly obese patients before and after bariatric surgery |
| title_short | C-Reactive protein level in morbidly obese patients before and after bariatric surgery |
| title_sort | c reactive protein level in morbidly obese patients before and after bariatric surgery |
| topic | C-reactive protein Obesity Bariatric surgery |
| url | http://www.sciencedirect.com/science/article/pii/S2255534X14000437 |
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