Epidemiology of early esophageal adenocarcinoma
Background/Aims Endoscopic resection has become the preferred treatment approach for select early esophageal adenocarcinoma (EAC); however, the epidemiology of early stage disease has not been well defined. Methods Surveillance Epidemiology and End Results (SEER) data were analyzed to determine age-...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Society of Gastrointestinal Endoscopy
2022-05-01
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| Series: | Clinical Endoscopy |
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| Online Access: | http://www.e-ce.org/upload/pdf/ce-2021-152.pdf |
| _version_ | 1827613792978075648 |
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| author | Thuy-Van P. Hang Zachary Spiritos Anthony M. Gamboa Zhengjia Chen Seth Force Vaishali Patel Saurabh Chawla Steven Keilin Nabil F. Saba Bassel El-Rayes Qiang Cai Field F. Willingham |
| author_facet | Thuy-Van P. Hang Zachary Spiritos Anthony M. Gamboa Zhengjia Chen Seth Force Vaishali Patel Saurabh Chawla Steven Keilin Nabil F. Saba Bassel El-Rayes Qiang Cai Field F. Willingham |
| author_sort | Thuy-Van P. Hang |
| collection | DOAJ |
| description | Background/Aims Endoscopic resection has become the preferred treatment approach for select early esophageal adenocarcinoma (EAC); however, the epidemiology of early stage disease has not been well defined. Methods Surveillance Epidemiology and End Results (SEER) data were analyzed to determine age-adjusted incidence rates among major epithelial carcinomas, including EAC, from 1973 to 2017. The percent change in incidence over time was compared according to tumor subtype. Early T-stage, node-negative EAC without metastasis was examined from 2004 to 2017 when precise T-stage data were available. Results The percent change in annual incidence from 1973 to 2017 was 767% for EAC. Joinpoint analysis showed that the average annual percent change in EAC from 1973 to 2017 was 5.11% (95% confidence interval, 4.66%–5.56%). The annual percent change appeared to plateau between 2004 and 2017; however, early EAC decreased from 2010 to 2017, with an annual percent change of –5.78%. Conclusions There has been a 7-fold increase in the incidence of EAC, which was significantly greater than that of the other major epithelial malignancies examined. More recently, the incidence of early EAC has been decreasing. Approximately one in five patients has node negative, potentially resectable early stage disease. |
| first_indexed | 2024-03-09T08:45:42Z |
| format | Article |
| id | doaj.art-45a192716d3a46b49ed640115c58e5ee |
| institution | Directory Open Access Journal |
| issn | 2234-2400 2234-2443 |
| language | English |
| last_indexed | 2024-03-09T08:45:42Z |
| publishDate | 2022-05-01 |
| publisher | Korean Society of Gastrointestinal Endoscopy |
| record_format | Article |
| series | Clinical Endoscopy |
| spelling | doaj.art-45a192716d3a46b49ed640115c58e5ee2023-12-02T15:30:56ZengKorean Society of Gastrointestinal EndoscopyClinical Endoscopy2234-24002234-24432022-05-0155337238010.5946/ce.2021.1527617Epidemiology of early esophageal adenocarcinomaThuy-Van P. Hang0Zachary Spiritos1Anthony M. Gamboa2Zhengjia Chen3Seth Force4Vaishali Patel5Saurabh Chawla6Steven Keilin7Nabil F. Saba8Bassel El-Rayes9Qiang Cai10Field F. Willingham11 Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, GA, USA Department of Medicine, Division of Gastroenterology, Duke University, Durham, NC, USA Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University, Nashville, TN, USA Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA Department of Surgery, Division of Cardiothoracic Surgery, Emory University, Atlanta, GA, USA Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, GA, USA Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, GA, USA Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, GA, USA Emory Winship Cancer Institute, Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA Emory Winship Cancer Institute, Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, GA, USA Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, GA, USABackground/Aims Endoscopic resection has become the preferred treatment approach for select early esophageal adenocarcinoma (EAC); however, the epidemiology of early stage disease has not been well defined. Methods Surveillance Epidemiology and End Results (SEER) data were analyzed to determine age-adjusted incidence rates among major epithelial carcinomas, including EAC, from 1973 to 2017. The percent change in incidence over time was compared according to tumor subtype. Early T-stage, node-negative EAC without metastasis was examined from 2004 to 2017 when precise T-stage data were available. Results The percent change in annual incidence from 1973 to 2017 was 767% for EAC. Joinpoint analysis showed that the average annual percent change in EAC from 1973 to 2017 was 5.11% (95% confidence interval, 4.66%–5.56%). The annual percent change appeared to plateau between 2004 and 2017; however, early EAC decreased from 2010 to 2017, with an annual percent change of –5.78%. Conclusions There has been a 7-fold increase in the incidence of EAC, which was significantly greater than that of the other major epithelial malignancies examined. More recently, the incidence of early EAC has been decreasing. Approximately one in five patients has node negative, potentially resectable early stage disease.http://www.e-ce.org/upload/pdf/ce-2021-152.pdfadenocarcinomabarrett’s esophagusepidemiologyesophageal neoplasm |
| spellingShingle | Thuy-Van P. Hang Zachary Spiritos Anthony M. Gamboa Zhengjia Chen Seth Force Vaishali Patel Saurabh Chawla Steven Keilin Nabil F. Saba Bassel El-Rayes Qiang Cai Field F. Willingham Epidemiology of early esophageal adenocarcinoma Clinical Endoscopy adenocarcinoma barrett’s esophagus epidemiology esophageal neoplasm |
| title | Epidemiology of early esophageal adenocarcinoma |
| title_full | Epidemiology of early esophageal adenocarcinoma |
| title_fullStr | Epidemiology of early esophageal adenocarcinoma |
| title_full_unstemmed | Epidemiology of early esophageal adenocarcinoma |
| title_short | Epidemiology of early esophageal adenocarcinoma |
| title_sort | epidemiology of early esophageal adenocarcinoma |
| topic | adenocarcinoma barrett’s esophagus epidemiology esophageal neoplasm |
| url | http://www.e-ce.org/upload/pdf/ce-2021-152.pdf |
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