Stevioside Prevents Wear Particle-Induced Osteolysis by Inhibiting Osteoclastogenesis and Inflammatory Response via the Suppression of TAK1 Activation

Stevioside Prevents Wear Particle-Induced Osteolysis by Inhibiting Osteoclastogenesis and Inflammatory Response via the Suppression of TAK1 Activation

Aseptic loosening and periprosthetic osteolysis are the leading causes of total joint arthroplasty failure, which occurs as a result of chronic inflammatory response and enhanced osteoclast activity. Here we showed that stevioside, a natural compound isolated from Stevia rebaudiana, exhibited preven...

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Bibliographic Details
Main Authors: Jiahong Meng, Chenhe Zhou, Bin Hu, Mengmeng Luo, Yute Yang, Yangxin Wang, Wei Wang, Guangyao Jiang, Jianqiao Hong, Sihao Li, Haobo Wu, Shigui Yan, Weiqi Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Pharmacology
Subjects:
aseptic loosening
osteoclast
NF-κB – nuclear factor-kappa B
MAPK
TAK1
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01053/full

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