| Summary: | Introduction: Due to the well-known
relationship between inflammatory processes and carcinogenesis, the diagnostic
and prognostic value of systemic inflammatory markers are at the focus of
research. This study aimed to investigate the predictive value of inflammatory
cell data obtained from complete blood count in incidentally detected thyroid
papillary carcinoma.
Methods: A total of 100 cases were
included in the study, consisting of histopathologically diagnosed multinodular
hyperplasia (MNH) (N = 20), lymphocytic thyroiditis (LT) (n = 20), incidental
thyroid papillary carcinoma (ITPC) (n = 20), incidental papillary carcinoma and
lymphocytic thyroiditis (ITPCLT) (n = 20), and thyroid papillary carcinoma
(TPC) (n = 20). Neutrophil / lymphocyte ratio (NLR), platelet/ lymphocyte ratio
(PLR), platelet/neutrophil ratio (PNR), lymphocyte/ monocyte ratio (LMR) and
lymphocyte/ eosinophil ratio (LER) values were compared between the groups.
Results: No significant difference
was detected between the groups concerning the mean inflammatory cell and
platelet values. However, statistical significance was observed between the
ITPC and ITPCLT groups regarding the mean LMR and LER values (p=0.009 and
p=0.037, respectively). Higher LMR was found in the ITPC group, while higher
LER was seen in the ITPCLT group.
Conclusions: We suggest that besides
ratios such as NLR and PLR used as systemic inflammatory markers in carcinogenetic
processes, the evaluation of LER and LMR might be imperative as well.
Therefore, these potential markers should be studied in bigger series of
tumors, especially where inflammatory processes are involved in the etiology.
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