Comparison of visual assessment and computer image analysis of intracoronary thrombus type by optical coherence tomography.
BACKGROUND:Analysis of intracoronary thrombus type by optical coherence tomography (OCT) imaging is highly subjective. We aimed to compare a newly developed image analysis method to subjective visual classification of thrombus type identified by OCT. METHODS:Thirty patients with acute ST elevation m...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0209110 |
| _version_ | 1819016590833745920 |
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| author | Timo P Kaivosoja Shengnan Liu Jouke Dijkstra Heini Huhtala Tej Sheth Olli A Kajander |
| author_facet | Timo P Kaivosoja Shengnan Liu Jouke Dijkstra Heini Huhtala Tej Sheth Olli A Kajander |
| author_sort | Timo P Kaivosoja |
| collection | DOAJ |
| description | BACKGROUND:Analysis of intracoronary thrombus type by optical coherence tomography (OCT) imaging is highly subjective. We aimed to compare a newly developed image analysis method to subjective visual classification of thrombus type identified by OCT. METHODS:Thirty patients with acute ST elevation myocardial infarction were included. Thrombus type visually classified by two independent readers was compared with analysis using QCU-CMS software. RESULTS:Repeatability of the computer-based measurements was good. By using a ROC, area under curve values for discrimination of white and red thrombi were 0.92 (95% confidence intervals (CI) 0.83-1.00) for median attenuation, 0.96 (95% CI 0.89-1.00) for mean backscatter and 0.96 (95% CI 0.89-1.00) for mean grayscale intensity. Median attenuation of 0.57 mm-1 (sensitivity 100%, specificity 71%), mean backscatter of 5.35 (sensitivity 92%, specificity 94%) and mean grayscale intensity of 120.1 (sensitivity 85%, specificity 100%) were identified as the best cut-off values to differentiate between red and white thrombi. CONCLUSIONS:Attenuation, backscatter and grayscale intensity of thrombi in OCT images differentiated red and white thrombi with high sensitivity and specificity. Measurement of these continuous parameters can be used as a less user-dependent method to characterize in vivo thrombi. The clinical significance of these findings needs to be tested in further studies. |
| first_indexed | 2024-12-21T02:50:03Z |
| format | Article |
| id | doaj.art-45b73619e80e4db0afe2a15c1090dbc5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T02:50:03Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-45b73619e80e4db0afe2a15c1090dbc52022-12-21T19:18:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011312e020911010.1371/journal.pone.0209110Comparison of visual assessment and computer image analysis of intracoronary thrombus type by optical coherence tomography.Timo P KaivosojaShengnan LiuJouke DijkstraHeini HuhtalaTej ShethOlli A KajanderBACKGROUND:Analysis of intracoronary thrombus type by optical coherence tomography (OCT) imaging is highly subjective. We aimed to compare a newly developed image analysis method to subjective visual classification of thrombus type identified by OCT. METHODS:Thirty patients with acute ST elevation myocardial infarction were included. Thrombus type visually classified by two independent readers was compared with analysis using QCU-CMS software. RESULTS:Repeatability of the computer-based measurements was good. By using a ROC, area under curve values for discrimination of white and red thrombi were 0.92 (95% confidence intervals (CI) 0.83-1.00) for median attenuation, 0.96 (95% CI 0.89-1.00) for mean backscatter and 0.96 (95% CI 0.89-1.00) for mean grayscale intensity. Median attenuation of 0.57 mm-1 (sensitivity 100%, specificity 71%), mean backscatter of 5.35 (sensitivity 92%, specificity 94%) and mean grayscale intensity of 120.1 (sensitivity 85%, specificity 100%) were identified as the best cut-off values to differentiate between red and white thrombi. CONCLUSIONS:Attenuation, backscatter and grayscale intensity of thrombi in OCT images differentiated red and white thrombi with high sensitivity and specificity. Measurement of these continuous parameters can be used as a less user-dependent method to characterize in vivo thrombi. The clinical significance of these findings needs to be tested in further studies.https://doi.org/10.1371/journal.pone.0209110 |
| spellingShingle | Timo P Kaivosoja Shengnan Liu Jouke Dijkstra Heini Huhtala Tej Sheth Olli A Kajander Comparison of visual assessment and computer image analysis of intracoronary thrombus type by optical coherence tomography. PLoS ONE |
| title | Comparison of visual assessment and computer image analysis of intracoronary thrombus type by optical coherence tomography. |
| title_full | Comparison of visual assessment and computer image analysis of intracoronary thrombus type by optical coherence tomography. |
| title_fullStr | Comparison of visual assessment and computer image analysis of intracoronary thrombus type by optical coherence tomography. |
| title_full_unstemmed | Comparison of visual assessment and computer image analysis of intracoronary thrombus type by optical coherence tomography. |
| title_short | Comparison of visual assessment and computer image analysis of intracoronary thrombus type by optical coherence tomography. |
| title_sort | comparison of visual assessment and computer image analysis of intracoronary thrombus type by optical coherence tomography |
| url | https://doi.org/10.1371/journal.pone.0209110 |
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