Advances in nanotechnology for the treatment of GBM
Glioblastoma (GBM), a highly malignant glioma of the central nervous system, is the most dread and common brain tumor with a high rate of therapeutic resistance and recurrence. Currently, the clinical treatment methods are surgery, radiotherapy, and chemotherapy. However, owning to the highly invasi...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1180943/full |
| _version_ | 1797833105384407040 |
|---|---|
| author | Dongyan Wei Dongyan Wei Ni Zhang Shuang Qu Hao Wang Jin Li |
| author_facet | Dongyan Wei Dongyan Wei Ni Zhang Shuang Qu Hao Wang Jin Li |
| author_sort | Dongyan Wei |
| collection | DOAJ |
| description | Glioblastoma (GBM), a highly malignant glioma of the central nervous system, is the most dread and common brain tumor with a high rate of therapeutic resistance and recurrence. Currently, the clinical treatment methods are surgery, radiotherapy, and chemotherapy. However, owning to the highly invasive nature of GBM, it is difficult to completely resect them due to the unclear boundary between the edges of GBM and normal brain tissue. Traditional radiotherapy and the combination of alkylating agents and radiotherapy have significant side effects, therapeutic drugs are difficult to penetrate the blood brain barrier. Patients receiving treatment have a high postoperative recurrence rate and a median survival of less than 2 years, Less than 5% of patients live longer than 5 years. Therefore, it is urgent to achieve precise treatment through the blood brain barrier and reduce toxic and side effects. Nanotechnology exhibit great potential in this area. This article summarizes the current treatment methods and shortcomings of GBM, and summarizes the research progress in the diagnosis and treatment of GBM using nanotechnology. |
| first_indexed | 2024-04-09T14:18:21Z |
| format | Article |
| id | doaj.art-45b59de9112c4746937ff74b49e48242 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-09T14:18:21Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-45b59de9112c4746937ff74b49e482422023-05-05T04:53:22ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-05-011710.3389/fnins.2023.11809431180943Advances in nanotechnology for the treatment of GBMDongyan Wei0Dongyan Wei1Ni Zhang2Shuang Qu3Hao Wang4Jin Li5Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, ChinaCollege of Life Sciences, Tarim University, Alar, ChinaMental Health Center, West China Hospital, Sichuan University, Chengdu, ChinaCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing, ChinaCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing, ChinaDepartment of Psychiatry, West China Hospital, Sichuan University, Chengdu, ChinaGlioblastoma (GBM), a highly malignant glioma of the central nervous system, is the most dread and common brain tumor with a high rate of therapeutic resistance and recurrence. Currently, the clinical treatment methods are surgery, radiotherapy, and chemotherapy. However, owning to the highly invasive nature of GBM, it is difficult to completely resect them due to the unclear boundary between the edges of GBM and normal brain tissue. Traditional radiotherapy and the combination of alkylating agents and radiotherapy have significant side effects, therapeutic drugs are difficult to penetrate the blood brain barrier. Patients receiving treatment have a high postoperative recurrence rate and a median survival of less than 2 years, Less than 5% of patients live longer than 5 years. Therefore, it is urgent to achieve precise treatment through the blood brain barrier and reduce toxic and side effects. Nanotechnology exhibit great potential in this area. This article summarizes the current treatment methods and shortcomings of GBM, and summarizes the research progress in the diagnosis and treatment of GBM using nanotechnology.https://www.frontiersin.org/articles/10.3389/fnins.2023.1180943/fullmalignant gliomananotechnologytumor diagnosistumor therapytargeted therapy |
| spellingShingle | Dongyan Wei Dongyan Wei Ni Zhang Shuang Qu Hao Wang Jin Li Advances in nanotechnology for the treatment of GBM Frontiers in Neuroscience malignant glioma nanotechnology tumor diagnosis tumor therapy targeted therapy |
| title | Advances in nanotechnology for the treatment of GBM |
| title_full | Advances in nanotechnology for the treatment of GBM |
| title_fullStr | Advances in nanotechnology for the treatment of GBM |
| title_full_unstemmed | Advances in nanotechnology for the treatment of GBM |
| title_short | Advances in nanotechnology for the treatment of GBM |
| title_sort | advances in nanotechnology for the treatment of gbm |
| topic | malignant glioma nanotechnology tumor diagnosis tumor therapy targeted therapy |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1180943/full |
| work_keys_str_mv | AT dongyanwei advancesinnanotechnologyforthetreatmentofgbm AT dongyanwei advancesinnanotechnologyforthetreatmentofgbm AT nizhang advancesinnanotechnologyforthetreatmentofgbm AT shuangqu advancesinnanotechnologyforthetreatmentofgbm AT haowang advancesinnanotechnologyforthetreatmentofgbm AT jinli advancesinnanotechnologyforthetreatmentofgbm |