Reduced CD4+T Cell CXCR3 Expression in Patients With Allergic Rhinitis
While T cells are considered to play a primary role in IgE-mediated atopic diseases, little is known about the systemic variations of T cell subsets from patients with allergic rhinitis (AR). To elucidate the characteristics of peripheral T cells, we analyzed natural killer, B cell, and T cell popul...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.581180/full |
| _version_ | 1818115118472364032 |
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| author | Xiaofeng Yu Meng Wang Zhiwei Cao |
| author_facet | Xiaofeng Yu Meng Wang Zhiwei Cao |
| author_sort | Xiaofeng Yu |
| collection | DOAJ |
| description | While T cells are considered to play a primary role in IgE-mediated atopic diseases, little is known about the systemic variations of T cell subsets from patients with allergic rhinitis (AR). To elucidate the characteristics of peripheral T cells, we analyzed natural killer, B cell, and T cell populations, performed T cell subset construction, and assessed chemokine receptor and associated serum cytokine expression in 25 AR patients and 20 healthy controls. Our results revealed increased levels of CD4+T cells, serum interleukin (IL)-10, IL-6, and interferon (IFN)-γ, and reduced Th1 and Th17 subsets, identified by their chemokine receptors, in AR patients. These results suggest a systemic activation of T cell responses in AR. We further demonstrated that AR patients exhibit significantly reduced CD4+T cell CXCR3 expression, especially in patients with moderate-severe disease severity, demonstrating that CXCR3 is a potential key molecule that hinders the Th1/Th2 balance in AR pathology. Overall, systemic T cell activation occurred in AR patients and CXCR3 dramatically decreased in CD4+T cells, which may ultimately be used as a potential disease and/or therapeutic target. |
| first_indexed | 2024-12-11T04:01:32Z |
| format | Article |
| id | doaj.art-45b3d026e4334d8ea253ffe48e55d036 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T04:01:32Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-45b3d026e4334d8ea253ffe48e55d0362022-12-22T01:21:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-11-011110.3389/fimmu.2020.581180581180Reduced CD4+T Cell CXCR3 Expression in Patients With Allergic RhinitisXiaofeng YuMeng WangZhiwei CaoWhile T cells are considered to play a primary role in IgE-mediated atopic diseases, little is known about the systemic variations of T cell subsets from patients with allergic rhinitis (AR). To elucidate the characteristics of peripheral T cells, we analyzed natural killer, B cell, and T cell populations, performed T cell subset construction, and assessed chemokine receptor and associated serum cytokine expression in 25 AR patients and 20 healthy controls. Our results revealed increased levels of CD4+T cells, serum interleukin (IL)-10, IL-6, and interferon (IFN)-γ, and reduced Th1 and Th17 subsets, identified by their chemokine receptors, in AR patients. These results suggest a systemic activation of T cell responses in AR. We further demonstrated that AR patients exhibit significantly reduced CD4+T cell CXCR3 expression, especially in patients with moderate-severe disease severity, demonstrating that CXCR3 is a potential key molecule that hinders the Th1/Th2 balance in AR pathology. Overall, systemic T cell activation occurred in AR patients and CXCR3 dramatically decreased in CD4+T cells, which may ultimately be used as a potential disease and/or therapeutic target.https://www.frontiersin.org/articles/10.3389/fimmu.2020.581180/fullCD4+ T CellCXCR3allergic rhinitisT cell subsetcytokines |
| spellingShingle | Xiaofeng Yu Meng Wang Zhiwei Cao Reduced CD4+T Cell CXCR3 Expression in Patients With Allergic Rhinitis Frontiers in Immunology CD4+ T Cell CXCR3 allergic rhinitis T cell subset cytokines |
| title | Reduced CD4+T Cell CXCR3 Expression in Patients With Allergic Rhinitis |
| title_full | Reduced CD4+T Cell CXCR3 Expression in Patients With Allergic Rhinitis |
| title_fullStr | Reduced CD4+T Cell CXCR3 Expression in Patients With Allergic Rhinitis |
| title_full_unstemmed | Reduced CD4+T Cell CXCR3 Expression in Patients With Allergic Rhinitis |
| title_short | Reduced CD4+T Cell CXCR3 Expression in Patients With Allergic Rhinitis |
| title_sort | reduced cd4 t cell cxcr3 expression in patients with allergic rhinitis |
| topic | CD4+ T Cell CXCR3 allergic rhinitis T cell subset cytokines |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2020.581180/full |
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