<i>Rhaponticum uniflorum</i> and <i>Serratula centauroides</i> Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress
In modern life, the use of plant stress-protectors has taken on particular significance due to the wide distribution of neurosis-like and neurotic diseases caused by neuroendocrine-immune system imbalance. Special attention has been paid to the plants containing ecdysteroids, i.e., hormone-like bioa...
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MDPI AG
2021-11-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/11/1186 |
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| author | Larisa N. Shantanova Daniil N. Olennikov Irinchey E. Matkhanov Sergey M. Gulyaev Anyuta A. Toropova Irina G. Nikolaeva Sergey M. Nikolaev |
| author_facet | Larisa N. Shantanova Daniil N. Olennikov Irinchey E. Matkhanov Sergey M. Gulyaev Anyuta A. Toropova Irina G. Nikolaeva Sergey M. Nikolaev |
| author_sort | Larisa N. Shantanova |
| collection | DOAJ |
| description | In modern life, the use of plant stress-protectors has taken on particular significance due to the wide distribution of neurosis-like and neurotic diseases caused by neuroendocrine-immune system imbalance. Special attention has been paid to the plants containing ecdysteroids, i.e., hormone-like bioactive substances with high adaptogenic activity. The article deals with the study of bioactivity of two plant extracts as <i>Rhaponticum uniflorum</i> (L.) DC. and <i>Serratula centauroides</i> L. with a high content of ecdysteroids and phenolic compounds. The models of acute and chronic emotional stress in white rats were used to estimate the stress-protective activity of <i>R. uniflorum</i> and <i>S. centauroides</i> extracts. Both extracts showed the stress-protective effect via inhibiting the development of signs induced by single and long-term effects of stress factors. In acute stress, the development of Selye's triad signs was less pronounced against the background of the plant remedies introduction. In chronic stress, the extracts prevented the development of anxiety-depressive syndrome. Besides, <i>R. uniflorum</i> and <i>S. centauroides</i> extracts banned the development of stress-induced injuries in the brain cortex and had a neuroprotective effect on ischemia against chronic stress. The stress-protective effects of both plant extracts were based on a decrease of hyperactivation of the central stress-promoting systems (sympathoadrenal, hypothalamic-pituitary-adrenal) due to their GABA-mimetic effects. Peripheral mechanisms were connected with the inhibition of free radical oxidation processes and with an increase in the endogenous antioxidant system activity. Thus, <i>R. uniflorum</i> and <i>S. centauroides</i> extracts have a high potential to increase non-specific body resistance against acute and chronic emotional stress effects. |
| first_indexed | 2024-03-10T05:09:49Z |
| format | Article |
| id | doaj.art-45b5ea7220774a3e8069265c5340ed33 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T05:09:49Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-45b5ea7220774a3e8069265c5340ed332023-11-23T00:56:34ZengMDPI AGPharmaceuticals1424-82472021-11-011411118610.3390/ph14111186<i>Rhaponticum uniflorum</i> and <i>Serratula centauroides</i> Extracts Attenuate Emotional Injury in Acute and Chronic Emotional StressLarisa N. Shantanova0Daniil N. Olennikov1Irinchey E. Matkhanov2Sergey M. Gulyaev3Anyuta A. Toropova4Irina G. Nikolaeva5Sergey M. Nikolaev6Institute of General and Experimental Biology, Siberian Branch of Russian Academy of Science, Sakhyanovoy Str. 6, 670047 Ulan-Ude, RussiaInstitute of General and Experimental Biology, Siberian Branch of Russian Academy of Science, Sakhyanovoy Str. 6, 670047 Ulan-Ude, RussiaInstitute of Medicine, Buryat State University, Oktyabrskaya Str.36a, 670002 Ulan-Ude, RussiaInstitute of General and Experimental Biology, Siberian Branch of Russian Academy of Science, Sakhyanovoy Str. 6, 670047 Ulan-Ude, RussiaInstitute of General and Experimental Biology, Siberian Branch of Russian Academy of Science, Sakhyanovoy Str. 6, 670047 Ulan-Ude, RussiaInstitute of General and Experimental Biology, Siberian Branch of Russian Academy of Science, Sakhyanovoy Str. 6, 670047 Ulan-Ude, RussiaInstitute of General and Experimental Biology, Siberian Branch of Russian Academy of Science, Sakhyanovoy Str. 6, 670047 Ulan-Ude, RussiaIn modern life, the use of plant stress-protectors has taken on particular significance due to the wide distribution of neurosis-like and neurotic diseases caused by neuroendocrine-immune system imbalance. Special attention has been paid to the plants containing ecdysteroids, i.e., hormone-like bioactive substances with high adaptogenic activity. The article deals with the study of bioactivity of two plant extracts as <i>Rhaponticum uniflorum</i> (L.) DC. and <i>Serratula centauroides</i> L. with a high content of ecdysteroids and phenolic compounds. The models of acute and chronic emotional stress in white rats were used to estimate the stress-protective activity of <i>R. uniflorum</i> and <i>S. centauroides</i> extracts. Both extracts showed the stress-protective effect via inhibiting the development of signs induced by single and long-term effects of stress factors. In acute stress, the development of Selye's triad signs was less pronounced against the background of the plant remedies introduction. In chronic stress, the extracts prevented the development of anxiety-depressive syndrome. Besides, <i>R. uniflorum</i> and <i>S. centauroides</i> extracts banned the development of stress-induced injuries in the brain cortex and had a neuroprotective effect on ischemia against chronic stress. The stress-protective effects of both plant extracts were based on a decrease of hyperactivation of the central stress-promoting systems (sympathoadrenal, hypothalamic-pituitary-adrenal) due to their GABA-mimetic effects. Peripheral mechanisms were connected with the inhibition of free radical oxidation processes and with an increase in the endogenous antioxidant system activity. Thus, <i>R. uniflorum</i> and <i>S. centauroides</i> extracts have a high potential to increase non-specific body resistance against acute and chronic emotional stress effects.https://www.mdpi.com/1424-8247/14/11/1186<i>Rhaponticum uniflorum</i><i>Serratula centauroides</i>ecdysteroidscaffeoylquinic acidsemotional stressdepression |
| spellingShingle | Larisa N. Shantanova Daniil N. Olennikov Irinchey E. Matkhanov Sergey M. Gulyaev Anyuta A. Toropova Irina G. Nikolaeva Sergey M. Nikolaev <i>Rhaponticum uniflorum</i> and <i>Serratula centauroides</i> Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress Pharmaceuticals <i>Rhaponticum uniflorum</i> <i>Serratula centauroides</i> ecdysteroids caffeoylquinic acids emotional stress depression |
| title | <i>Rhaponticum uniflorum</i> and <i>Serratula centauroides</i> Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress |
| title_full | <i>Rhaponticum uniflorum</i> and <i>Serratula centauroides</i> Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress |
| title_fullStr | <i>Rhaponticum uniflorum</i> and <i>Serratula centauroides</i> Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress |
| title_full_unstemmed | <i>Rhaponticum uniflorum</i> and <i>Serratula centauroides</i> Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress |
| title_short | <i>Rhaponticum uniflorum</i> and <i>Serratula centauroides</i> Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress |
| title_sort | i rhaponticum uniflorum i and i serratula centauroides i extracts attenuate emotional injury in acute and chronic emotional stress |
| topic | <i>Rhaponticum uniflorum</i> <i>Serratula centauroides</i> ecdysteroids caffeoylquinic acids emotional stress depression |
| url | https://www.mdpi.com/1424-8247/14/11/1186 |
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