Inherited and Environmental Factors Influence Human Monocyte Heterogeneity
Blood monocytes develop in the bone marrow before being released into the peripheral circulation. The circulating monocyte pool is composed of multiple subsets, each with specialized functions. These cells are recruited to repopulate resident monocyte-derived cells in the periphery and also to sites...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.02581/full |
| _version_ | 1811214858260054016 |
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| author | Amit A. Patel Simon Yona |
| author_facet | Amit A. Patel Simon Yona |
| author_sort | Amit A. Patel |
| collection | DOAJ |
| description | Blood monocytes develop in the bone marrow before being released into the peripheral circulation. The circulating monocyte pool is composed of multiple subsets, each with specialized functions. These cells are recruited to repopulate resident monocyte-derived cells in the periphery and also to sites of injury. Several extrinsic factors influence the function and quantity of monocytes in the blood. Here, we outline the impact of sex, ethnicity, age, sleep, diet, and exercise on monocyte subsets and their function, highlighting that steady state is not a single physiological condition. A clearer understanding of the relationship between these factors and the immune system may allow for improved therapeutic strategies. |
| first_indexed | 2024-04-12T06:11:28Z |
| format | Article |
| id | doaj.art-45aa2dfcc3c94d79b0aa4733a5a60e7e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T06:11:28Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-45aa2dfcc3c94d79b0aa4733a5a60e7e2022-12-22T03:44:41ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-11-011010.3389/fimmu.2019.02581483845Inherited and Environmental Factors Influence Human Monocyte HeterogeneityAmit A. Patel0Simon Yona1Division of Medicine, University College London, University of London, London, United KingdomThe Institute of Dental Sciences, Hebrew University, Jerusalem, IsraelBlood monocytes develop in the bone marrow before being released into the peripheral circulation. The circulating monocyte pool is composed of multiple subsets, each with specialized functions. These cells are recruited to repopulate resident monocyte-derived cells in the periphery and also to sites of injury. Several extrinsic factors influence the function and quantity of monocytes in the blood. Here, we outline the impact of sex, ethnicity, age, sleep, diet, and exercise on monocyte subsets and their function, highlighting that steady state is not a single physiological condition. A clearer understanding of the relationship between these factors and the immune system may allow for improved therapeutic strategies.https://www.frontiersin.org/article/10.3389/fimmu.2019.02581/fullmonocytemacrophageinflammationsexagediet |
| spellingShingle | Amit A. Patel Simon Yona Inherited and Environmental Factors Influence Human Monocyte Heterogeneity Frontiers in Immunology monocyte macrophage inflammation sex age diet |
| title | Inherited and Environmental Factors Influence Human Monocyte Heterogeneity |
| title_full | Inherited and Environmental Factors Influence Human Monocyte Heterogeneity |
| title_fullStr | Inherited and Environmental Factors Influence Human Monocyte Heterogeneity |
| title_full_unstemmed | Inherited and Environmental Factors Influence Human Monocyte Heterogeneity |
| title_short | Inherited and Environmental Factors Influence Human Monocyte Heterogeneity |
| title_sort | inherited and environmental factors influence human monocyte heterogeneity |
| topic | monocyte macrophage inflammation sex age diet |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.02581/full |
| work_keys_str_mv | AT amitapatel inheritedandenvironmentalfactorsinfluencehumanmonocyteheterogeneity AT simonyona inheritedandenvironmentalfactorsinfluencehumanmonocyteheterogeneity |