Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta‐Analysis
Background Cerebral small vessel disease (cSVD) is a major contributing factor to ischemic stroke and dementia. However, the vascular pathologies of cSVD remain inconclusive. The aim of this systematic review and meta‐analysis was to characterize the associations between cSVD and cerebrovascular rea...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.123.032616 |
| _version_ | 1797403631239036928 |
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| author | Britton C. Scheuermann Shannon K. Parr Kiana M. Schulze Olivia N. Kunkel Vanessa‐Rose G. Turpin Jia Liang Carl J. Ade |
| author_facet | Britton C. Scheuermann Shannon K. Parr Kiana M. Schulze Olivia N. Kunkel Vanessa‐Rose G. Turpin Jia Liang Carl J. Ade |
| author_sort | Britton C. Scheuermann |
| collection | DOAJ |
| description | Background Cerebral small vessel disease (cSVD) is a major contributing factor to ischemic stroke and dementia. However, the vascular pathologies of cSVD remain inconclusive. The aim of this systematic review and meta‐analysis was to characterize the associations between cSVD and cerebrovascular reactivity (CVR), cerebral autoregulation, and arterial stiffness (AS). Methods and Results MEDLINE, Web of Science, and Embase were searched from inception to September 2023 for studies reporting CVR, cerebral autoregulation, or AS in relation to radiological markers of cSVD. Data were extracted in predefined tables, reviewed, and meta‐analyses performed using inverse‐variance random effects models to determine pooled odds ratios (ORs). A total of 1611 studies were identified; 142 were included in the systematic review, of which 60 had data available for meta‐analyses. Systematic review revealed that CVR, cerebral autoregulation, and AS were consistently associated with cSVD (80.4%, 78.6%, and 85.4% of studies, respectively). Meta‐analysis in 7 studies (536 participants, 32.9% women) revealed a borderline association between impaired CVR and cSVD (OR, 2.26 [95% CI, 0.99–5.14]; P=0.05). In 37 studies (27 952 participants, 53.0% women) increased AS, per SD, was associated with cSVD (OR, 1.24 [95% CI, 1.15–1.33]; P<0.01). Meta‐regression adjusted for comorbidities accounted for one‐third of the AS model variance (R2=29.4%, Pmoderators=0.02). Subgroup analysis of AS studies demonstrated an association with white matter hyperintensities (OR, 1.42 [95% CI, 1.18–1.70]; P<0.01). Conclusions The collective findings of the present systematic review and meta‐analyses suggest an association between cSVD and impaired CVR and elevated AS. However, longitudinal investigations into vascular stiffness and regulatory function as possible risk factors for cSVD remain warranted. |
| first_indexed | 2024-03-09T02:42:10Z |
| format | Article |
| id | doaj.art-459f6046c61244f0b178f672a7e82834 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-03-09T02:42:10Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-459f6046c61244f0b178f672a7e828342023-12-06T02:49:39ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802023-12-01122310.1161/JAHA.123.032616Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta‐AnalysisBritton C. Scheuermann0Shannon K. Parr1Kiana M. Schulze2Olivia N. Kunkel3Vanessa‐Rose G. Turpin4Jia Liang5Carl J. Ade6Department of Kinesiology Kansas State University Manhattan KS USADepartment of Kinesiology Kansas State University Manhattan KS USADepartment of Kinesiology Kansas State University Manhattan KS USADepartment of Kinesiology Kansas State University Manhattan KS USADepartment of Kinesiology Kansas State University Manhattan KS USADepartment of Biostatistics, St. Jude Children’s Research Hospital Memphis TN USADepartment of Kinesiology Kansas State University Manhattan KS USABackground Cerebral small vessel disease (cSVD) is a major contributing factor to ischemic stroke and dementia. However, the vascular pathologies of cSVD remain inconclusive. The aim of this systematic review and meta‐analysis was to characterize the associations between cSVD and cerebrovascular reactivity (CVR), cerebral autoregulation, and arterial stiffness (AS). Methods and Results MEDLINE, Web of Science, and Embase were searched from inception to September 2023 for studies reporting CVR, cerebral autoregulation, or AS in relation to radiological markers of cSVD. Data were extracted in predefined tables, reviewed, and meta‐analyses performed using inverse‐variance random effects models to determine pooled odds ratios (ORs). A total of 1611 studies were identified; 142 were included in the systematic review, of which 60 had data available for meta‐analyses. Systematic review revealed that CVR, cerebral autoregulation, and AS were consistently associated with cSVD (80.4%, 78.6%, and 85.4% of studies, respectively). Meta‐analysis in 7 studies (536 participants, 32.9% women) revealed a borderline association between impaired CVR and cSVD (OR, 2.26 [95% CI, 0.99–5.14]; P=0.05). In 37 studies (27 952 participants, 53.0% women) increased AS, per SD, was associated with cSVD (OR, 1.24 [95% CI, 1.15–1.33]; P<0.01). Meta‐regression adjusted for comorbidities accounted for one‐third of the AS model variance (R2=29.4%, Pmoderators=0.02). Subgroup analysis of AS studies demonstrated an association with white matter hyperintensities (OR, 1.42 [95% CI, 1.18–1.70]; P<0.01). Conclusions The collective findings of the present systematic review and meta‐analyses suggest an association between cSVD and impaired CVR and elevated AS. However, longitudinal investigations into vascular stiffness and regulatory function as possible risk factors for cSVD remain warranted.https://www.ahajournals.org/doi/10.1161/JAHA.123.032616arterial stiffnesscerebral autoregulationcerebral small vessel diseasecerebrovascular reactivity |
| spellingShingle | Britton C. Scheuermann Shannon K. Parr Kiana M. Schulze Olivia N. Kunkel Vanessa‐Rose G. Turpin Jia Liang Carl J. Ade Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta‐Analysis Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease arterial stiffness cerebral autoregulation cerebral small vessel disease cerebrovascular reactivity |
| title | Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta‐Analysis |
| title_full | Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta‐Analysis |
| title_fullStr | Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta‐Analysis |
| title_full_unstemmed | Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta‐Analysis |
| title_short | Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta‐Analysis |
| title_sort | associations of cerebrovascular regulation and arterial stiffness with cerebral small vessel disease a systematic review and meta analysis |
| topic | arterial stiffness cerebral autoregulation cerebral small vessel disease cerebrovascular reactivity |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.123.032616 |
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