High glucose, glucose fluctuation and carbonyl stress enhance brain microvascular endothelial barrier dysfunction: Implications for diabetic cerebral microvasculature

High glucose, glucose fluctuation and carbonyl stress enhance brain microvascular endothelial barrier dysfunction: Implications for diabetic cerebral microvasculature

We previously demonstrated that in normal glucose (5 mM), methylglyoxal (MG, a model of carbonyl stress) induced brain microvascular endothelial cell (IHEC) dysfunction that was associated with occludin glycation and prevented by N-acetylcysteine (NAC). Herein, we investigated the impact of high glu...

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Bibliographic Details
Main Authors:	Wei Li, Ronald E. Maloney, Tak Yee Aw
Format:	Article
Language:	English
Published:	Elsevier 2015-08-01
Series:	Redox Biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231715000312

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