COVID-19 rebound after oral treatment in a nursing home facility: A case series
Paxlovid (nirmatrevir/ritonavir) is a 2 drug regimen taken together twice daily for 5 days was authorized for emergency use for nonhospitalized patients who are at risk for the progression of coronavirus disease (COVID-19). However, recurrence of symptoms 2–8 days after completing the treatment cour...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
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| Series: | Infectious Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772431X22000521 |
| _version_ | 1797345844660273152 |
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| author | Alex P. Betrosian Stavros M. Christou Stavroula Kalathaki |
| author_facet | Alex P. Betrosian Stavros M. Christou Stavroula Kalathaki |
| author_sort | Alex P. Betrosian |
| collection | DOAJ |
| description | Paxlovid (nirmatrevir/ritonavir) is a 2 drug regimen taken together twice daily for 5 days was authorized for emergency use for nonhospitalized patients who are at risk for the progression of coronavirus disease (COVID-19). However, recurrence of symptoms 2–8 days after completing the treatment course has been recently recognized. In some cases patients tested negative on a direct SARS-CoV-2 viral test and then tested positive again (rebound COVID-19). The disease is mild and requires no additional antiviral treatment. Data are limited based on anecdotal case reports and few studies. According to the available data it is unclear if rebound symptoms are due to the drug treatment, drug resistance, re-infection or impaired immunity. |
| first_indexed | 2024-03-08T11:24:35Z |
| format | Article |
| id | doaj.art-45a654227eba4dc684692d26dbd97f7f |
| institution | Directory Open Access Journal |
| issn | 2772-431X |
| language | English |
| last_indexed | 2024-03-08T11:24:35Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Infectious Medicine |
| spelling | doaj.art-45a654227eba4dc684692d26dbd97f7f2024-01-26T05:36:07ZengElsevierInfectious Medicine2772-431X2022-12-0114285287COVID-19 rebound after oral treatment in a nursing home facility: A case seriesAlex P. Betrosian0Stavros M. Christou1Stavroula Kalathaki2Evgenidion Hospital, Athens University, Papadiamantopoulou 20, 11527 Athens, Greece; Kallisto Skilled Nursing Facility, Athens, Greece; Corresponding author.Kallisto Skilled Nursing Facility, Athens, GreeceKallisto Skilled Nursing Facility, Athens, GreecePaxlovid (nirmatrevir/ritonavir) is a 2 drug regimen taken together twice daily for 5 days was authorized for emergency use for nonhospitalized patients who are at risk for the progression of coronavirus disease (COVID-19). However, recurrence of symptoms 2–8 days after completing the treatment course has been recently recognized. In some cases patients tested negative on a direct SARS-CoV-2 viral test and then tested positive again (rebound COVID-19). The disease is mild and requires no additional antiviral treatment. Data are limited based on anecdotal case reports and few studies. According to the available data it is unclear if rebound symptoms are due to the drug treatment, drug resistance, re-infection or impaired immunity.http://www.sciencedirect.com/science/article/pii/S2772431X22000521COVID-19InfectionPaxlovidNursing facility |
| spellingShingle | Alex P. Betrosian Stavros M. Christou Stavroula Kalathaki COVID-19 rebound after oral treatment in a nursing home facility: A case series Infectious Medicine COVID-19 Infection Paxlovid Nursing facility |
| title | COVID-19 rebound after oral treatment in a nursing home facility: A case series |
| title_full | COVID-19 rebound after oral treatment in a nursing home facility: A case series |
| title_fullStr | COVID-19 rebound after oral treatment in a nursing home facility: A case series |
| title_full_unstemmed | COVID-19 rebound after oral treatment in a nursing home facility: A case series |
| title_short | COVID-19 rebound after oral treatment in a nursing home facility: A case series |
| title_sort | covid 19 rebound after oral treatment in a nursing home facility a case series |
| topic | COVID-19 Infection Paxlovid Nursing facility |
| url | http://www.sciencedirect.com/science/article/pii/S2772431X22000521 |
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