Urinary Metabolic Biomarker Profiling for Cancer Diagnosis by Terahertz Spectroscopy: Review and Perspective
In the last decade, terahertz (THz) technologies have been introduced to the detection, identification, and quantification of biomolecules in various biological samples. This review focuses on substances that represent important biomarkers in the urine associated with various cancers and their treat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Photonics |
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| Online Access: | https://www.mdpi.com/2304-6732/10/9/1051 |
| _version_ | 1797577802644455424 |
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| author | Andreja Abina Tjaša Korošec Uroš Puc Mojca Jazbinšek Aleksander Zidanšek |
| author_facet | Andreja Abina Tjaša Korošec Uroš Puc Mojca Jazbinšek Aleksander Zidanšek |
| author_sort | Andreja Abina |
| collection | DOAJ |
| description | In the last decade, terahertz (THz) technologies have been introduced to the detection, identification, and quantification of biomolecules in various biological samples. This review focuses on substances that represent important biomarkers in the urine associated with various cancers and their treatments. From a diagnostic point of view, urine liquid biopsy is particularly important because it allows the non-invasive and rapid collection of large volumes of samples. In this review, the THz spectral responses of substances considered metabolic biomarkers in urine and obtained in previous studies are collected. In addition, the findings from the relatively small number of prior studies that have already been carried out on urine samples are summarised. In this context, we also present the different THz methods used for urine analysis. Finally, a brief discussion is given, presenting perspectives for future research in this field, interpreted based on the results of previous studies. This work provides important information on the further application of THz techniques in biomedicine for detecting and monitoring urinary biomarkers for various diseases, including cancer. |
| first_indexed | 2024-03-10T22:14:09Z |
| format | Article |
| id | doaj.art-45a5b062268a4d52995e973286e3c956 |
| institution | Directory Open Access Journal |
| issn | 2304-6732 |
| language | English |
| last_indexed | 2024-03-10T22:14:09Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Photonics |
| spelling | doaj.art-45a5b062268a4d52995e973286e3c9562023-11-19T12:30:23ZengMDPI AGPhotonics2304-67322023-09-01109105110.3390/photonics10091051Urinary Metabolic Biomarker Profiling for Cancer Diagnosis by Terahertz Spectroscopy: Review and PerspectiveAndreja Abina0Tjaša Korošec1Uroš Puc2Mojca Jazbinšek3Aleksander Zidanšek4Jožef Stefan International Postgraduate School, Jamova Cesta 39, SI-1000 Ljubljana, SloveniaJožef Stefan International Postgraduate School, Jamova Cesta 39, SI-1000 Ljubljana, SloveniaJožef Stefan International Postgraduate School, Jamova Cesta 39, SI-1000 Ljubljana, SloveniaInstitute of Computational Physics, Zurich University of Applied Sciences (ZHAW), Technikumstrasse 71, 8400 Winterthur, SwitzerlandJožef Stefan International Postgraduate School, Jamova Cesta 39, SI-1000 Ljubljana, SloveniaIn the last decade, terahertz (THz) technologies have been introduced to the detection, identification, and quantification of biomolecules in various biological samples. This review focuses on substances that represent important biomarkers in the urine associated with various cancers and their treatments. From a diagnostic point of view, urine liquid biopsy is particularly important because it allows the non-invasive and rapid collection of large volumes of samples. In this review, the THz spectral responses of substances considered metabolic biomarkers in urine and obtained in previous studies are collected. In addition, the findings from the relatively small number of prior studies that have already been carried out on urine samples are summarised. In this context, we also present the different THz methods used for urine analysis. Finally, a brief discussion is given, presenting perspectives for future research in this field, interpreted based on the results of previous studies. This work provides important information on the further application of THz techniques in biomedicine for detecting and monitoring urinary biomarkers for various diseases, including cancer.https://www.mdpi.com/2304-6732/10/9/1051terahertz spectroscopyurinary biomarkersmetabolic biomarkerscancer diagnosticsbiomoleculesnon-invasive detection |
| spellingShingle | Andreja Abina Tjaša Korošec Uroš Puc Mojca Jazbinšek Aleksander Zidanšek Urinary Metabolic Biomarker Profiling for Cancer Diagnosis by Terahertz Spectroscopy: Review and Perspective Photonics terahertz spectroscopy urinary biomarkers metabolic biomarkers cancer diagnostics biomolecules non-invasive detection |
| title | Urinary Metabolic Biomarker Profiling for Cancer Diagnosis by Terahertz Spectroscopy: Review and Perspective |
| title_full | Urinary Metabolic Biomarker Profiling for Cancer Diagnosis by Terahertz Spectroscopy: Review and Perspective |
| title_fullStr | Urinary Metabolic Biomarker Profiling for Cancer Diagnosis by Terahertz Spectroscopy: Review and Perspective |
| title_full_unstemmed | Urinary Metabolic Biomarker Profiling for Cancer Diagnosis by Terahertz Spectroscopy: Review and Perspective |
| title_short | Urinary Metabolic Biomarker Profiling for Cancer Diagnosis by Terahertz Spectroscopy: Review and Perspective |
| title_sort | urinary metabolic biomarker profiling for cancer diagnosis by terahertz spectroscopy review and perspective |
| topic | terahertz spectroscopy urinary biomarkers metabolic biomarkers cancer diagnostics biomolecules non-invasive detection |
| url | https://www.mdpi.com/2304-6732/10/9/1051 |
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