Insight into the Role of Angiopoietins in Ageing-Associated Diseases
Angiopoietin (Ang) and its receptor, TIE signaling, contribute to the development and maturation of embryonic vasculature as well as vascular remodeling and permeability in adult tissues. Targeting both this signaling pathway and the major pathway with vascular endothelial growth factor (VEGF) is ex...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/12/2636 |
| _version_ | 1827700534569598976 |
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| author | Shin-ichiro Hayashi Hiromi Rakugi Ryuichi Morishita |
| author_facet | Shin-ichiro Hayashi Hiromi Rakugi Ryuichi Morishita |
| author_sort | Shin-ichiro Hayashi |
| collection | DOAJ |
| description | Angiopoietin (Ang) and its receptor, TIE signaling, contribute to the development and maturation of embryonic vasculature as well as vascular remodeling and permeability in adult tissues. Targeting both this signaling pathway and the major pathway with vascular endothelial growth factor (VEGF) is expected to permit clinical applications, especially in antiangiogenic therapies against tumors. Several drugs targeting the Ang-TIE signaling pathway in cancer patients are under clinical development. Similar to how cancer increases with age, unsuitable angiogenesis or endothelial dysfunction is often seen in other ageing-associated diseases (AADs) such as atherosclerosis, Alzheimer’s disease, type 2 diabetes, chronic kidney disease and cardiovascular diseases. Thus, the Ang-TIE pathway is a possible molecular target for AAD therapy. In this review, we focus on the potential role of the Ang-TIE signaling pathway in AADs, especially non-cancer-related AADs. We also suggest translational insights and future clinical applications of this pathway in those AADs. |
| first_indexed | 2024-03-10T14:14:28Z |
| format | Article |
| id | doaj.art-45a41f9a522044d9836142ccb2ce0d8b |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T14:14:28Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-45a41f9a522044d9836142ccb2ce0d8b2023-11-20T23:52:26ZengMDPI AGCells2073-44092020-12-01912263610.3390/cells9122636Insight into the Role of Angiopoietins in Ageing-Associated DiseasesShin-ichiro Hayashi0Hiromi Rakugi1Ryuichi Morishita2Department of Clinical Gene Therapy, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, JapanDepartment of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, JapanDepartment of Clinical Gene Therapy, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, JapanAngiopoietin (Ang) and its receptor, TIE signaling, contribute to the development and maturation of embryonic vasculature as well as vascular remodeling and permeability in adult tissues. Targeting both this signaling pathway and the major pathway with vascular endothelial growth factor (VEGF) is expected to permit clinical applications, especially in antiangiogenic therapies against tumors. Several drugs targeting the Ang-TIE signaling pathway in cancer patients are under clinical development. Similar to how cancer increases with age, unsuitable angiogenesis or endothelial dysfunction is often seen in other ageing-associated diseases (AADs) such as atherosclerosis, Alzheimer’s disease, type 2 diabetes, chronic kidney disease and cardiovascular diseases. Thus, the Ang-TIE pathway is a possible molecular target for AAD therapy. In this review, we focus on the potential role of the Ang-TIE signaling pathway in AADs, especially non-cancer-related AADs. We also suggest translational insights and future clinical applications of this pathway in those AADs.https://www.mdpi.com/2073-4409/9/12/2636angiopoietinageingageing-associated diseasesendothelial cellsvascular function |
| spellingShingle | Shin-ichiro Hayashi Hiromi Rakugi Ryuichi Morishita Insight into the Role of Angiopoietins in Ageing-Associated Diseases Cells angiopoietin ageing ageing-associated diseases endothelial cells vascular function |
| title | Insight into the Role of Angiopoietins in Ageing-Associated Diseases |
| title_full | Insight into the Role of Angiopoietins in Ageing-Associated Diseases |
| title_fullStr | Insight into the Role of Angiopoietins in Ageing-Associated Diseases |
| title_full_unstemmed | Insight into the Role of Angiopoietins in Ageing-Associated Diseases |
| title_short | Insight into the Role of Angiopoietins in Ageing-Associated Diseases |
| title_sort | insight into the role of angiopoietins in ageing associated diseases |
| topic | angiopoietin ageing ageing-associated diseases endothelial cells vascular function |
| url | https://www.mdpi.com/2073-4409/9/12/2636 |
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