Precision installation of a highly efficient suicide gene safety switch in human induced pluripotent stem cells

Precision installation of a highly efficient suicide gene safety switch in human induced pluripotent stem cells

Abstract Human pluripotent stem cells, including induced pluripotent stem cells (iPSCs) and embryonic stem cells, hold great promise for cell‐based therapies, but safety concerns that complicate consideration for routine clinical use remain. Installing a “safety switch” based on the inducible caspas...

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Bibliographic Details
Main Authors: Zhong‐Dong Shi, Jason Tchao, Ling Wu, Aaron J. Carman
Format: Article
Language:English
Published: Oxford University Press 2020-11-01
Series:Stem Cells Translational Medicine
Subjects:
AAVS1 locus
CAG promoter
genome editing
genomic safe harbor
induced pluripotent stem cell
inducible caspase‐9
Online Access:https://doi.org/10.1002/sctm.20-0007

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