THE DRUG-INDUCED HEPATITIS IN CHILDREN
Among toxic lesions of the liver, an important place belongs to medicinal hepatitis. Among patients with hepatitis, drug disease of the liver occurs in 0.7—1.4% of cases, and in the presence of jaundice — in 5%. A family case of sisters 9 and 4-year-old life development of acute drug hepatitis caus...
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| Format: | Article |
| Language: | Russian |
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LLC "Diagnostics and Vaccines"
2017-03-01
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| Series: | Детские инфекции (Москва) |
| Subjects: | |
| Online Access: | https://detinf.elpub.ru/jour/article/view/277 |
| _version_ | 1797881760642498560 |
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| author | O. V. Molochkova O. B. Kovalev V. F. Uchaykin V. A. Konev Yu. S. Snetkova |
| author_facet | O. V. Molochkova O. B. Kovalev V. F. Uchaykin V. A. Konev Yu. S. Snetkova |
| author_sort | O. V. Molochkova |
| collection | DOAJ |
| description | Among toxic lesions of the liver, an important place belongs to medicinal hepatitis. Among patients with hepatitis, drug disease of the liver occurs in 0.7—1.4% of cases, and in the presence of jaundice — in 5%. A family case of sisters 9 and 4-year-old life development of acute drug hepatitis caused by ibuprofen in a daily dose of 32 mg / kg (total 3.2 g) and 25 mg / kg (total 2 g), respectively, was demonstrated in siblings. Hepatitis developed after an acute respiratory infection. Weakness, nausea, vomiting, jaundice of the skin and sclera, pruritus, multiple increase in serum transaminases and markers of cholestasis are revealed. Viral hepatitis and some hereditary liver diseases were excluded. The drug lesion of the liver was of a mixed nature: hepatocellular (cytotoxic) and cholestatic. Timely administration of therapy (detoxification, glucocorticosteroids, ursodeoxycholic acid (Ursosan) led to a regression of clinical symptoms of the disease and positive dynamics of laboratory indicators. |
| first_indexed | 2024-04-10T03:25:21Z |
| format | Article |
| id | doaj.art-459f959d35514563b091a2936c446738 |
| institution | Directory Open Access Journal |
| issn | 2072-8107 |
| language | Russian |
| last_indexed | 2024-04-10T03:25:21Z |
| publishDate | 2017-03-01 |
| publisher | LLC "Diagnostics and Vaccines" |
| record_format | Article |
| series | Детские инфекции (Москва) |
| spelling | doaj.art-459f959d35514563b091a2936c4467382023-03-13T07:28:24ZrusLLC "Diagnostics and Vaccines"Детские инфекции (Москва)2072-81072017-03-01161425110.22627/2072-8107-2017-16-1-42-51270THE DRUG-INDUCED HEPATITIS IN CHILDRENO. V. Molochkova0O. B. Kovalev1V. F. Uchaykin2V. A. Konev3Yu. S. Snetkova4Российский национальный исследовательский медицинский университет имени Н. И. ПироговаРоссийский национальный исследовательский медицинский университет имени Н. И. Пирогова; Детская городская клиническая больница №9 имени Г. Н. СперанскогоРоссийский национальный исследовательский медицинский университет имени Н. И. ПироговаРоссийский национальный исследовательский медицинский университет имени Н. И. ПироговаДетская городская клиническая больница №9 имени Г. Н. СперанскогоAmong toxic lesions of the liver, an important place belongs to medicinal hepatitis. Among patients with hepatitis, drug disease of the liver occurs in 0.7—1.4% of cases, and in the presence of jaundice — in 5%. A family case of sisters 9 and 4-year-old life development of acute drug hepatitis caused by ibuprofen in a daily dose of 32 mg / kg (total 3.2 g) and 25 mg / kg (total 2 g), respectively, was demonstrated in siblings. Hepatitis developed after an acute respiratory infection. Weakness, nausea, vomiting, jaundice of the skin and sclera, pruritus, multiple increase in serum transaminases and markers of cholestasis are revealed. Viral hepatitis and some hereditary liver diseases were excluded. The drug lesion of the liver was of a mixed nature: hepatocellular (cytotoxic) and cholestatic. Timely administration of therapy (detoxification, glucocorticosteroids, ursodeoxycholic acid (Ursosan) led to a regression of clinical symptoms of the disease and positive dynamics of laboratory indicators.https://detinf.elpub.ru/jour/article/view/277гепатотоксичностьлекарственный гепатитибупрофен (нурофен)детиурсодезоксихолевая кислотаурсосан |
| spellingShingle | O. V. Molochkova O. B. Kovalev V. F. Uchaykin V. A. Konev Yu. S. Snetkova THE DRUG-INDUCED HEPATITIS IN CHILDREN Детские инфекции (Москва) гепатотоксичность лекарственный гепатит ибупрофен (нурофен) дети урсодезоксихолевая кислота урсосан |
| title | THE DRUG-INDUCED HEPATITIS IN CHILDREN |
| title_full | THE DRUG-INDUCED HEPATITIS IN CHILDREN |
| title_fullStr | THE DRUG-INDUCED HEPATITIS IN CHILDREN |
| title_full_unstemmed | THE DRUG-INDUCED HEPATITIS IN CHILDREN |
| title_short | THE DRUG-INDUCED HEPATITIS IN CHILDREN |
| title_sort | drug induced hepatitis in children |
| topic | гепатотоксичность лекарственный гепатит ибупрофен (нурофен) дети урсодезоксихолевая кислота урсосан |
| url | https://detinf.elpub.ru/jour/article/view/277 |
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