Relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with Babesia canis canis
Abstract Background Canine babesiosis is caused by species of the Babesia genus and has become an emerging disease worldwide. To the authors’ knowledge there are no reports in which antioxidants have been analyzed in different presentations of canine babesiosis or in which the prognostic value of an...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-04-01
|
| Series: | BMC Veterinary Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12917-017-1020-9 |
| _version_ | 1811318555102150656 |
|---|---|
| author | Martina Crnogaj José Joaquin Cerón Iva Šmit Ivana Kiš Jelena Gotić Mirna Brkljačić Vesna Matijatko Camila Peres Rubio Nada Kučer Vladimir Mrljak |
| author_facet | Martina Crnogaj José Joaquin Cerón Iva Šmit Ivana Kiš Jelena Gotić Mirna Brkljačić Vesna Matijatko Camila Peres Rubio Nada Kučer Vladimir Mrljak |
| author_sort | Martina Crnogaj |
| collection | DOAJ |
| description | Abstract Background Canine babesiosis is caused by species of the Babesia genus and has become an emerging disease worldwide. To the authors’ knowledge there are no reports in which antioxidants have been analyzed in different presentations of canine babesiosis or in which the prognostic value of antioxidants has been studied. The aim of this study was to evaluate whether oxidative stress could be related to the severity and outcome of canine babesiosis. For this purpose a profile consisting of four antioxidant biomarkers (superoxide dismutase - SOD, glutathione peroxidase - GPx, catalase, total antioxidant status - TAS) and malondialdehyde - MDA as an oxidant biomarker (previously evaluated, here studied for comparative purposes) were evaluated in dogs with canine babesiosis of different clinical severity and outcomes. Results The study was conducted with a sample of 40 dogs suffering from babesiosis (further divided into uncomplicated, one complication and multiple organ dysfunction syndrome - MODS group) and 30 healthy dogs (control group). Additionally, the babesiosis group was divided according to the anaemia into non-anaemic, mildly anaemic, moderately anaemic and severely anaemic dogs. The results of our study showed significantly decreased SOD, catalase and TAS values in diseased dogs compared to controls, while there were no significant differences in GPx between these groups. Dogs that developed MODS showed lower activities of SOD and GPx and higher MDA values compared to dogs with uncomplicated babesiosis as well as with dogs that developed one complication. Superoxide dismutase, catalase and GPx were negatively correlated whereas MDA was positively correlated with the lethal outcome of the disease. Furthermore, this study detected more pronounced decrease in antioxidant biomarkers (SOD, GPx and catalase) in dogs with moderate anaemia compared to those with mild anaemia. Conclusions The results of this study showed changes in biomarkers related to the antioxidant status of dogs naturally infected with B. canis canis. These biomarkers could be used as indicators of disease severity and outcome in dogs suffering from babesiosis. |
| first_indexed | 2024-04-13T12:27:52Z |
| format | Article |
| id | doaj.art-45b63e08ea67470d9f658222b21ecf28 |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-04-13T12:27:52Z |
| publishDate | 2017-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-45b63e08ea67470d9f658222b21ecf282022-12-22T02:46:58ZengBMCBMC Veterinary Research1746-61482017-04-011311910.1186/s12917-017-1020-9Relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with Babesia canis canisMartina Crnogaj0José Joaquin Cerón1Iva Šmit2Ivana Kiš3Jelena Gotić4Mirna Brkljačić5Vesna Matijatko6Camila Peres Rubio7Nada Kučer8Vladimir Mrljak9Clinic for Internal Diseases, Faculty of Veterinary Medicine, University of ZagrebDepartment of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of MurciaClinic for Internal Diseases, Faculty of Veterinary Medicine, University of ZagrebClinic for Internal Diseases, Faculty of Veterinary Medicine, University of ZagrebClinic for Internal Diseases, Faculty of Veterinary Medicine, University of ZagrebClinic for Internal Diseases, Faculty of Veterinary Medicine, University of ZagrebClinic for Internal Diseases, Faculty of Veterinary Medicine, University of ZagrebDepartment of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of MurciaClinic for Internal Diseases, Faculty of Veterinary Medicine, University of ZagrebClinic for Internal Diseases, Faculty of Veterinary Medicine, University of ZagrebAbstract Background Canine babesiosis is caused by species of the Babesia genus and has become an emerging disease