Study on the influence of scaffold morphology and structure on osteogenic performance
The number of patients with bone defects caused by various bone diseases is increasing yearly in the aging population, and people are paying increasing attention to bone tissue engineering research. Currently, the application of bone tissue engineering mainly focuses on promoting fracture healing by...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1127162/full |
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| author | Jingyu Zhou Jingyu Zhou Jingyu Zhou Shilang Xiong Shilang Xiong Min Liu Min Liu Hao Yang Peng Wei Peng Wei Peng Wei Feng Yi Feng Yi Min Ouyang Min Ouyang Hanrui Xi Hanrui Xi Zhisheng Long Yayun Liu Jingtang Li Linghua Ding Long Xiong |
| author_facet | Jingyu Zhou Jingyu Zhou Jingyu Zhou Shilang Xiong Shilang Xiong Min Liu Min Liu Hao Yang Peng Wei Peng Wei Peng Wei Feng Yi Feng Yi Min Ouyang Min Ouyang Hanrui Xi Hanrui Xi Zhisheng Long Yayun Liu Jingtang Li Linghua Ding Long Xiong |
| author_sort | Jingyu Zhou |
| collection | DOAJ |
| description | The number of patients with bone defects caused by various bone diseases is increasing yearly in the aging population, and people are paying increasing attention to bone tissue engineering research. Currently, the application of bone tissue engineering mainly focuses on promoting fracture healing by carrying cytokines. However, cytokines implanted into the body easily cause an immune response, and the cost is high; therefore, the clinical treatment effect is not outstanding. In recent years, some scholars have proposed the concept of tissue-induced biomaterials that can induce bone regeneration through a scaffold structure without adding cytokines. By optimizing the scaffold structure, the performance of tissue-engineered bone scaffolds is improved and the osteogenesis effect is promoted, which provides ideas for the design and improvement of tissue-engineered bones in the future. In this study, the current understanding of the bone tissue structure is summarized through the discussion of current bone tissue engineering, and the current research on micro-nano bionic structure scaffolds and their osteogenesis mechanism is analyzed and discussed. |
| first_indexed | 2024-04-09T21:34:37Z |
| format | Article |
| id | doaj.art-45a82c64170443aaa5acbae059773b1d |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-09T21:34:37Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-45a82c64170443aaa5acbae059773b1d2023-03-27T04:34:25ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-03-011110.3389/fbioe.2023.11271621127162Study on the influence of scaffold morphology and structure on osteogenic performanceJingyu Zhou0Jingyu Zhou1Jingyu Zhou2Shilang Xiong3Shilang Xiong4Min Liu5Min Liu6Hao Yang7Peng Wei8Peng Wei9Peng Wei10Feng Yi11Feng Yi12Min Ouyang13Min Ouyang14Hanrui Xi15Hanrui Xi16Zhisheng Long17Yayun Liu18Jingtang Li19Linghua Ding20Long Xiong21Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaInstitute of Clinical Medicine, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, ChinaThe Second Clinical Medical College of Nanchang University, Nanchang, Jiangxi, ChinaInstitute of Clinical Medicine, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaThe Second Clinical Medical College of Nanchang University, Nanchang, Jiangxi, ChinaThe Second Clinical Medical College of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaInstitute of Clinical Medicine, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, ChinaThe Second Clinical Medical College of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaThe Second Clinical Medical College of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaThe Second Clinical Medical College of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaThe Second Clinical Medical College of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Orthopedics, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, ChinaDepartment of Traumatology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, ChinaDepartment of Traumatology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, ChinaDepartment of Orthopedics, Jinhua People’s Hospital, Jinhua, Zhejiang, ChinaDepartment of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaThe number of patients with bone defects caused by various bone diseases is increasing yearly in the aging population, and people are paying increasing attention to bone tissue engineering research. Currently, the application of bone tissue engineering mainly focuses on promoting fracture healing by carrying cytokines. However, cytokines implanted into the body easily cause an immune response, and the cost is high; therefore, the clinical treatment effect is not outstanding. In recent years, some scholars have proposed the concept of tissue-induced biomaterials that can induce bone regeneration through a scaffold structure without adding cytokines. By optimizing the scaffold structure, the performance of tissue-engineered bone scaffolds is improved and the osteogenesis effect is promoted, which provides ideas for the design and improvement of tissue-engineered bones in the future. In this study, the current understanding of the bone tissue structure is summarized through the discussion of current bone tissue engineering, and the current research on micro-nano bionic structure scaffolds and their osteogenesis mechanism is analyzed and discussed.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1127162/fullscaffoldnanotechnologyhierarchically structured scaffoldporositybone tissue regeneration |
| spellingShingle | Jingyu Zhou Jingyu Zhou Jingyu Zhou Shilang Xiong Shilang Xiong Min Liu Min Liu Hao Yang Peng Wei Peng Wei Peng Wei Feng Yi Feng Yi Min Ouyang Min Ouyang Hanrui Xi Hanrui Xi Zhisheng Long Yayun Liu Jingtang Li Linghua Ding Long Xiong Study on the influence of scaffold morphology and structure on osteogenic performance Frontiers in Bioengineering and Biotechnology scaffold nanotechnology hierarchically structured scaffold porosity bone tissue regeneration |
| title | Study on the influence of scaffold morphology and structure on osteogenic performance |
| title_full | Study on the influence of scaffold morphology and structure on osteogenic performance |
| title_fullStr | Study on the influence of scaffold morphology and structure on osteogenic performance |
| title_full_unstemmed | Study on the influence of scaffold morphology and structure on osteogenic performance |
| title_short | Study on the influence of scaffold morphology and structure on osteogenic performance |
| title_sort | study on the influence of scaffold morphology and structure on osteogenic performance |
| topic | scaffold nanotechnology hierarchically structured scaffold porosity bone tissue regeneration |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1127162/full |
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