Natural coagulation inhibitors and active protein c resistance in preeclampsia
INTRODUCTION: The etiology of preeclampsia is not fully established. A few studies have shown a relationship between natural coagulation inhibitors and preeclampsia. OBJECTIVES: The purpose of this study was to investigate the status of natural coagulation inhibitors and active protein C resistance...
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| Format: | Article |
| Language: | English |
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Elsevier España
2010-01-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010001100011 |
| _version_ | 1818112917592080384 |
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| author | Cengiz Demir Imdat Dilek |
| author_facet | Cengiz Demir Imdat Dilek |
| author_sort | Cengiz Demir |
| collection | DOAJ |
| description | INTRODUCTION: The etiology of preeclampsia is not fully established. A few studies have shown a relationship between natural coagulation inhibitors and preeclampsia. OBJECTIVES: The purpose of this study was to investigate the status of natural coagulation inhibitors and active protein C resistance (APC-R) in preeclampsia. PATIENTS AND METHODS: We studied 70 women with preeclampsia recruited consecutively and 70 healthy pregnant and 70 nonpregnant women as controls. Plasma protein C (PC), free protein S (fPS), antithrombin III (ATIII) and APC-R were evaluated. RESULTS: ATIII values were found to be significantly lower in preeclamptic patients than in the control groups (p< 0.001). Nevertheless, there was no significant difference between the healthy pregnant and nonpregnant women groups (p=0.141). The fPS values of the preeclamptic and healthy pregnant groups were lower than that of the nonpregnant group (p< 0.001), and the fPS value of the preeclamptic pregnant women was lower than that of healthy pregnant women (p<0.001). The PC value of the preeclamptic pregnant women was lower than that of the control groups (p< 0.001). The PC value of the healthy pregnant women was lower than that of the nonpregnant women (p< 0.001). The mean APC activity values were lower in the preeclamptic patients than that of the control groups (p< 0.001, p< 0.001). The APC-R positivity rates of the preeclamptic groups were higher than that of the control groups (p<0.001). CONCLUSIONS: This study demonstrated that ATIII, fPS, PC values and APC resistance were lower and APC-R positivity was higher in preeclamptic women than in normal pregnant and nonpregnant women. |
| first_indexed | 2024-12-11T03:26:33Z |
| format | Article |
| id | doaj.art-45b6701dedf141c3a5d4ba02c1fa2a83 |
| institution | Directory Open Access Journal |
| issn | 1807-5932 1980-5322 |
| language | English |
| last_indexed | 2024-12-11T03:26:33Z |
| publishDate | 2010-01-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-45b6701dedf141c3a5d4ba02c1fa2a832022-12-22T01:22:30ZengElsevier EspañaClinics1807-59321980-53222010-01-0165111119112210.1590/S1807-59322010001100011Natural coagulation inhibitors and active protein c resistance in preeclampsiaCengiz DemirImdat DilekINTRODUCTION: The etiology of preeclampsia is not fully established. A few studies have shown a relationship between natural coagulation inhibitors and preeclampsia. OBJECTIVES: The purpose of this study was to investigate the status of natural coagulation inhibitors and active protein C resistance (APC-R) in preeclampsia. PATIENTS AND METHODS: We studied 70 women with preeclampsia recruited consecutively and 70 healthy pregnant and 70 nonpregnant women as controls. Plasma protein C (PC), free protein S (fPS), antithrombin III (ATIII) and APC-R were evaluated. RESULTS: ATIII values were found to be significantly lower in preeclamptic patients than in the control groups (p< 0.001). Nevertheless, there was no significant difference between the healthy pregnant and nonpregnant women groups (p=0.141). The fPS values of the preeclamptic and healthy pregnant groups were lower than that of the nonpregnant group (p< 0.001), and the fPS value of the preeclamptic pregnant women was lower than that of healthy pregnant women (p<0.001). The PC value of the preeclamptic pregnant women was lower than that of the control groups (p< 0.001). The PC value of the healthy pregnant women was lower than that of the nonpregnant women (p< 0.001). The mean APC activity values were lower in the preeclamptic patients than that of the control groups (p< 0.001, p< 0.001). The APC-R positivity rates of the preeclamptic groups were higher than that of the control groups (p<0.001). CONCLUSIONS: This study demonstrated that ATIII, fPS, PC values and APC resistance were lower and APC-R positivity was higher in preeclamptic women than in normal pregnant and nonpregnant women.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010001100011Natural Coagulation InhibitorsAPC-RRiskPathogenesisPreeclampsia |
| spellingShingle | Cengiz Demir Imdat Dilek Natural coagulation inhibitors and active protein c resistance in preeclampsia Clinics Natural Coagulation Inhibitors APC-R Risk Pathogenesis Preeclampsia |
| title | Natural coagulation inhibitors and active protein c resistance in preeclampsia |
| title_full | Natural coagulation inhibitors and active protein c resistance in preeclampsia |
| title_fullStr | Natural coagulation inhibitors and active protein c resistance in preeclampsia |
| title_full_unstemmed | Natural coagulation inhibitors and active protein c resistance in preeclampsia |
| title_short | Natural coagulation inhibitors and active protein c resistance in preeclampsia |
| title_sort | natural coagulation inhibitors and active protein c resistance in preeclampsia |
| topic | Natural Coagulation Inhibitors APC-R Risk Pathogenesis Preeclampsia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010001100011 |
| work_keys_str_mv | AT cengizdemir naturalcoagulationinhibitorsandactiveproteincresistanceinpreeclampsia AT imdatdilek naturalcoagulationinhibitorsandactiveproteincresistanceinpreeclampsia |