worldwide. To the authors’ knowledge there are no reports in which antioxidants have been analyzed in different presentations of canine babesiosis or in which the prognostic value of antioxidants has been studied. The aim of this study was to evaluate whether oxidative stress could be related to the severity and outcome of canine babesiosis. For this purpose a profile consisting of four antioxidant biomarkers (superoxide dismutase - SOD, glutathione peroxidase - GPx, catalase, total antioxidant status - TAS) and malondialdehyde - MDA as an oxidant biomarker (previously evaluated, here studied for comparative purposes) were evaluated in dogs with canine babesiosis of different clinical severity and outcomes. Results The study was conducted with a sample of 40 dogs suffering from babesiosis (further divided into uncomplicated, one complication and multiple organ dysfunction syndrome - MODS group) and 30 healthy dogs (control group). Additionally, the babesiosis group was divided according to the anaemia into non-anaemic, mildly anaemic, moderately anaemic and severely anaemic dogs. The results of our study showed significantly decreased SOD, catalase and TAS values in diseased dogs compared to controls, while there were no significant differences in GPx between these groups. Dogs that developed MODS showed lower activities of SOD and GPx and higher MDA values compared to dogs with uncomplicated babesiosis as well as with dogs that developed one complication. Superoxide dismutase, catalase and GPx were negatively correlated whereas MDA was positively correlated with the lethal outcome of the disease. Furthermore, this study detected more pronounced decrease in antioxidant biomarkers (SOD, GPx and catalase) in dogs with moderate anaemia compared to those with mild anaemia. Conclusions The results of this study showed changes in biomarkers related to the antioxidant status of dogs naturally infected with B. canis canis. These biomarkers could be used as indicators of disease severity and outcome in dogs suffering from babesiosis.http://link.springer.com/article/10.1186/s12917-017-1020-9BabesiosisDogAntioxidant statusGlutathione peroxidase (GPx)Superoxide dismutase (SOD)Catalase |
| spellingShingle | Martina Crnogaj José Joaquin Cerón Iva Šmit Ivana Kiš Jelena Gotić Mirna Brkljačić Vesna Matijatko Camila Peres Rubio Nada Kučer Vladimir Mrljak Relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with Babesia canis canis BMC Veterinary Research Babesiosis Dog Antioxidant status Glutathione peroxidase (GPx) Superoxide dismutase (SOD) Catalase |
| title | Relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with Babesia canis canis |
| title_full | Relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with Babesia canis canis |
| title_fullStr | Relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with Babesia canis canis |
| title_full_unstemmed | Relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with Babesia canis canis |
| title_short | Relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with Babesia canis canis |
| title_sort | relation of antioxidant status at admission and disease severity and outcome in dogs naturally infected with babesia canis canis |
| topic | Babesiosis Dog Antioxidant status Glutathione peroxidase (GPx) Superoxide dismutase (SOD) Catalase |
| url | http://link.springer.com/article/10.1186/s12917-017-1020-9 |
| work_keys_str_mv | AT martinacrnogaj relationofantioxidantstatusatadmissionanddiseaseseverityandoutcomeindogsnaturallyinfectedwithbabesiacaniscanis AT josejoaquinceron relationofantioxidantstatusatadmissionanddiseaseseverityandoutcomeindogsnaturallyinfectedwithbabesiacaniscanis AT ivasmit relationofantioxidantstatusatadmissionanddiseaseseverityandoutcomeindogsnaturallyinfectedwithbabesiacaniscanis AT ivanakis relationofantioxidantstatusatadmissionanddiseaseseverityandoutcomeindogsnaturallyinfectedwithbabesiacaniscanis AT jelenagotic relationofantioxidantstatusatadmissionanddiseaseseverityandoutcomeindogsnaturallyinfectedwithbabesiacaniscanis AT mirnabrkljacic relationofantioxidantstatusatadmissionanddiseaseseverityandoutcomeindogsnaturallyinfectedwithbabesiacaniscanis AT vesnamatijatko relationofantioxidantstatusatadmissionanddiseaseseverityandoutcomeindogsnaturallyinfectedwithbabesiacaniscanis AT camilaperesrubio relationofantioxidantstatusatadmissionanddiseaseseverityandoutcomeindogsnaturallyinfectedwithbabesiacaniscanis AT nadakucer relationofantioxidantstatusatadmissionanddiseaseseverityandoutcomeindogsnaturallyinfectedwithbabesiacaniscanis AT vladimirmrljak relationofantioxidantstatusatadmissionanddiseaseseverityandoutcomeindogsnaturallyinfectedwithbabesiacaniscanis |