Tapentadol, a novel analgesic: Review of recent trends in synthesis, related substances, analytical methods, pharmacodynamics and pharmacokinetics
This write-up describes the comprehensive facts of tapentadol, on recent trends in synthesis, related substances, analytical methods, pharmacodynamics, pharmacokinetics, adverse effect and drug interaction. Chemically, tapentadol is 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl] phenol hydroch...
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| Format: | Article |
| Language: | English |
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Faculty of Pharmacy, Cairo University
2013-12-01
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| Series: | Bulletin of Faculty of Pharmacy Cairo University |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110093113000239 |
| _version_ | 1797970092504383488 |
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| author | Deepti Jain Pawan Kumar Basniwal |
| author_facet | Deepti Jain Pawan Kumar Basniwal |
| author_sort | Deepti Jain |
| collection | DOAJ |
| description | This write-up describes the comprehensive facts of tapentadol, on recent trends in synthesis, related substances, analytical methods, pharmacodynamics, pharmacokinetics, adverse effect and drug interaction. Chemically, tapentadol is 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl] phenol hydrochloride. Tapentadol is a centrally-acting synthetic novel analgesic which acts as μ-opioid receptor agonist as well as norepinephrine re-uptake inhibitor. Nausea and vomiting are common side effects and tapentadol glucuronide conjugate is a major metabolite excreted in urine. It is synthesized by three different schemes while nine related substances were reported. Tapentadol and its metabolites were determined in plasma matrix by chromatographic methods using spectrofluorometric detection. |
| first_indexed | 2024-04-11T03:12:34Z |
| format | Article |
| id | doaj.art-45b40b6f98204639b7082ef8c6defe78 |
| institution | Directory Open Access Journal |
| issn | 1110-0931 |
| language | English |
| last_indexed | 2024-04-11T03:12:34Z |
| publishDate | 2013-12-01 |
| publisher | Faculty of Pharmacy, Cairo University |
| record_format | Article |
| series | Bulletin of Faculty of Pharmacy Cairo University |
| spelling | doaj.art-45b40b6f98204639b7082ef8c6defe782023-01-02T11:18:20ZengFaculty of Pharmacy, Cairo UniversityBulletin of Faculty of Pharmacy Cairo University1110-09312013-12-0151228328910.1016/j.bfopcu.2013.04.003Tapentadol, a novel analgesic: Review of recent trends in synthesis, related substances, analytical methods, pharmacodynamics and pharmacokineticsDeepti Jain0Pawan Kumar Basniwal1School of Pharmaceutical Sciences, Rajiv Gandhi Technological University, Bhopal 462 033, Madhya Pradesh, IndiaSchool of Pharmaceutical Sciences, Rajiv Gandhi Technological University, Bhopal 462 033, Madhya Pradesh, IndiaThis write-up describes the comprehensive facts of tapentadol, on recent trends in synthesis, related substances, analytical methods, pharmacodynamics, pharmacokinetics, adverse effect and drug interaction. Chemically, tapentadol is 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl] phenol hydrochloride. Tapentadol is a centrally-acting synthetic novel analgesic which acts as μ-opioid receptor agonist as well as norepinephrine re-uptake inhibitor. Nausea and vomiting are common side effects and tapentadol glucuronide conjugate is a major metabolite excreted in urine. It is synthesized by three different schemes while nine related substances were reported. Tapentadol and its metabolites were determined in plasma matrix by chromatographic methods using spectrofluorometric detection.http://www.sciencedirect.com/science/article/pii/S1110093113000239AnalysisChemistryPharmacodynamicsPharmacokineticsTapentadol |
| spellingShingle | Deepti Jain Pawan Kumar Basniwal Tapentadol, a novel analgesic: Review of recent trends in synthesis, related substances, analytical methods, pharmacodynamics and pharmacokinetics Bulletin of Faculty of Pharmacy Cairo University Analysis Chemistry Pharmacodynamics Pharmacokinetics Tapentadol |
| title | Tapentadol, a novel analgesic: Review of recent trends in synthesis, related substances, analytical methods, pharmacodynamics and pharmacokinetics |
| title_full | Tapentadol, a novel analgesic: Review of recent trends in synthesis, related substances, analytical methods, pharmacodynamics and pharmacokinetics |
| title_fullStr | Tapentadol, a novel analgesic: Review of recent trends in synthesis, related substances, analytical methods, pharmacodynamics and pharmacokinetics |
| title_full_unstemmed | Tapentadol, a novel analgesic: Review of recent trends in synthesis, related substances, analytical methods, pharmacodynamics and pharmacokinetics |
| title_short | Tapentadol, a novel analgesic: Review of recent trends in synthesis, related substances, analytical methods, pharmacodynamics and pharmacokinetics |
| title_sort | tapentadol a novel analgesic review of recent trends in synthesis related substances analytical methods pharmacodynamics and pharmacokinetics |
| topic | Analysis Chemistry Pharmacodynamics Pharmacokinetics Tapentadol |
| url | http://www.sciencedirect.com/science/article/pii/S1110093113000239 |
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