Clinical biomarker discovery by SWATH-MS based label-free quantitative proteomics: impact of criteria for identification of differentiators and data normalization method

Clinical biomarker discovery by SWATH-MS based label-free quantitative proteomics: impact of criteria for identification of differentiators and data normalization method

Abstract Background SWATH-MS has emerged as the strategy of choice for biomarker discovery due to the proteome coverage achieved in acquisition and provision to re-interrogate the data. However, in quantitative analysis using SWATH, each sample from the comparison group is run individually in mass s...

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Bibliographic Details
Main Authors: Mythreyi Narasimhan, Sadhana Kannan, Aakash Chawade, Atanu Bhattacharjee, Rukmini Govekar
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Translational Medicine
Subjects:
Proteomic
LC–MS
SWATH
Normalization
p-value
Fold change
Online Access:http://link.springer.com/article/10.1186/s12967-019-1937-9

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