Calculation of the Median Lethal Dose and Low Lethal Dose Using the CombiStats Biometric Software

Calculation of the Median Lethal Dose and Low Lethal Dose Using the CombiStats Biometric Software

The median lethal dose (LD50) and low lethal dose (LD10) are calculated in acute toxicity studies, as well as during specific activity assessment of some medicines. The aim of the study was to develop a procedure for using CombiStats to calculate LD50 and LD10. The authors proposed a step-by-step al...

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Bibliographic Details
Main Authors:	P. V. Shadrin, T. A. Batuashvili, L. V. Simutenko, N. P. Neugodova
Format:	Article
Language:	Russian
Published:	Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’) 2021-07-01
Series:	Регуляторные исследования и экспертиза лекарственных средств
Subjects:	median lethal dose ld<sub>50</sub> median effective dose ed<sub>50</sub> low lethal dose ld<sub>10</sub> combistats biometric software dose conversion medicinal products snake venom
Online Access:	https://www.vedomostincesmp.ru/jour/article/view/344

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