Interactions between extracellular vesicles and microbiome in human diseases: New therapeutic opportunities
Abstract In recent decades, accumulating research on the interactions between microbiome homeostasis and host health has broadened new frontiers in delineating the molecular mechanisms of disease pathogenesis and developing novel therapeutic strategies. By transporting proteins, nucleic acids, lipid...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-05-01
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| Series: | iMeta |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/imt2.86 |
| _version_ | 1826945135245524992 |
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| author | Rongjin Luo Yanmin Chang Huaizhen Liang Weifeng Zhang Yu Song Gaocai Li Cao Yang |
| author_facet | Rongjin Luo Yanmin Chang Huaizhen Liang Weifeng Zhang Yu Song Gaocai Li Cao Yang |
| author_sort | Rongjin Luo |
| collection | DOAJ |
| description | Abstract In recent decades, accumulating research on the interactions between microbiome homeostasis and host health has broadened new frontiers in delineating the molecular mechanisms of disease pathogenesis and developing novel therapeutic strategies. By transporting proteins, nucleic acids, lipids, and metabolites in their versatile bioactive molecules, extracellular vesicles (EVs), natural bioactive cell‐secreted nanoparticles, may be key mediators of microbiota–host communications. In addition to their positive and negative roles in diverse physiological and pathological processes, there is considerable evidence to implicate EVs secreted by bacteria (bacterial EVs [BEVs]) in the onset and progression of various diseases, including gastrointestinal, respiratory, dermatological, neurological, and musculoskeletal diseases, as well as in cancer. Moreover, an increasing number of studies have explored BEV‐based platforms to design novel biomedical diagnostic and therapeutic strategies. Hence, in this review, we highlight the recent advances in BEV biogenesis, composition, biofunctions, and their potential involvement in disease pathologies. Furthermore, we introduce the current and emerging clinical applications of BEVs in diagnostic analytics, vaccine design, and novel therapeutic development. |
| first_indexed | 2024-03-13T10:52:05Z |
| format | Article |
| id | doaj.art-45b1e904449a4721a37c9a6a56318f1a |
| institution | Directory Open Access Journal |
| issn | 2770-596X |
| language | English |
| last_indexed | 2025-02-17T20:50:00Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | iMeta |
| spelling | doaj.art-45b1e904449a4721a37c9a6a56318f1a2024-12-09T07:45:59ZengWileyiMeta2770-596X2023-05-0122n/an/a10.1002/imt2.86Interactions between extracellular vesicles and microbiome in human diseases: New therapeutic opportunitiesRongjin Luo0Yanmin Chang1Huaizhen Liang2Weifeng Zhang3Yu Song4Gaocai Li5Cao Yang6Department of Orthopaedics, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Neurology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Orthopaedics, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Orthopaedics, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Orthopaedics, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Orthopaedics, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Orthopaedics, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaAbstract In recent decades, accumulating research on the interactions between microbiome homeostasis and host health has broadened new frontiers in delineating the molecular mechanisms of disease pathogenesis and developing novel therapeutic strategies. By transporting proteins, nucleic acids, lipids, and metabolites in their versatile bioactive molecules, extracellular vesicles (EVs), natural bioactive cell‐secreted nanoparticles, may be key mediators of microbiota–host communications. In addition to their positive and negative roles in diverse physiological and pathological processes, there is considerable evidence to implicate EVs secreted by bacteria (bacterial EVs [BEVs]) in the onset and progression of various diseases, including gastrointestinal, respiratory, dermatological, neurological, and musculoskeletal diseases, as well as in cancer. Moreover, an increasing number of studies have explored BEV‐based platforms to design novel biomedical diagnostic and therapeutic strategies. Hence, in this review, we highlight the recent advances in BEV biogenesis, composition, biofunctions, and their potential involvement in disease pathologies. Furthermore, we introduce the current and emerging clinical applications of BEVs in diagnostic analytics, vaccine design, and novel therapeutic development.https://doi.org/10.1002/imt2.86biotherapyextracellular vesiclesmicrobiomemicrobiome–host interactionvaccine |
| spellingShingle | Rongjin Luo Yanmin Chang Huaizhen Liang Weifeng Zhang Yu Song Gaocai Li Cao Yang Interactions between extracellular vesicles and microbiome in human diseases: New therapeutic opportunities iMeta biotherapy extracellular vesicles microbiome microbiome–host interaction vaccine |
| title | Interactions between extracellular vesicles and microbiome in human diseases: New therapeutic opportunities |
| title_full | Interactions between extracellular vesicles and microbiome in human diseases: New therapeutic opportunities |
| title_fullStr | Interactions between extracellular vesicles and microbiome in human diseases: New therapeutic opportunities |
| title_full_unstemmed | Interactions between extracellular vesicles and microbiome in human diseases: New therapeutic opportunities |
| title_short | Interactions between extracellular vesicles and microbiome in human diseases: New therapeutic opportunities |
| title_sort | interactions between extracellular vesicles and microbiome in human diseases new therapeutic opportunities |
| topic | biotherapy extracellular vesicles microbiome microbiome–host interaction vaccine |
| url | https://doi.org/10.1002/imt2.86 |
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