Neuroinflammation in Multiple System Atrophy: Response to and Cause of alpha-Synuclein Aggregation
Multiple system atrophy (MSA) is a progressive neurodegenerative disease presenting with combinations of autonomic dysfunction, parkinsonism, cerebellar ataxia and/or pyramidal signs. Oligodendroglial cytoplasmic inclusions rich in α-synuclein (α-syn) constitute the disease hallmark, accompanied by...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-11-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00437/full |
| _version_ | 1818062575341928448 |
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| author | Bruno eDi Marco Vieira Rowan Andrew Warren Radford Roger S Chung Gilles J. Guillemin Dean Louis Pountney |
| author_facet | Bruno eDi Marco Vieira Rowan Andrew Warren Radford Roger S Chung Gilles J. Guillemin Dean Louis Pountney |
| author_sort | Bruno eDi Marco Vieira |
| collection | DOAJ |
| description | Multiple system atrophy (MSA) is a progressive neurodegenerative disease presenting with combinations of autonomic dysfunction, parkinsonism, cerebellar ataxia and/or pyramidal signs. Oligodendroglial cytoplasmic inclusions rich in α-synuclein (α-syn) constitute the disease hallmark, accompanied by neuronal loss and activation of glial cells which indicate neuroinflammation. Recent studies demonstrate that α-syn may be released from degenerating neurons to mediate formation of abnormal inclusion bodies and to induce neuroinflammation which, interestingly, might also favour the formation of intracellular α-syn aggregates as a consequence of cytokine release and the shift to a pro-inflammatory environment. Here we critically review the relationships between α-syn and astrocytic and microglial activation in MSA to explore the potential of therapeutics which target neuroinflammation. |
| first_indexed | 2024-12-10T14:06:23Z |
| format | Article |
| id | doaj.art-45ad8b3ec6cb430e9c2af67798985f9d |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-10T14:06:23Z |
| publishDate | 2015-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-45ad8b3ec6cb430e9c2af67798985f9d2022-12-22T01:45:39ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022015-11-01910.3389/fncel.2015.00437160564Neuroinflammation in Multiple System Atrophy: Response to and Cause of alpha-Synuclein AggregationBruno eDi Marco Vieira0Rowan Andrew Warren Radford1Roger S Chung2Gilles J. Guillemin3Dean Louis Pountney4Griffith UniversityMacquarie UniversityMacquarie UniversityMacquarie UniversityGriffith UniversityMultiple system atrophy (MSA) is a progressive neurodegenerative disease presenting with combinations of autonomic dysfunction, parkinsonism, cerebellar ataxia and/or pyramidal signs. Oligodendroglial cytoplasmic inclusions rich in α-synuclein (α-syn) constitute the disease hallmark, accompanied by neuronal loss and activation of glial cells which indicate neuroinflammation. Recent studies demonstrate that α-syn may be released from degenerating neurons to mediate formation of abnormal inclusion bodies and to induce neuroinflammation which, interestingly, might also favour the formation of intracellular α-syn aggregates as a consequence of cytokine release and the shift to a pro-inflammatory environment. Here we critically review the relationships between α-syn and astrocytic and microglial activation in MSA to explore the potential of therapeutics which target neuroinflammation.http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00437/fullMultiple System AtrophyNeuroinflammationAstrogliosisalpha-synuclienMicrogliosis |
| spellingShingle | Bruno eDi Marco Vieira Rowan Andrew Warren Radford Roger S Chung Gilles J. Guillemin Dean Louis Pountney Neuroinflammation in Multiple System Atrophy: Response to and Cause of alpha-Synuclein Aggregation Frontiers in Cellular Neuroscience Multiple System Atrophy Neuroinflammation Astrogliosis alpha-synuclien Microgliosis |
| title | Neuroinflammation in Multiple System Atrophy: Response to and Cause of alpha-Synuclein Aggregation |
| title_full | Neuroinflammation in Multiple System Atrophy: Response to and Cause of alpha-Synuclein Aggregation |
| title_fullStr | Neuroinflammation in Multiple System Atrophy: Response to and Cause of alpha-Synuclein Aggregation |
| title_full_unstemmed | Neuroinflammation in Multiple System Atrophy: Response to and Cause of alpha-Synuclein Aggregation |
| title_short | Neuroinflammation in Multiple System Atrophy: Response to and Cause of alpha-Synuclein Aggregation |
| title_sort | neuroinflammation in multiple system atrophy response to and cause of alpha synuclein aggregation |
| topic | Multiple System Atrophy Neuroinflammation Astrogliosis alpha-synuclien Microgliosis |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00437/full |
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