Ubiquitin protein E3 ligase ASB9 suppresses proliferation and promotes apoptosis in human spermatogonial stem cell line by inducing HIF1AN degradation

Ubiquitin protein E3 ligase ASB9 suppresses proliferation and promotes apoptosis in human spermatogonial stem cell line by inducing HIF1AN degradation

Abstract Background Spermatogonial stem cells (SSCs) are critical for sustaining spermatogenesis. Even though several regulators of SSC have been identified in rodents, the regulatory mechanism of SSC in humans has yet to be discovered. Methods To explore the regulatory mechanisms of human SSCs, we...

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Bibliographic Details
Main Authors: Ning Li, Qianyin Zhou, Zhang Yi, Huan Zhang, Dai Zhou
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Biological Research
Subjects:
Human
Testis
Spermatogonial stem cells
Proliferation
ASB9
HIF1AN
Online Access:https://doi.org/10.1186/s40659-023-00413-w

Internet

https://doi.org/10.1186/s40659-023-00413-w

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