Endocannabinoids, Related Compounds and Their Metabolic Routes
Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors, the primary molecular targets responsible for the pharmacological effects of the Δ9-tetrahydrocannabinol. These bioactive lipids belong mainly to two classes of compounds: N-acylethanolamines and acylesters, bei...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-10-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/19/11/17078 |
| _version_ | 1818305063090651136 |
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| author | Filomena Fezza Monica Bari Rita Florio Emanuela Talamonti Monica Feole Mauro Maccarrone |
| author_facet | Filomena Fezza Monica Bari Rita Florio Emanuela Talamonti Monica Feole Mauro Maccarrone |
| author_sort | Filomena Fezza |
| collection | DOAJ |
| description | Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors, the primary molecular targets responsible for the pharmacological effects of the Δ9-tetrahydrocannabinol. These bioactive lipids belong mainly to two classes of compounds: N-acylethanolamines and acylesters, being N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG), respectively, their main representatives. During the last twenty years, an ever growing number of fatty acid derivatives (endocannabinoids and endocannabinoid-like compounds) have been discovered and their activities biological is the subject of intense investigations. Here, the most recent advances, from a therapeutic point of view, on endocannabinoids, related compounds, and their metabolic routes will be reviewed. |
| first_indexed | 2024-12-13T06:20:38Z |
| format | Article |
| id | doaj.art-45b0f917199b499f9fcfebaf4085c662 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-13T06:20:38Z |
| publishDate | 2014-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-45b0f917199b499f9fcfebaf4085c6622022-12-21T23:56:51ZengMDPI AGMolecules1420-30492014-10-011911170781710610.3390/molecules191117078molecules191117078Endocannabinoids, Related Compounds and Their Metabolic RoutesFilomena Fezza0Monica Bari1Rita Florio2Emanuela Talamonti3Monica Feole4Mauro Maccarrone5Department of Experimental Medicine & Surgery, Tor Vergata University of Rome, 00133 Rome, ItalyDepartment of Experimental Medicine & Surgery, Tor Vergata University of Rome, 00133 Rome, ItalyDepartment of Movement, Human and Health Sciences, Foro Italico University of Rome, 00128 Rome, ItalyEndocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli (NA), ItalyDepartment of Experimental Medicine & Surgery, Tor Vergata University of Rome, 00133 Rome, ItalyEuropean Center for Brain Research/IRCCS Santa Lucia Foundation, 00143 Rome, ItalyEndocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors, the primary molecular targets responsible for the pharmacological effects of the Δ9-tetrahydrocannabinol. These bioactive lipids belong mainly to two classes of compounds: N-acylethanolamines and acylesters, being N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG), respectively, their main representatives. During the last twenty years, an ever growing number of fatty acid derivatives (endocannabinoids and endocannabinoid-like compounds) have been discovered and their activities biological is the subject of intense investigations. Here, the most recent advances, from a therapeutic point of view, on endocannabinoids, related compounds, and their metabolic routes will be reviewed.http://www.mdpi.com/1420-3049/19/11/17078anandamide2-arachidonoylglycerolendocannabinoid metabolic routesfatty acids |
| spellingShingle | Filomena Fezza Monica Bari Rita Florio Emanuela Talamonti Monica Feole Mauro Maccarrone Endocannabinoids, Related Compounds and Their Metabolic Routes Molecules anandamide 2-arachidonoylglycerol endocannabinoid metabolic routes fatty acids |
| title | Endocannabinoids, Related Compounds and Their Metabolic Routes |
| title_full | Endocannabinoids, Related Compounds and Their Metabolic Routes |
| title_fullStr | Endocannabinoids, Related Compounds and Their Metabolic Routes |
| title_full_unstemmed | Endocannabinoids, Related Compounds and Their Metabolic Routes |
| title_short | Endocannabinoids, Related Compounds and Their Metabolic Routes |
| title_sort | endocannabinoids related compounds and their metabolic routes |
| topic | anandamide 2-arachidonoylglycerol endocannabinoid metabolic routes fatty acids |
| url | http://www.mdpi.com/1420-3049/19/11/17078 |
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