Common variants in genes related to lipid and energy metabolism are associated with weight loss after an intervention in overweight/obese adolescents
Background: Some SNPs related to lipid and energy metabolism may be implicated not only in the development of obesity and associated comorbidities, but also in the weight loss response after a nutritional intervention. Objective: In this context, the present study analyzed four SNPs located within f...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Arán Ediciones, S. L.
2014-07-01
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| Series: | Nutrición Hospitalaria |
| Subjects: | |
| Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112014000800010&lng=en&tlng=en |
| _version_ | 1819105758467325952 |
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| author | Adriana Moleres Fermín I. Milagro Ascensión Marcos Eduardo González-Zorzano Cristina Campoy Jesús M. Garagorri M. Cristina Azcona-Sanjulian J. Alfredo Martinez Amelia Marti |
| author_facet | Adriana Moleres Fermín I. Milagro Ascensión Marcos Eduardo González-Zorzano Cristina Campoy Jesús M. Garagorri M. Cristina Azcona-Sanjulian J. Alfredo Martinez Amelia Marti |
| author_sort | Adriana Moleres |
| collection | DOAJ |
| description | Background: Some SNPs related to lipid and energy metabolism may be implicated not only in the development of obesity and associated comorbidities, but also in the weight loss response after a nutritional intervention. Objective: In this context, the present study analyzed four SNPs located within four genes known to be associated with obesity and other obesity-related complications, and their putative role in a weight-loss intervention in overweight/obese adolescents. Methods: The study population consisted of 199 overweight/obese adolescents (13-16 yr old) undergoing 10 weeks of a weight loss multidisciplinary intervention: the EVASYON programme (www.estudioevasyon.org). Adolescents were genotyped for 4 SNPs, and anthropometric measurements and biochemical markers were analyzed at the beginning and after the intervention. Results: Interestingly, APOA5(rs662799) was associated with the baseline anthropometric and biochemical outcomes, whereas FTO (rs9939609) seemed to be related with the change of these values after the 10-week intervention. The other two SNPs, located in the CETP (rs1800777) and the APOA1 (rs670) genes, showed important relationships with adiposity markers. Specifically, a combined model including both SNPs turned up to explain up to 24% of BMI-SDS change after 10 weeks of the multidisciplinary intervention, which may contribute to understand the weight loss response. Conclusion: Common variants in genes related to lipid and energy metabolism may influence not only biochemical outcomes but also weight loss response after a multidisciplinary intervention carried out in obese/overweight adolescents. |
| first_indexed | 2024-12-22T02:27:20Z |
| format | Article |
| id | doaj.art-45a6e3fa8bca4220b7744e6fd6f69cdc |
| institution | Directory Open Access Journal |
| issn | 0212-1611 |
| language | English |
| last_indexed | 2024-12-22T02:27:20Z |
| publishDate | 2014-07-01 |
| publisher | Arán Ediciones, S. L. |
| record_format | Article |
| series | Nutrición Hospitalaria |
| spelling | doaj.art-45a6e3fa8bca4220b7744e6fd6f69cdc2022-12-21T18:41:58ZengArán Ediciones, S. L.Nutrición Hospitalaria0212-16112014-07-01301758310.3305/nh.2014.30.1.7542S0212-16112014000800010Common variants in genes related to lipid and energy metabolism are associated with weight loss after an intervention in overweight/obese adolescentsAdriana Moleres0Fermín I. Milagro1Ascensión Marcos2Eduardo González-Zorzano3Cristina Campoy4Jesús M. Garagorri5M. Cristina Azcona-Sanjulian6J. Alfredo Martinez7Amelia Marti8University of NavarraUniversity of NavarraInstitute of Food Science.Technology and Nutrition (ICTAN)Cinfa LaboratoriesUniversidad de GranadaUniversidad de ZaragozaUniversity of Navarra HospitalUniversity of NavarraUniversity of NavarraBackground: Some SNPs related to lipid and energy metabolism may be implicated not only in the development of obesity and associated comorbidities, but also in the weight loss response after a nutritional intervention. Objective: In this context, the present study analyzed four SNPs located within four genes known to be associated with obesity and other obesity-related complications, and their putative role in a weight-loss intervention in overweight/obese adolescents. Methods: The study population consisted of 199 overweight/obese adolescents (13-16 yr old) undergoing 10 weeks of a weight loss multidisciplinary intervention: the EVASYON programme (www.estudioevasyon.org). Adolescents were genotyped for 4 SNPs, and anthropometric measurements and biochemical markers were analyzed at the beginning and after the intervention. Results: Interestingly, APOA5(rs662799) was associated with the baseline anthropometric and biochemical outcomes, whereas FTO (rs9939609) seemed to be related with the change of these values after the 10-week intervention. The other two SNPs, located in the CETP (rs1800777) and the APOA1 (rs670) genes, showed important relationships with adiposity markers. Specifically, a combined model including both SNPs turned up to explain up to 24% of BMI-SDS change after 10 weeks of the multidisciplinary intervention, which may contribute to understand the weight loss response. Conclusion: Common variants in genes related to lipid and energy metabolism may influence not only biochemical outcomes but also weight loss response after a multidisciplinary intervention carried out in obese/overweight adolescents.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112014000800010&lng=en&tlng=enAPOA1CETPEVASYONFTOAPOA5 |
| spellingShingle | Adriana Moleres Fermín I. Milagro Ascensión Marcos Eduardo González-Zorzano Cristina Campoy Jesús M. Garagorri M. Cristina Azcona-Sanjulian J. Alfredo Martinez Amelia Marti Common variants in genes related to lipid and energy metabolism are associated with weight loss after an intervention in overweight/obese adolescents Nutrición Hospitalaria APOA1 CETP EVASYON FTO APOA5 |
| title | Common variants in genes related to lipid and energy metabolism are associated with weight loss after an intervention in overweight/obese adolescents |
| title_full | Common variants in genes related to lipid and energy metabolism are associated with weight loss after an intervention in overweight/obese adolescents |
| title_fullStr | Common variants in genes related to lipid and energy metabolism are associated with weight loss after an intervention in overweight/obese adolescents |
| title_full_unstemmed | Common variants in genes related to lipid and energy metabolism are associated with weight loss after an intervention in overweight/obese adolescents |
| title_short | Common variants in genes related to lipid and energy metabolism are associated with weight loss after an intervention in overweight/obese adolescents |
| title_sort | common variants in genes related to lipid and energy metabolism are associated with weight loss after an intervention in overweight obese adolescents |
| topic | APOA1 CETP EVASYON FTO APOA5 |
| url | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112014000800010&lng=en&tlng=en |
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