Association between epicardial adipose tissue, high-sensitivity C-reactive protein and myocardial dysfunction in middle-aged men with suspected metabolic syndrome
Abstract Background As body fat composition and metabolism differ between men and women, we evaluated sex-related differences in the association among epicardial adipose tissue (EAT), secretome profile, and myocardial function of subjects with suspected metabolic syndrome. Methods We evaluated 277 p...
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| Format: | Article |
| Language: | English |
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BMC
2018-06-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12933-018-0735-7 |
| _version_ | 1819129984455802880 |
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| author | Dong-Hyuk Cho Hyung Joon Joo Mi-Na Kim Do-Sun Lim Wan Joo Shim Seong-Mi Park |
| author_facet | Dong-Hyuk Cho Hyung Joon Joo Mi-Na Kim Do-Sun Lim Wan Joo Shim Seong-Mi Park |
| author_sort | Dong-Hyuk Cho |
| collection | DOAJ |
| description | Abstract Background As body fat composition and metabolism differ between men and women, we evaluated sex-related differences in the association among epicardial adipose tissue (EAT), secretome profile, and myocardial function of subjects with suspected metabolic syndrome. Methods We evaluated 277 participants (men, n = 140; 56.1 ± 4.7 years) who underwent conventional echocardiography and two-dimensional speckle tracking from the Seoul Metabolic Syndrome cohort. EAT was measured from the right ventricular free wall perpendicular to the aortic annulus at end systole. Global longitudinal strain (GLS) was obtained from 18 apical segments. Apolipoprotein A1, apolipoprotein B, adiponectin, and high-sensitivity C-reactive protein (hs-CRP) levels were measured using immunoturbidimetry assay. Results Mean age, body mass index, and hs-CRP level did not differ by sex. Waist circumference, fasting blood glucose level, and triglyceride/high-density lipoprotein cholesterol ratio were higher, and apolipoprotein AI and adiponectin levels were lower in men. No significant difference in mean EAT thickness was found (7.02 ± 1.81 vs. 7.13 ± 1.70 mm, p = 0.613). Men had a higher left ventricular (LV) mass index and lower GLS. EAT thickness was associated with hs-CRP level in men alone (ß = 0.206, p = 0.015). LV mass index (ß = 2.311, p = 0.037) and function represented by e′ (ß = − 0.279, p = 0.001) and GLS (ß = − 0.332, p < 0.001) were independently associated with EAT thickness in men alone. Conclusions In middle-aged subjects with suspected metabolic syndrome, EAT was associated with inflammation represented by hs-CRP level, LV mass, and subclinical myocardial dysfunction only in men, suggesting that the inflammatory activity of EAT induced myocardial remodeling and dysfunction in middle-aged subjects but was attenuated in women. Trial registration NCT02077530 (date of registration: November 1, 2013) |
| first_indexed | 2024-12-22T08:52:24Z |
| format | Article |
| id | doaj.art-45a024dfbb4d41c9a604f176d8129c8d |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-22T08:52:24Z |
| publishDate | 2018-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-45a024dfbb4d41c9a604f176d8129c8d2022-12-21T18:31:56ZengBMCCardiovascular Diabetology1475-28402018-06-011711910.1186/s12933-018-0735-7Association between epicardial adipose tissue, high-sensitivity C-reactive protein and myocardial dysfunction in middle-aged men with suspected metabolic syndromeDong-Hyuk Cho0Hyung Joon Joo1Mi-Na Kim2Do-Sun Lim3Wan Joo Shim4Seong-Mi Park5Division of Cardiology, Korea University College of Medicine, Anam HospitalDivision of Cardiology, Korea University College of Medicine, Anam HospitalDivision of Cardiology, Korea University College of Medicine, Anam HospitalDivision of Cardiology, Korea University College of Medicine, Anam HospitalDivision of Cardiology, Korea University College of Medicine, Anam HospitalDivision of Cardiology, Korea University College of Medicine, Anam HospitalAbstract Background As body fat composition and metabolism differ between men and women, we evaluated sex-related differences in the association among epicardial adipose tissue (EAT), secretome profile, and myocardial function of subjects with suspected metabolic syndrome. Methods We evaluated 277 participants (men, n = 140; 56.1 ± 4.7 years) who underwent conventional echocardiography and two-dimensional speckle tracking from the Seoul Metabolic Syndrome cohort. EAT was measured from the right ventricular free wall perpendicular to the aortic annulus at end systole. Global longitudinal strain (GLS) was obtained from 18 apical segments. Apolipoprotein A1, apolipoprotein B, adiponectin, and high-sensitivity C-reactive protein (hs-CRP) levels were measured using immunoturbidimetry assay. Results Mean age, body mass index, and hs-CRP level did not differ by sex. Waist circumference, fasting blood glucose level, and triglyceride/high-density lipoprotein cholesterol ratio were higher, and apolipoprotein AI and adiponectin levels were lower in men. No significant difference in mean EAT thickness was found (7.02 ± 1.81 vs. 7.13 ± 1.70 mm, p = 0.613). Men had a higher left ventricular (LV) mass index and lower GLS. EAT thickness was associated with hs-CRP level in men alone (ß = 0.206, p = 0.015). LV mass index (ß = 2.311, p = 0.037) and function represented by e′ (ß = − 0.279, p = 0.001) and GLS (ß = − 0.332, p < 0.001) were independently associated with EAT thickness in men alone. Conclusions In middle-aged subjects with suspected metabolic syndrome, EAT was associated with inflammation represented by hs-CRP level, LV mass, and subclinical myocardial dysfunction only in men, suggesting that the inflammatory activity of EAT induced myocardial remodeling and dysfunction in middle-aged subjects but was attenuated in women. Trial registration NCT02077530 (date of registration: November 1, 2013)http://link.springer.com/article/10.1186/s12933-018-0735-7Epicardial adipose tissueSexGlobal longitudinal strainHigh-sensitivity C-reactive proteinMetabolic syndrome |
| spellingShingle | Dong-Hyuk Cho Hyung Joon Joo Mi-Na Kim Do-Sun Lim Wan Joo Shim Seong-Mi Park Association between epicardial adipose tissue, high-sensitivity C-reactive protein and myocardial dysfunction in middle-aged men with suspected metabolic syndrome Cardiovascular Diabetology Epicardial adipose tissue Sex Global longitudinal strain High-sensitivity C-reactive protein Metabolic syndrome |
| title | Association between epicardial adipose tissue, high-sensitivity C-reactive protein and myocardial dysfunction in middle-aged men with suspected metabolic syndrome |
| title_full | Association between epicardial adipose tissue, high-sensitivity C-reactive protein and myocardial dysfunction in middle-aged men with suspected metabolic syndrome |
| title_fullStr | Association between epicardial adipose tissue, high-sensitivity C-reactive protein and myocardial dysfunction in middle-aged men with suspected metabolic syndrome |
| title_full_unstemmed | Association between epicardial adipose tissue, high-sensitivity C-reactive protein and myocardial dysfunction in middle-aged men with suspected metabolic syndrome |
| title_short | Association between epicardial adipose tissue, high-sensitivity C-reactive protein and myocardial dysfunction in middle-aged men with suspected metabolic syndrome |
| title_sort | association between epicardial adipose tissue high sensitivity c reactive protein and myocardial dysfunction in middle aged men with suspected metabolic syndrome |
| topic | Epicardial adipose tissue Sex Global longitudinal strain High-sensitivity C-reactive protein Metabolic syndrome |
| url | http://link.springer.com/article/10.1186/s12933-018-0735-7 |
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